A kind of prescription of compound amoxicillin breast injection and its preparation method

Abstract

The invention relates to a compound amoxicillin breast injection composition and a preparation method thereof, comprising a suspending agent, an antioxidant and a solid dispersion carrier, and a white to off-white oily suspension prepared through a special process. The invention has the advantages of simple preparation process, stable content, easy injection and the like. The composition of the present invention is compounded with amoxicillin, potassium clavulanate, and prednisolone. Compared with other amoxicillin patent preparations, it has obvious antibacterial effect on bacteria resistant to penicillins, and it is effective against Klebsiella Chromosome enzymes produced by Bacillus, Proteus vulgaris, and Bacteroides fragilis also have a strong inhibitory effect; prednisolone has anti-inflammatory and anti-allergic effects, and has a synergistic effect on bacterial infection and allergic inflammation.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a compound amoxicillin breast injection formulation and a preparation method thereof. Background technique [0002] Cow mastitis is one of the diseases that cause the most serious losses in the dairy industry worldwide. In the United States alone, the annual loss caused by cow mastitis reaches 200 million U.S. dollars, which seriously restricts the development of the dairy industry. Between 30% and 70% of cows in the United States have at least one udder infected. The incidence of mastitis in dairy cows in my country is higher. According to the survey results of Yuan Yonglong and others, the average incidence rate of clinical mastitis is 33.41%, the average positive rate of recessive mastitis is 73.91%, and the prevalence rate of milk chamber is 44.74%. Therefore, mastitis causes huge losses such as increased treatment costs, decreased milk production, and premature c...

AI Technical Summary

Problems solved by technology

[0007] In the existing patented technology, the lactating breast injection is a traditional Chinese medicine, which acts slowly and has a slow curative effect. The preparation is prone to tannic acid precipitation, and some prescriptions contain water. After a long period of storage, stratification will occur. Disadvantages such as shaking first

This type of dosage form does not mix the main ingredients evenly, which can easily lead to excessive local drug dosage, or the content of the drug decreases due to demulsification, and there are many problems such as the precipitation of insoluble crystals after the temperature is lowered.

[0008] The dosage form of "a dry dairy cow udder perfusion agent for preventing and treating dairy cow mastitis and its preparation method (CN1286463C; publication date: September 14, 2005)" is a perfusion agent, and polysorbate is required in the preparation process of the solution. Water, etc., have the disadvantages that the active ingredients are easily damaged after demulsification, require high transportation and storage conditions, and cannot protect the teats of dairy cows, etc.

[0009] "A veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and its preparation method (101953784A; publication date: 2011-01-26), the composition of this patent contains Myxobacterium sulfate However, compared with clavulanate potassium, the data show that the anti-drug resistance effect is not as good as the latter. In addition, colistin sulfate has obvious toxicity to the kidney and nervous system, and is a low-toxicity drug. If the animal has renal insufficiency, then easily accumulate in the kidney

Images