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Oil-dispersed sodium hyaluronate and preparation method and application of same

A technology of sodium hyaluronate and oil dispersion, which is applied in body powder, pharmaceutical formulations, cosmetic preparations, etc., to achieve the effect of smooth skin feeling, not easy to gather and precipitate, and firmly lock water

Active Publication Date: 2015-04-15
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem that water-soluble sodium hyaluronate is difficult to add to the oil phase of cosmetics, the present invention provides a preparation technology of oil-dispersed sodium hyaluronate and its application in cosmetics application in

Method used

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  • Oil-dispersed sodium hyaluronate and preparation method and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (a) Take the HA ( M w =6,200 Da) micropowder 60.0g;

[0041] (b) Take 56.0g of castor bean oil, fully mix it with HA micropowder, homogenize it at 10000rpm for 3min, and preheat it to 90℃ in a water bath to get a suspension;

[0042] (c) Take 84.0g of hydrogenated castor oil, heat it to 90°C and melt it completely, stir and mix it with the preheated suspension in step (b) while it is still hot, and immediately homogenize at 10000rpm for 3 times, each time for 2min, with an interval of 20s . Finally, it is condensed and granulated to form milky white to light yellow solid particles.

[0043] The HA content determined by the carbazole method was 28.5%. The smear was observed under an electron microscope, and the HA micropowder in the oil phase presented irregular agglomerates, slightly swollen, and uniformly dispersed (see figure 1 ), the particle size analysis report shows that the final average particle size of the HA micropowder in the oil dispersion is 10.27 μm ...

Embodiment 2

[0045] (a) Take the HA ( M w = 3,000,000 Da) Micropowder 2.0g;

[0046] (b) Take 160.0g of castor oil, mix well with HA micropowder, homogenize at 500rpm for 3min, and preheat to 90°C in a water bath to obtain a suspension;

[0047] (c) Take 38.0g of hydrogenated castor oil, heat it to 90°C and melt it completely, stir and mix it with the preheated suspension in step (b) while it is hot, and immediately homogenize at 3000rpm for 3 times, each time for 3min, with an interval of 30s , forming milky white to light yellow ointment after cooling.

[0048] The HA content determined by the carbazole method was 1.0%. The particle size analysis report showed that the final average particle size of the HA micropowder in the oil dispersion was 15.73 μm. Placed at 40°C for 24 hours, the dispersion was stable without precipitation and stratification.

Embodiment 3

[0050] (a) Take 100.0g of HA micropowder through 80-mesh sieve (of which M w = 400 Da for HA and M w = 150,000 Da of HA each 50.0g), mix well;

[0051] (b) Fully mix HA micropowder with 10.0g ethylhexyl palmitate dispersant to fully infiltrate HA, then mix with 40.0g olive oil and 20.0g polydimethylsiloxane (500 mm 2 / s) mix evenly, and homogenize at 8000rpm for 2min to obtain a suspension;

[0052] (c) Add 30.0 g of polydimethylsiloxane cross-linked polymer to the suspension, homogenize at 10,000 rpm for 3 times, each time for 2 minutes, with an interval of 30 seconds, to form a milky white to light yellow viscous liquid, and cool to obtain .

[0053] The HA content determined by the carbazole method was 49.8%. The particle size analysis report showed that the final average particle size of the HA micropowder in the oil dispersion was 17.02 μm. Placed at 40°C for 24 hours, the dispersion was stable without precipitation and stratification.

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Abstract

The invention discloses an oil-dispersed sodium hyaluronate, a preparation method of the same, and an application of the oil-dispersed sodium hyaluronate to cosmetics. The oil-dispersed sodium hyaluronate comprises, by mass percentage, 1%-50% of sodium hyaluronate, 10-80% of an oil matrix, 0%-30% of a dispersant and 10-50% of a stabilizing agent. The preparation forms include liquid, paste and solid particles. The oil-dispersed sodium hyaluronate related in the invention is prepared by stably and uniformly dispersing water-soluble moisturizing factors, i.e., the sodium hyaluronate, in a micro powder form into the oil matrix, so that the oil-dispersed sodium hyaluronate is convenient for adding into an oil phase or waterless formula of a cosmetic such as a lipstick, a BB cream and a liquid foundation. The oil-dispersed sodium hyaluronate has the efficacy of relieving dry skin due to an oil component, improving makeup-fixing effect and improving stability and lubricity of cosmetics and solves the problem that sodium hyaluronate is difficult to add into cosmetics.

Description

[0001] technical field [0002] The invention relates to the technical field of sodium hyaluronate, in particular to an oil-dispersed sodium hyaluronate, a method for preparing the oil dispersion, and more particularly, an application of the oil dispersion. Background technique [0003] Hyaluronic acid (Hyaluronic Acid, HA for short), also known as hyaluronic acid, is a polymer mucopolysaccharide formed by linearly linking N-acetylglucosamine and D-glucuronic acid disaccharide repeating units. It is an important component that can combine 1000 times its own water molecules. It is known as an ideal natural moisturizing factor in the field of cosmetics and is widely used in various skin care cosmetics. [0004] Different from skin care cosmetics, beauty cosmetics, especially color cosmetics, are mostly oil-soluble ingredients, and some are even anhydrous formulations. Such oil-based cosmetics are likely to cause skin dryness, and appropriate moisturizing factors need to be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/92A61K8/895A61K8/04A61Q19/00A61Q1/04A61Q1/12A61Q1/10A61Q1/08
Inventor 郭学平张晓鸥毛华石艳丽刘爱华
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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