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Traditional Chinese medicine composition for treating septic shock complicated with multiple organ dysfunction syndrome

A technology for septic shock and insufficiency, applied in the direction of drug combination, anti-infective drugs, anti-bacterial drugs, etc., can solve the problems of reducing the mortality rate of septic shock

Active Publication Date: 2016-01-20
JIANGSU PROVINCE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, subsequent multicenter clinical studies found that none of the agents against a single agent achieved the expected efficacy - significantly reducing the mortality rate of septic shock

Method used

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  • Traditional Chinese medicine composition for treating septic shock complicated with multiple organ dysfunction syndrome
  • Traditional Chinese medicine composition for treating septic shock complicated with multiple organ dysfunction syndrome
  • Traditional Chinese medicine composition for treating septic shock complicated with multiple organ dysfunction syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 45 parts by weight of red ginseng, 20 parts by weight of Radix Aconiti, 18 parts by weight of Rhizoma Chuanxiong, 20 parts by weight of Salvia Miltiorrhiza, 12 parts by weight of Pulsatilla, 12 parts by weight of Ophiopogon japonicus, 10 parts by weight of Ophiopogon japonicus, 6 parts by weight of Saffron.

[0027] Preparation of decoction:

[0028]Weigh 18 parts by weight of Ligusticum Chuanxiong and 12 parts by weight of Muxiang and extract the volatile oil by steam distillation at 95-100°C for 3 hours, weigh the dregs after extraction of the above two medicinal materials, 45 parts by weight of red ginseng, 20 parts by weight of Aconite, 20 parts by weight of Salvia miltiorrhiza, 12 parts by weight of Pulsatilla chinensis, 10 parts by weight of Ophiopogon japonicus, 6 parts by weight of saffron, add water and decoct 3 times, 2 hours each time, the amount of water used is 9 times the total weight of the medicinal materials, combined with water and decocted Liquid and ...

Embodiment 2

[0030] 50 parts by weight of red ginseng, 20 parts by weight of Radix Aconiti, 15 parts by weight of Rhizoma Chuanxiong, 22 parts by weight of Salvia miltiorrhiza, 15 parts by weight of Pulsatilla radix, 15 parts by weight of Ophiopogon japonicus, 12 parts by weight of Ophiopogon japonicus, 7 parts by weight of saffron.

[0031] Preparation of granules:

[0032] Weigh 15 parts by weight of Ligusticum chuanxiong and 15 parts by weight of Muxiang, extract the volatile oil by steam distillation at 95-100°C for 3.5 hours, and use β-cyclodextrin and water to clathrate the collected volatile oil for 3 hours, place it for cooling, and dry at low temperature After being ground into fine powder, take the dregs after the above-mentioned 2 kinds of medicinal materials extract and 50 parts by weight of red ginseng, 20 parts by weight of Radix Aconiti, 22 parts by weight of Salvia miltiorrhiza, 15 parts by weight of Pulsatilla radix, 12 parts by weight of Ophiopogon japonicus, 7 parts by we...

Embodiment 3

[0034] 38 parts by weight of red ginseng, 22 parts by weight of Radix Aconiti, 17 parts by weight of Rhizoma Chuanxiong, 20 parts by weight of Salvia miltiorrhiza, 14 parts by weight of Pulsatilla, 14 parts by weight of Ophiopogon japonicus, 15 parts by weight of Ophiopogon japonicus, 8 parts by weight of saffron.

[0035] Preparation of capsules:

[0036] Weigh 17 parts by weight of Ligusticum Chuanxiong and 14 parts by weight of Muxiang, extract the volatile oil by steam distillation at 95-100°C for 4 hours, and wrap the collected volatile oil with β-cyclodextrin and water for 3 hours, place it to cool, and dry at low temperature After that, it is pulverized into a fine powder, and the dregs after the above-mentioned 2 medicinal materials are extracted and 38 parts by weight of red ginseng, 22 parts by weight of Radix Aconiti, 20 parts by weight of Salvia miltiorrhiza, 14 parts by weight of Pulsatilla radix, 15 parts by weight of Ophiopogon japonicus, 8 parts by weight of Pan...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating septic shock and accompanying multi-organ dysfunction syndrome. The traditional Chinese medicine composition is prepared from the combination of red ginseng, radix aconiti lateralis preparata, ligusticum wallichii, salvia miltiorrhiza, pulsatilla chinensis, radix aucklandiae, radix ophiopogonis and crocus sativus which synergistically act to play the effects of effectively clearing heat and removing toxicity, strengthening healthy energy and tonifying Qi, and promoting blood circulation to remove blood stasis so as to reach the purpose of treating septic shock and accompanying multi-organ dysfunction syndrome. The traditional Chinese medicine composition is accurate in treatment effect, free of toxic and side effects, outstanding in treatment effect and high in potential clinical application value, and reaches total effective rate exceeding 85.00%.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation thereof for treating septic shock complicated with multiple organ dysfunction syndrome, and belongs to the technical field of traditional Chinese medicine. technical background [0002] In the past 60 years, great progress has been made in the development and application of antibiotics and clinical treatment measures. The incidence rate is still increasing, especially in areas with backward medical conditions in my country, and the mortality rate of patients with septic shock is still as high as 40-60%. Modern studies have shown that septic shock (refractory hypotension) and subsequent multiple organ dysfunction syndrome (multiple organdysfunction syndrome, MODS) is the main cause of death in patients with sepsis. [0003] MODS refers to a clinical syndrome in which two or more organ dysfunctions occur simultaneously or successively in the body under conditions of sev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P31/00A61P9/00A61P31/04A61P13/12A61P11/00A61P25/00A61P1/00A61P1/16
CPCA61K9/0095A61K9/1652A61K9/2059A61K9/4866A61K36/236A61K36/258A61K36/285A61K36/537A61K36/71A61K36/714A61K36/88A61K36/8968A61K2236/331A61K2236/39A61K2300/00
Inventor 陈彦陆晓张恒东朱莺
Owner JIANGSU PROVINCE HOSPITAL
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