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Drug for treating rheumatic arthritis through oral taking and external application and preparation method of drug

A rheumatoid arthritis, combining internal and external technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of large toxic and side effects, difficult for patients to accept, and taking medicine for a long time, and achieve exact curative effect and small toxic and side effects.

Inactive Publication Date: 2015-03-04
徐鸿雁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no good therapeutic method for Western medicine treatment of rheumatoid arthritis. Its main purpose is to relieve pain and control the progress of the disease. Drugs, etc., are often difficult for patients to accept due to the long time of taking the medicine and the large toxic and side effects

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0069] Wherein, when the dosage form of described internal medicine is capsule, its preparation method comprises the following steps:

[0070]The first step is to mix Morinda officinalis, Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome, Achyranthes bidentata, Gentiana chinensis and Wood Beetle according to the stated ratio, add 8-10 times of water relative to the mixture to extract the volatile oil, and use β-cyclodextrin to obtain the volatile oil Inclusion, the ratio of volatile oil to β-cyclodextrin is 1:4~8, stir for 2~3 hours, the temperature is 40°C~60°C, get the inclusion compound of volatile oil, set aside; in addition, concentrate the water extract to 70°C Clear paste with a relative density of 1.24 to 1.26;

[0071] The second step is to mix Fangfeng, Bupleurum, White Mustard Seed, Bombyx mori, leech and centipede according to the stated ratio, add ethanol with an ...

Embodiment 1

[0091] Embodiment 1 capsule (medicine for oral administration)

[0092] Take 200g of Morinda officinalis, 220g of drynaria, 260g of Achyranthes bidentata, 130g of Gentiana chinensis, 60g of wood beetle, 300g of angelica, 160g of white peony root, 240g of clematis, 160g of xugufeng, 310g of licorice, 120g of duhuo, 180g of cassia twig, Fangfeng 130g, Bupleurum 210g, White Mustard Seed 150g, Silkworm 130g, Leech 240g and Centipede 70g;

[0093] Its preparation method comprises the following steps:

[0094] The first step is to mix Morinda officinalis, Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome, Achyranthes bidentata, Gentiana chinensis and Wood Beetle according to the stated ratio, add 9 times of water relative to the mixture to extract the volatile oil, and clathrate the obtained volatile oil with β-cyclodextrin , the ratio of volatile oil to β-cyclodextrin is 1:6, stirred for 2 hours at a temperature of 55°C to obtain a vol...

Embodiment 2

[0099] Embodiment 2 patch (medicine for external use)

[0100] Take 300g of Daokoucao, 380g of Oxtail, 140g of Jiujiefeng, 210g of Stephania vine, 270g of Pearl Ginseng, 330g of Yunxiangcao, 110g of Wingweed, 220g of Sperancus, 90g of Dinggongteng, 270g of Shenjincao and 320g of Five-clawed Golden Dragon;

[0101] Its preparation method comprises the following steps:

[0102] In the first step, the mixture 1 is obtained by mixing the grass, oxtail, jiujiefeng and Stephania vine according to the stated ratio, adding ethanol with an alcohol concentration of 85% that is 5 times the mass of the mixture 1, and extracting after heating and reflux for 3 hours. Filtrate to get the first filtrate; add the ethanol of 3 times the alcohol concentration 95% of the mass of the mixture to the filter residue again to dissolve, extract after heating and reflux for 2 hours, filter to get the second filtrate; combine the first filtrate and the second Filtrate, reclaim ethanol under reduced pres...

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PUM

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Abstract

The invention provides a drug for treating rheumatic arthritis through oral taking and external application and a preparation method of the drug. The drug comprises an orally-taken drug and an externally-applied drug, wherein the orally-taken drug comprises the following raw medicinal materials: radix morindae officinalis, rhizoma drynariae, achyranthes bidentata, radix gentianae macrophyllae, ground beetle, angelica, radix paeoniae alba, radix clematidis, wooly datchmanspipe herb, liquorice, radix angelicae pubescentis, cassia twig, radix saposhnikoviae, radix bupleuri, white mustard seeds, bombyx batryticatus, hirudo and scolopendra; the externally-applied drug comprises the following raw medicinal materials: common achyranthes herb, root and rhizome of ripqrian greenbrier, all grass of serrulate clearweed, Japanese stephania root, rhizome of largeleaf Japanese ginseng, vanilla, herba polygoni orientalis, herb of tuberculate speranskia, caulis erycibes, herba lycopodii and root or all-grass of cairo morningglory. The drug has the beneficial effects that by being orally taken and externally applied, the drug has a definite treating effect to the rheumatic arthritis and is low in toxic and side effects.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a medicine for treating rheumatoid arthritis with internal and external combination and a preparation method. Background technique [0002] Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue. Can be recurrent and involve the heart. Clinically, it is characterized by migratory soreness, weight, and pain in joints and muscles. An allergic disease. It is one of the main manifestations of rheumatic fever, mostly with acute fever and arthralgia onset. [0003] Rheumatoid arthritis is a manifestation of rheumatic fever. Rheumatic fever is a systemic allergic disease caused by group A beta-hemolytic streptococcus infection, and there are often infection medical histories such as erysipelas at the beginning of the disease. Rheumatic fever has a sudden onset and is more common in adolescents. Rheu...

Claims

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Application Information

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IPC IPC(8): A61K36/746A61K36/896A61K36/899A61P19/02A61P29/00A61K35/62A61K35/64A61K35/648
CPCA61K9/0014A61K9/28A61K9/4866A61K9/7023A61K35/62A61K35/648A61K36/11A61K36/126A61K36/185A61K36/21A61K36/232A61K36/233A61K36/238A61K36/258A61K36/264A61K36/31A61K36/39A61K36/47A61K36/484A61K36/51A61K36/54A61K36/59A61K36/65A61K36/704A61K36/71A61K36/716A61K36/746A61K36/87A61K36/896A61K36/899A61K47/10A61K47/36A61K47/44A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 薛君栾英杰许梅华张晓燕顾维乐薛卫强陈勋
Owner 徐鸿雁
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