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Method for preparing octacosanol ester through enzyme catalysis

A technology of octacosanol ester and octacosanol, applied in the field of enzyme-catalyzed preparation of octacosanol ester, to achieve the effects of improving bioavailability, increasing fat solubility, and less side reactions

Inactive Publication Date: 2015-04-08
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the shortcomings of octacosanol with high melting point, poor oil solubility and low bioavailability, and develops an enzyme-catalyzed preparation of octacosanol The ester method has the advantages of mild reaction conditions, less side reactions, easy separation, and environmental protection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] After the reaction was completed, the reaction liquid was taken out, lipase and anhydrous sodium sulfate were removed by filtration, isooctane was removed by rotary evaporation, and the crude product of octacosanol ester was obtained. Analysis by high performance liquid chromatography showed that the conversion rate of octacosyl linoleate was 88.9%.

[0025] Example 2

Embodiment 2

[0027] After the reaction was completed, the reaction solution was taken out, lipase and molecular sieves were removed by filtration, and n-hexane was removed by rotary evaporation to obtain the crude product of octacosanol ester. Analysis by high performance liquid chromatography showed that the conversion rate of octacosyl laurate was 83.2%.

[0028] The specific embodiments above are used to explain the present invention, rather than to limit the present invention. Within the spirit of the present invention and the protection scope of the claims, any modification and change made to the present invention will fall into the protection scope of the present invention.

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PUM

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Abstract

The invention discloses a method for preparing octacosanol ester through enzyme catalysis, belonging to the technical fields of foods, medicines, chemical industry, cosmetics and the like. The octacosanol ester is synthesized under the catalytic action of a nonaqueous-phase lipase by taking octacosanol as a raw material and fatty acid as an acyl donor. The method is mild in reaction condition, little in side reaction, simple in separation, environment-friendly and the like. By using the method, the oil solubility of octacosanol can be improved, the bioavailability of octacosanol can be increased, and the actual application range of octacosanol is greatly widened.

Description

technical field [0001] The invention relates to a method for preparing octacosanol ester by enzymatic catalysis, and belongs to the technical fields of food, medicine, chemical industry, cosmetics and the like. Background of the invention [0002] Octacosanol is a naturally occurring higher alkanol. In nature, there is very little free octacosanol, and most of it exists in natural products such as cane wax, bran wax, beeswax, wheat germ oil and insect wax in the form of fatty acid esters. Octacosanol is mainly obtained through the by-products of the saponification dewaxing process. Therefore, most octacosanol currently on the market exists in free form. Free octacosanol consists of hydrophobic hydrocarbon groups and hydrophilic hydroxyl groups. [0003] Octacosanol is a world-recognized functional anti-fatigue substance with high safety. It is reported that the safety of octacosanol is higher than that of table salt, and the LD of octacosanol in mice 50 is 18000 mg / Kg, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64
CPCC12P7/6436
Inventor 何文森刘世豪徐捍山尹吉
Owner JIANGSU UNIV
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