A kind of biosensor structure and preparation method thereof

Abstract

The invention discloses a biosensor structure and a preparation method thereof, which comprises a molecular probe (2), the molecular probe (2) is located in a channel (4) of a microfluidic structure, and the upper part of the molecular probe (2) is a sample injection window (7), the upper left side of the microfluidic structure channel (4) is the fluid inlet (5), the lower right side of the microfluidic structure channel (4) is the waste liquid outlet (6), the incident light source interface (1) and the signal receiving interface (3 ) are connected to the molecular probe (2) respectively; the preparation method includes steps such as substrate cleaning, microfluidic structure channel fabrication, molecular probe fabrication and final combination, which solves the problem of the small size of the biosensor device in the prior art. The small temperature drift caused by the probe, the intrinsic vibration caused by the probe being too long, and the probe being too short can not fully absorb the incident light and other shortcomings are not conducive to reducing the volume, reducing the cost and improving the accuracy, and are not easy to commercialize.

Description

technical field [0001] The invention belongs to biosensor technology, in particular to a biosensor structure and a preparation method thereof. Background technique [0002] Tumor is an important killer that threatens human life and health, and has become one of the most important social problems faced by countries all over the world. Early screening and diagnosis are the key to the prevention and treatment of tumor diseases. Current scientific research has shown that in the different stages of tumor development and deterioration, and in the early stage when there are almost no symptoms, the levels of certain tumor marker proteins in human serum have changed, which in turn affects the functions of the human body, manifested as tumors. the occurrence of disease. Rapid and effective detection of these tumor protein markers is the key to the prevention and treatment of tumor diseases. [0003] According to current knowledge, there are more than 100,000 kinds of proteins in the...

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Problems solved by technology

[0005] The technical problem to be solved by the present invention: provide a biosensor structure and its preparation method to solve the micro temperature drift caused by the miniaturization of the biosensor device in the prior art, the intrinsic vibration caused by the probe being too long, the probe It is too short and cannot fully absorb the incident light, which is not conducive to reducing the volume, reducing the cost and improving the accuracy, and is not easy to commercialize. At the same time, multiple sensors can be multiplexed at the same time, which is conducive to the simultaneous realization of multiple samples or the same sample. Real-time measurement of multiple parameters

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