Targeted amphipathic nano-drug microcapsule

Abstract

The invention discloses a targeted amphipathic nano-drug microcapsule which is prepared through following steps: (1) polymerizing phosphatidylcholine through an atom transfer radical polymerization method to obtain poly-phosphatidylcholine; (2) modifying the poly-phosphatidylcholine with a folic acid molecule; (3) polymerizing octadecyl glutamate carboxylic acid anhydride through a ring-opening polymerization method to obtain poly-octadecyl glutamate; (4) performing stem-grafting to the poly-octadecyl glutamate with adriamycin through a hydrazone bond; (5) performing a bond-connecting process to the poly-phosphatidylcholine and the poly-octadecyl glutamate in a click chemical manner to obtain a segmented copolymer; (6) dissolving the segmented copolymer in tetrahydrofuran and moving the solution to a dialysis bag, performing dialysis with pure water, and filtering a dialyzate through a filter membrane; and (7) freeze-drying a solution after filtration to obtain a medicine carrying micelle. The medicine carrying micelle has a double-layer core-shell structure of which an outer layer is hydrophilic poly-phosphatidylcholine and an inner layer is a drug molecule wrapping layer. The microcapsule belongs to nano-particles, can achieve targeted transmission of the drug and pH-sensitive releasing in cancer cells, is large in drug carrying amount and is good in stability. The targeted function can reduce toxic and side effects of the drug on normal tissue and organ.

Description

technical field [0001] The invention relates to a targeting amphiphilic nano drug microcapsule, in particular to a preparation method of a block polymer material drug carrier microcapsule with cancer cell targeting. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Cancer has become the most important disease that endangers human health. One of the important methods to treat cancer is drug therapy. However, many anticancer drugs have defects such as insoluble in water and poor stability. For example, camptothecin, paclitaxel, doxorubicin, and 5-fluorouracil are difficult to be well utilized by organisms due to their poor solubility. Solving the problem of their water solubility is the key to the clinical application of such pharmaceutical preparations. In addition, most of the tumor treatment and diagnostic drugs have non-selective effects, and are often distributed in some normal tissues and organs, and the therap...

AI Technical Summary

Problems solved by technology

[0006] However, due to the complex structure of the polymer in the star polymer, the prepared drug carrier has problems such as poor biocompatibility, decreased drug loading capacity, and reduced water solubility of drug molecules on the surface of dendrimer.

In addition, dendrimer has a complex structure and high synthesis cost

These problems limit the application of star-shaped polymer nano-drug delivery system

Images