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Production process of secondary extraction of heparin sodium from enzymatic desorption and adsorption waste liquid

A technology for secondary extraction and production process, applied in the field of production technology for secondary extraction of heparin sodium, can solve the problems of incomplete hydrolysis and adsorption, polluted environment, environmental pollution, etc., and achieves low reaction temperature requirements, low production energy consumption, The effect of high product purity

Active Publication Date: 2016-04-06
重庆市友谊畜产品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the expansion of the scale of heparin sodium production enterprises, a large amount of enzyme desorption and adsorption waste liquid is directly discharged at will, causing environmental pollution; at the same time, due to the incomplete hydrolysis and adsorption in the traditional production process, the waste liquid also contains about 40% heparin sodium If it is not extracted, the waste liquid is a waste of resources and pollutes the environment. How to further extract heparin sodium from the waste liquid and turn waste into treasure has become an urgent problem for the majority of heparin sodium producers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] ①Flocculation reaction: Take 10 tons of fresh enzyme desorption waste liquid and input it into the reaction tank, add 3wt‰ composite flocculant composed of sodium benzoate, polyvinyl ammonium and pentonite at a ratio of 10:1:1 and 1wt‰toluene , stir the mixed solution at a speed of 100r / min for 5min, add hydrogen chloride to adjust the pH value to 5.5, stir for another 5min, add sodium hydroxide to adjust the pH value to 6.8, stir for 5min, let stand at room temperature for 2 hours, and take out the supernatant for later use. The precipitate is sent to a centrifuge for centrifugation at a centrifugal speed of 5000r / min, the supernatant obtained by centrifugation is mixed with the spare supernatant, and sodium hydroxide is added to adjust the pH value to 10, and the pH value is adjusted again after standing for 2 hours. 7. Leave to settle for 2 hours, take out the standing supernatant and send it to an ultrafilter, and send the sediment obtained by the centrifuge and the ...

Embodiment 2

[0020] ① Flocculation reaction: Take 10 tons of fresh enzyme desorption waste liquid and input it into the reaction tank, add 4wt‰ sodium benzoate, polyvinyl ammonium, potassium alginate, calcium chloride and pentonite according to the ratio of 10:1:1:1:1 Composite flocculant made of components and 1.2wt‰ toluene, stir the mixed solution at a speed of 120r / min for 8 minutes, add sodium hydroxide to adjust the pH value to 6, stir for another 8 minutes, add sodium hydroxide to adjust the pH value to 7.0, and stir for 5 minutes , settling at room temperature for 2.5 hours, pumping out the supernatant for later use, sending the sediment into a centrifuge for centrifugal filtration at a centrifugal speed of 5500r / min, mixing the supernatant obtained by centrifugation with the spare supernatant, and adding hydroxide Adjust the pH value to 10 with sodium, let it settle for 2 hours, adjust the pH value again to 7, let it settle for 2 hours, take out the standing supernatant and send it...

Embodiment 3

[0026] ① Flocculation reaction: Take 10 tons of fresh enzyme desorption waste liquid and input it into the reaction tank, add 5wt‰ of sodium benzoate, polyvinyl ammonium, sodium alginate di-fatty alcohol, alum, perlite crystal powder, barium carbonate and diatom Composite flocculant with 10:0.5:1:1:1:1:1 composition and 1.5wt‰ phenol, stir the mixture at a speed of 150r / min for 10min, add hydrogen chloride to adjust the pH value to 6.5, and then stir 10min, add sodium hydroxide to adjust the pH value to 7.0, stir for 5min, let stand at room temperature for precipitation for 3 hours, take out the supernatant for later use, and send the sediment into a centrifuge for centrifugal filtration at a centrifugal speed of 6000r / min Mix the supernatant with the spare supernatant, add sodium hydroxide to adjust the pH value to 10.5, let it settle for 2 hours, adjust the pH value to 7 again, let it settle for 2 hours, take out the standing supernatant and send it to ultrafiltration machin...

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PUM

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Abstract

The invention relates to a production process for secondary extraction of heparin sodium from enzymolysis adsorption waste liquid. The production process comprises steps of flocculation reaction, ultrafiltration and concentration, alcohol precipitation, purification and refining, wastewater treatment, etc. According to the production process disclosed by the invention, by regulating PH value of fresh enzymolysis waste liquid for several times and adding composite flocculants different in components, free protein in mixed liquid is completely separated out during reaction and most impurities are removed through flocculation and precipitation, thus forming heparin sodium which is high in purity and reasonable in titer; the entire process is scientific and reasonable, low in production cost, short in cycle and not high in requirement on reaction temperature, the produced heparin sodium is high in purity and the extracting rate nearly reaches 100%; and emissions completely meet an environment-friendly emission standard.

Description

technical field [0001] The invention relates to a process for secondary extraction of heparin sodium, in particular to a process for secondary extraction of heparin sodium from pig small intestine mucosal enzyme desorption and adsorption waste liquid. Background technique [0002] Heparin sodium is a mucopolysaccharide sulfate-based anticoagulant drug, which is widely used in clinical use to prevent and treat various cardiovascular and cerebrovascular diseases. It has always been the most effective anticoagulant drug, especially for arteriovenous thrombosis and blood clots. curative effect. Heparin sodium widely exists in the intestinal mucosa, lung, and liver of mammals, especially in the pig small intestinal mucosa, and the heparin extracted from the healthy pig small intestinal mucosa is basically consistent with the molecular structure of heparin in the human body. The production method of heparin sodium in the prior art mainly adopts fresh porcine small intestinal muco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10
Inventor 韩敬冰姚文江
Owner 重庆市友谊畜产品有限公司
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