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Solid phase extraction column and preparation method thereof as well as chemical sample pretreatment method based on solid phase extraction column

A solid-phase extraction column and chemical sample technology, applied in the field of solid-phase extraction, can solve problems such as data distortion, large dosage, and large adsorption degree, and achieve the effect of avoiding data distortion and high-efficiency separation effect

Active Publication Date: 2015-01-07
SINOPHENE NOVEL MATERIALS
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  • Abstract
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Problems solved by technology

[0004] Traditional solid-phase extraction agents have disadvantages such as high packing density, large dosage, large waste and high cost in the analysis process.
The main problem is that due to the large amount of traditional solid-phase extraction agents, the trace components in the sample are adsorbed on the solid-phase extraction agent to a large extent, so they cannot be detected or the true value cannot be detected in the subsequent detection. So the data is distorted

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  • Solid phase extraction column and preparation method thereof as well as chemical sample pretreatment method based on solid phase extraction column
  • Solid phase extraction column and preparation method thereof as well as chemical sample pretreatment method based on solid phase extraction column
  • Solid phase extraction column and preparation method thereof as well as chemical sample pretreatment method based on solid phase extraction column

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preparation example Construction

[0048] A method for preparing a solid-phase extraction column according to one embodiment is used for preparing the above-mentioned solid-phase extraction column. The preparation method of the solid phase extraction column includes the following steps 110 - 120 .

[0049] Step 110: Select one of various solid phase extraction agents to be selected.

[0050] The solid phase extraction agent to be selected is graphene or modified graphene. Wherein, graphene is single-layer graphene or few-layer graphene. The modified graphene is selected from amidated graphene, carboxylated graphene, cyanographene, nitrographene, boronic acid-based graphene, phosphate-based graphene, hydroxylated graphene, mercaptolated graphene, methylated Graphene, allylated graphene, trifluoromethylated graphene, dodecylated graphene, octadecylated graphene, fluorinated graphene, brominated graphene, chlorinated graphene and iodine at least one of graphene.

[0051] In the case of a pure product of the ta...

Embodiment 1

[0091] 1. Select oligolayer graphene as the solid phase extraction agent according to the polarity of the components. The oligolayer graphene is loosely loaded into a polypropylene plastic column with one end sealed with a porous alumina sieve, the volume of the solid phase extraction agent accounts for 1 / 5 of the volume of the polypropylene plastic column, and then another porous A porous alumina sieve plate was used to seal the polypropylene plastic cylinder, and the polypropylene plastic cylinder filled with oligolayer graphene was placed on a shaker to vibrate for 3 minutes, and then the porous alumina sieve plate was lightly pressed to compact the solid phase extraction agent. , to obtain a solid phase extraction column.

[0092] 2. Prepare the working solutions of α-nitronaphthalene, phenol, pentaerythritol, benzoic acid and naphthalene respectively. The solvents are dichloromethane and the concentration is 100ug / L. Add methyl red as impurity components. The concentrati...

Embodiment 2

[0100] 1. Hydroxylated graphene is selected as the solid phase extraction agent according to the polarity of the components. Hydroxylated graphene is loosely loaded into a polypropylene plastic column with one end sealed with a porous alumina sieve, the volume of the solid phase extraction agent accounts for 1 / 8 of the volume of the polypropylene plastic column, and then another porous A porous alumina sieve plate is used to seal the polypropylene plastic cylinder, and the polypropylene plastic cylinder equipped with hydroxylated graphene is placed on a shaker to vibrate for 3 minutes, and then the porous alumina sieve plate is lightly pressed to compact the solid phase extraction agent. A solid phase extraction column was obtained.

[0101] 2. Prepare the working fluids of allyl chloride, acrylamide, acrylic acid and acryl alcohol respectively. The solvents are all methanol, and the concentration is 100ug / L. Then add Jianna Green B as an impurity component. L.

[0102] 3. A...

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Abstract

The invention relates to a solid phase extraction column and a preparation method thereof as well as a chemical sample pretreatment method based on the solid phase extraction column. The solid phase extraction column comprises a separation column and a solid phase extraction agent, wherein the separation column is filled with the solid phase extraction agent; the solid phase extraction agent is graphene or modified graphene; graphene is single-layered graphene or oligo-layered graphene; modified graphene is selected from at least one of aminated graphene, carboxylated graphene, cyano graphene, nitryl graphene, boric acid based graphene, phosphoric acid based graphene, hydroxylated graphene, sulfhydrylated graphene, methylated graphene, allylated graphene, trifluoromethylated graphene, dodecylated graphene, octadecylated graphene, fluorinated graphene, brominated graphene, chlorinated graphene and iodated graphene. The solid phase extraction column is used for pre-treating a chemical sample and can realize efficient separation effect; and the problem that target components cannot be detected in subsequent detection or a real value cannot be detected to cause data distortion is avoided.

Description

technical field [0001] The invention relates to the technical field of solid phase extraction, in particular to a solid phase extraction column, a preparation method thereof and a chemical sample pretreatment method based on the solid phase extraction column. Background technique [0002] In the detection and analysis of chemical samples, especially natural samples, the most common problem is that the components of the samples are mostly too complex to be directly analyzed by chromatography, or the direct analysis effect is not good. Therefore, it is necessary to separate the analyte through pretreatment of the chemical sample, and then perform chromatographic analysis. At present, the most commonly used chemical sample pretreatment technology is solid phase extraction (SPE) technology, that is, the adsorption extraction is realized through the affinity of specific components in the components and the solid phase extraction agent, so as to achieve the separation of specific ...

Claims

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Application Information

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IPC IPC(8): B01D15/22G01N30/60
Inventor 张明东张麟德
Owner SINOPHENE NOVEL MATERIALS
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