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Method for preparing cyclocarya paliurus extract with antioxidant activity and application with cyclocarya paliurus extract as aldose reductase inhibitor

A technology of antioxidant activity and extract, applied in the field of medicine, can solve problems such as no research reports

Active Publication Date: 2015-04-08
WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its inhibitory effect on AR and its use in the prevention and treatment of diabetic complications by intervening in oxidative stress and inhibiting AR have not been reported at home and abroad.

Method used

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  • Method for preparing cyclocarya paliurus extract with antioxidant activity and application with cyclocarya paliurus extract as aldose reductase inhibitor
  • Method for preparing cyclocarya paliurus extract with antioxidant activity and application with cyclocarya paliurus extract as aldose reductase inhibitor
  • Method for preparing cyclocarya paliurus extract with antioxidant activity and application with cyclocarya paliurus extract as aldose reductase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] A method for preparing Cyclocarya paliurus extract with antioxidant activity, comprising the steps of:

[0107] (1) Pulverization: the leaves of Cyclocarya paliurus are dried at 70°C, pulverized by a pulverizer, and passed through a 40-mesh sieve;

[0108] (2) Soaking: soak in water for 10 hours according to the weight ratio of medicinal materials and water at 1:10;

[0109] (3) Extraction: The mixed solution of step (2) was ultrasonically treated with 400W power for 30 minutes at a temperature of 45°C; while it was hot, it was filtered with four layers of 200-mesh filter cloth, and then suction filtered with a Buchner funnel to collect the filtrate and add 1 %-3% ​​activated carbon decolorization, concentrated under reduced pressure; the pressure is -0.09MPa, the temperature is 70°C, and concentrated to 1 / 12 of the original volume.

[0110] (4) Freeze-drying: Freeze-dry at -15°C and -0.01kPa to obtain tan powder, which is the extract of Cyclocarya paliurus with antiox...

Embodiment 2

[0118] A method for preparing Cyclocarya paliurus extract with antioxidant activity, comprising the steps of:

[0119] (1) Pulverization: the leaves of Cyclocarya paliurus are dried at 75°C, pulverized by a pulverizer, and passed through a 40-mesh sieve;

[0120] (2) Soaking: soak in water for 12 hours according to the weight ratio of medicinal materials and water at 1:30;

[0121] (3) Extraction: The mixed solution of step (2) was ultrasonically treated with 500W power for 40 minutes, and the temperature was 50°C; while it was hot, it was filtered with four layers of 200-mesh filter cloth, then suction filtered with a Buchner funnel, the filtrate was collected, and 1% Decolorize with -3% activated carbon, concentrate under reduced pressure; pressure is -0.09MPa, temperature is 70°C, concentrate to 1 / 10 of the original volume.

[0122] (4) Freeze-drying: Freeze-dry at -20°C and -0.01kPa to obtain brown powder, which is the extract of Cyclocarya paliurus with antioxidant activ...

Embodiment 3

[0130] A method for preparing Cyclocarya paliurus extract with antioxidant activity, comprising the steps of:

[0131] (1) Pulverization: the papaya paliurus leaves are dried at 80°C, pulverized by a pulverizer, and passed through a 40-mesh sieve;

[0132] (2) Soaking: soak in water for 14 hours according to the weight ratio of medicinal materials and water at 1:20;

[0133] (3) Extraction: The mixed solution of step (2) was ultrasonically treated with 600W power for 50 minutes at a temperature of 55°C; while it was hot, it was filtered with four layers of 200-mesh filter cloth, and then filtered with a Buchner funnel to collect the filtrate and add 1% Decolorize with -3% activated carbon, concentrate under reduced pressure; pressure is -0.09MPa, temperature is 70°C, concentrate to 1 / 10 of the original volume.

[0134] (4) Freeze-drying: Freeze-dry at -25°C and -0.01kPa to obtain a tan powder, which is the extract of Cyclocarya paliurus with antioxidant activity

[0135] The...

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Abstract

The invention discloses a method for preparing cyclocarya paliurus extract with antioxidant activity and application with the cyclocarya paliurus extract as aldose reductase inhibitor. The method includes the steps of smashing, soaking, extracting and freeze drying. Compared with a traditional heat reflux extraction method, the ultrasonic extraction method which is adopted is less in effectively constituent damage, high in extraction rate, short in extraction time and low in energy consumption. The obtained extract has the good antioxidant and aldose reductase restraining effects, the restraining mechanism for the aldose reductase is an uncompetitive restraining mechanism, and the extract has the prospects of preventing or treating diabetic complications including diabetic nephropathy, diabetic neuropathy, diabetic eye diseases and the like. As natural extract, the cyclocarya paliurus extract has the advantages that the cyclocarya paliurus extract is fewer in side effect and high in safety and activity, and the process is simple and convenient.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for preparing Cyclocarya paliurus extract with antioxidant activity and the application of the prepared extract as an aldose reductase inhibitor. Background technique [0002] Diabetes mellitus (DM) is a group of lifelong metabolic diseases characterized by chronic hyperglycemia caused by multiple etiologies. Diabetes itself does not necessarily cause harm, but long-term blood sugar increases, large blood vessels and microvessels are damaged and endangers the heart, brain, kidney, peripheral nerves, eyes, feet, etc. According to the statistics of the World Health Organization, there are more than 100 complications of diabetes, which is currently the A disease with the most known complications. For this reason, the prevention of complications of diabetes is a crucial social issue. [0003] At present, the treatment of diabetic complications depends on the control of bl...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61P39/06
Inventor 王晓红
Owner WEIFANG MEDICAL UNIV
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