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Pharmaceutical composite for preventing and curing 2-type diabetes and preparation method thereof

A technology for type 2 diabetes and drugs, applied in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc. Urine volume, the effect of suppressing insulin resistance

Active Publication Date: 2012-02-01
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned Chinese patent medicines have a certain curative effect on diabetes and its chronic complications, they generally have defects such as low technical content, backward dosage form, large dosage, low bioavailability, slow onset of effect, and unstable curative effect.

Method used

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  • Pharmaceutical composite for preventing and curing 2-type diabetes and preparation method thereof
  • Pharmaceutical composite for preventing and curing 2-type diabetes and preparation method thereof
  • Pharmaceutical composite for preventing and curing 2-type diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] The preparation method of the pharmaceutical combination of the present invention comprises the following steps:

[0023] ①, firstly prepare total flavonoids of pueraria, get the original medicinal pieces of pueraria, add 12 times the amount of 80% ethanol and heat under reflux for 2 times, each time for 2 hours, filter the dregs, merge the filtrate, and the obtained filtrate is subjected to decompression and recovery of ethanol to obtain medicinal liquid; AB-8 macroporous resin was adsorbed on the above medicinal solution, the loading concentration was 0.1 g crude drug / ml, the loading volume was 10 BV, the flow rate was 1 ml / min, pre-adsorption for 2 hours, re-adsorption for 2 times, and then the adsorption site was washed with water until No reducing sugar reaction; the adsorption site is eluted with 50% ethanol at a volume of 10 BV, the flow rate is 2ml / min, the ethanol solution is recovered under reduced pressure, and after freeze-drying, it is pulverized into 14-mes...

example 1

[0026] Example 1 (hard capsule):

[0027] Take 50g total flavonoids of Pueraria lobata, 25g total astragalus saponins, add 100g dextrin, add starch to 250g, mix well, spray with 40% ethanol to moisten, make into granules, dry below 60 ℃, sieve, put into No. 1 capsule, make 1000 hard capsules (0.25g / capsule). Dosage: 2 capsules each time, 2 times a day.

example 2

[0028] Example 2 (tablet):

[0029]Take 50g total flavonoids of Pueraria lobata, 25g total astragalus saponins, add 100g dextrin, add starch to 200g, mix well to make granules, dry below 60°C, press into 1000 tablets (0.20g / tablet), coat with film, and get . Dosage: 2 tablets each time, 2 times a day.

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Abstract

The invention provides a pharmaceutical composition for preventing and treating type II diabetes and a preparation method thereof. The pharmaceutical composition for preventing and treating the type II diabetes is composed of pharmaceutical raw materials of 40-50 parts by weight of total flavonoids of kudzuvine root and 20-25 parts by weight of total saponins of membranous milkvetch root. The pharmaceutical composition has the effects of benefiting qi, nourishing yin, promoting fluid production and quenching thirsty, the pharmacological studies show that the pharmaceutical composition has the roles of reducing blood sugar, improving glucose tolerance, reducing urine volume, suppressing insulin resistance, lowering lipids and reducing body weight, and the pharmaceutical composition can be used for preventing and treating the type II diabetes.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a medicine combination for preventing and treating type 2 diabetes. Background technique [0002] Diabetes Mellitus (DM) usually refers to type 2 diabetes mellitus (T2DM), which accounts for more than 90% of the total number of DM. The third major category of diseases that seriously threaten human health after vascular diseases and tumors. Its clinical manifestations are metabolic disorder syndrome, such as "three more and one less": polyuria, polydipsia, polyphagia and weight loss. Serious complications can occur in the later stage of diabetes, which are mostly manifested as infection, diabetic nephropathy, diabetic retinopathy, cataract, neuropathy and ketoacidosis. The harm to the human body far exceeds that of diabetes itself, so diabetes is also called "The source of all diseases". With the improvement of people's living standards in our country, the change of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P3/10
Inventor 高英赖小平王春怡
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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