Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nano composite for targeted medicine delivery and treatment response monitoring as well as preparation method and application of nano composite

A nanocomposite and therapeutically responsive technology, applied in the fields of biomedicine and nanomedicine, can solve problems such as poor stability, easy expansion, and restrictions on the application of inorganic multifunctional nanomaterials, and achieve easy control of size and shape and high sensitivity Effect

Inactive Publication Date: 2015-04-08
SUN YAT SEN UNIV
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polymeric nanomaterials are usually hydrophobic, tend to aggregate in aqueous solution, and easily swell with pH changes, these properties greatly limit the application of polymeric multifunctional nanomaterials in biomedicine
However, inorganic nanomaterials are not easy to prepare, the surface modification method is not perfect, the stability is not good, and there is certain toxicity. These properties limit the application of inorganic multifunctional nanomaterials in biomedicine to a certain extent.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nano composite for targeted medicine delivery and treatment response monitoring as well as preparation method and application of nano composite
  • Nano composite for targeted medicine delivery and treatment response monitoring as well as preparation method and application of nano composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Nanocomplexes for targeted drug delivery and monitoring of therapeutic response were prepared by the following steps:

[0044] Step 1: Preparation of silica fluorescent nanoparticles with a diameter of 60 nm: Add 7.5 mL cyclohexane, 1.77 mL TX-100, 1.8 mL n-hexanol and 340 μL redistilled water into a 50 mL round bottom flask. After uniform stirring for 20 minutes, the reaction system formed a water-in-oil microemulsion system, and then slowly added 80 μL 0.1mol / L bipyridyl ruthenium hydrate and 100 μL tetramethoxysiloxane dropwise to the mixture, and after 30 minutes of reaction, added Siloxane was hydrolyzed with 60 μL of 28% ammonia. After reacting at room temperature for 24 hours, 50 μL of tetramethoxysiloxane and 50 μL of CTES (carboxyethylsilanetriol) were added, followed by further reaction at room temperature for 24 hours. After the reaction was completed, 20 mL of acetone was added to the reaction system to break the emulsion, followed by ultrasonication, vorte...

Embodiment 2

[0054] Another nanocomplex for targeted drug delivery and monitoring of therapeutic response was prepared by the following steps:

[0055] Step 1: Preparation of fluorescent silica nanoparticles with a diameter of 50 nm: Add 7.5 mL of cyclohexane, 1.77 mL of TX-100, 1.8 mL of n-hexanol and 340 μL of redistilled water into a 50 mL round bottom flask. After uniform stirring for 20 minutes, the reaction system formed a water-in-oil microemulsion system, and then slowly added 80 μL of 0.3 mg / L green fluorescent carbon dot aqueous solution (maximum emission wavelength 520 nm) and 100 μL of tetramethoxysiloxane to the mixture After reacting for 30 minutes, 60 μL of 28% ammonia water was added to hydrolyze the siloxane. After reacting at room temperature for 24 h, 30 μL of tetramethoxysiloxane and 30 μL of CTES (carboxyethylsilanetriol) were added, followed by further reaction at room temperature for 18 h. After the reaction was completed, 20 mL of acetone was added to the reaction ...

Embodiment 3

[0062] Another nanocomplex for targeted drug delivery and monitoring of therapeutic response was prepared by the following steps:

[0063] Step 1: Preparation of silica fluorescent nanoparticles with a diameter of 80 nm: Add 7.5 mL of cyclohexane, 1.77 mL of TX-100, 1.8 mL of n-hexanol and 340 μL of redistilled water into a 50 mL round bottom flask. After uniform stirring for 20min, the reaction system formed a water-in-oil microemulsion system, and then slowly added 80 μL 0.3mg / L iridium complex ([Ir(bzq) 2 [bpy(OH) 2 ]]Cl maximum emission wavelength 530nm) and 100 μL tetramethoxysiloxane, reacted for 30 minutes, then added 60 μL 28% ammonia water to hydrolyze the siloxane. After reacting at room temperature for 24 h, 100 μL of tetramethoxysiloxane and 100 μL of CTES (carboxyethylsilanetriol) were added, followed by further reaction at room temperature for 30 h. After the reaction was completed, 20 mL of acetone was added to the reaction system to break the emulsion, follow...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a nano composite for targeted medicine delivery and treatment response monitoring as well as a preparation method and an application of the nano composite. The nano composite is a composite obtained by performing incubation reaction on a gold nanoparticle modified by a first biomolecule and a silicon dioxide fluorescent nanoparticle modified by a second biomolecule which is complementary with the first biomolecule. The invention aims to provide a nano composite for targeted medicine delivery and treatment response monitoring, which can be used for simultaneously realizing three functions of cell imaging, synchronous therapy and real-time monitoring treatment, as well as a preparation method and an application of the nano composite.

Description

technical field [0001] The present invention relates to the fields of biomedicine and nanomedicine, and more specifically, relates to a nanocomposite for targeted drug delivery and monitoring treatment response, a preparation method thereof, and an application of the nanocomposite. Background technique [0002] Nanomaterials provide a robust scaffold that enables two or more components to be combined to provide a multifunctional nanomedicine platform with synergistic effects. Components used for targeted recognition (such as antibodies, nucleic acid recognition ligands or peptides, etc.), imaging components (such as organic dyes, quantum dots, etc.), cell penetration components (such as receptor binding peptides, etc.) on the surface assembly of nanoparticles etc.), while the therapeutic components and components for controlling drug release are embedded in nanoparticles, thereby assembling a multifunctional nanomedicine platform. These multifunctional nanocomplexes are exp...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K41/00A61K47/48A61P35/00
Inventor 易长青潘益张肇敏
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com