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A compound for improving the anti-infection ability of implants and its preparation method and application

An anti-infection and compound technology, applied in the direction of ruthenium organic compounds, platinum group organic compounds, chemical instruments and methods, etc., can solve the problems of antibiotic treatment, removal of implant death, high infection rate, and achieve excellent antibacterial properties and easy availability of raw materials. , the effect of low cost

Active Publication Date: 2017-04-12
陕西专壹知识产权运营有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Implant materials such as dental implants and bone implants have become an important repair method for dentition defects and bone loss, however, the infection rate of this type of surgery is high, which can lead to serious consequences such as heavy antibiotic treatment, removal of implants and even death

Method used

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  • A compound for improving the anti-infection ability of implants and its preparation method and application
  • A compound for improving the anti-infection ability of implants and its preparation method and application
  • A compound for improving the anti-infection ability of implants and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The compound used to improve the anti-infection ability of the implant described in the present invention is an aryl ruthenium complex, and its chemical name is monochloro-chloro-p-fluorinated benzene-2-condensed N 4 -Phenylthiosemicarbazide-methylcymenylruthenium(II);

[0035] Its structural formula is:

[0036]

[0037] Its physical and chemical properties are: dark red crystal, easily soluble in water and organic solvents.

[0038] Chlorine-to-fluorinated benzene-2-condensate N of the present invention 4 - the preparation method of phenylthiosemicarbazide-cymene ruthenium (II), its concrete steps are as follows:

[0039] Step 1, 65 parts by weight of ruthenium trichloride hydrate with a ruthenium weight content of 37% and 470 parts by weight of gamma-terpinene with a purity of 95% are dissolved in 1450 parts by weight of dehydrated alcohol, heated to reflux and stirred for 6 hours, static Set out to obtain the compound with formula (III), i.e. dichloro-dichloro...

Embodiment 2

[0045] The compound used to improve the anti-infection ability of the implant described in the present invention is an aryl ruthenium complex, and its chemical name is monochloro-chloro-p-fluorinated benzene-2-condensed N 4 -Phenylthiosemicarbazide-methylcymenylruthenium(II);

[0046] Its structural formula is:

[0047]

[0048] Its physical and chemical properties are: dark red crystal, easily soluble in water and organic solvents.

[0049] Chlorine-to-fluorinated benzene-2-condensate N of the present invention 4 - the preparation method of phenylthiosemicarbazide-cymene ruthenium (II), its concrete steps are as follows:

[0050]Step 1, 70 parts by weight of ruthenium trichloride hydrate with a ruthenium weight content of 37% and 480 parts by weight of gamma-terpinene with a purity of 95% are dissolved in 1500 parts by weight of dehydrated alcohol, heated under reflux and stirred for 6 hours, static Set out to obtain the compound with formula (III), i.e. dichloro-dichlo...

Embodiment 3

[0056] The compound used to improve the anti-infection ability of the implant described in the present invention is an aryl ruthenium complex, and its chemical name is monochloro-chloro-p-fluorinated benzene-2-condensed N 4 -Phenylthiosemicarbazide-methylcymenylruthenium(II);

[0057] Its structural formula is:

[0058]

[0059] Its physical and chemical properties are: dark red crystal, easily soluble in water and organic solvents.

[0060] Chlorine-to-fluorinated benzene-2-condensate N of the present invention 4 - the preparation method of phenylthiosemicarbazide-cymene ruthenium (II), its concrete steps are as follows:

[0061] Step 1, 69 parts by weight of ruthenium trichloride hydrate with a ruthenium weight content of 37% and 478 parts by weight of gamma-terpinene with a purity of 95% are dissolved in 1480 parts by weight of dehydrated alcohol, heated under reflux and stirred for 6 hours, static Set out to obtain the compound with formula (III), i.e. dichloro-dichl...

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Abstract

The invention discloses a compound for enhancing anti-infection capacity of plants disclosed as structural formula (I), and a preparation method and application thereof. The chemical name is monochlorinated-chloro-p-fluoridated-phenyl-2-N<4>-phenylthiosemicarbazidomonomethylisopropylbenzo ruthenium (II). The compound has strong bactericidal activity for Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) and Bacillus subtilis black variant (ATCC 9372), has the advantages of excellent mold resistance and no toxicity, has the function of promoting growth of osteoblasts, is used for preparing drugs for enhancing plant performance and preventing plant related infections, and has obvious application potential. The preparation method is simple, and has the advantages of accessible raw materials and low cost.

Description

technical field [0001] The invention relates to the field of compound preparation, in particular to an aryl ruthenium complex for improving the anti-infection ability of implants, a preparation method and application thereof. Background technique [0002] Implant materials such as dental implants and bone implants have become an important repair method for dentition defects and bone loss. However, this type of surgery has a high infection rate, which may lead to serious consequences such as heavy antibiotic treatment, implant removal and even death. There are two main reasons for the high incidence of implant-associated infection: the accumulation of bacterial plaque on the implant surface and the low resistance of the implant osseointegration interface. In order to avoid implant-associated infection, the graft should have excellent properties in two aspects: excellent antibacterial properties and the function of promoting osteoblast growth. Therefore, it is necessary to fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00A61K31/555A61P31/04A61P31/10A61P1/02A61P19/08
CPCC07F15/0046Y02A50/30
Inventor 李培源苏炜霍丽妮陈睿
Owner 陕西专壹知识产权运营有限公司
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