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Double-water-phase extraction method for cistanche deserticola phenylethanoid glycosides

A technology of phenylethanol glycosides and two-phase water, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of low efficiency, low quality, high energy consumption, etc., and achieve high efficiency, good quality, Effect of mild production conditions

Active Publication Date: 2014-12-10
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Based on the above various reasons, the present invention provides a method for ultrasonic-assisted two-phase extraction of phenylethanol glycosides from Cistanche deserticola, which overcomes the shortcomings of high energy consumption, high loss, low efficiency, and low quality of the above method, and provides a new method for the production of phenylethanol glycosides from Cistanche deserticola. Provides a green, low-cost, high-quality production path

Method used

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  • Double-water-phase extraction method for cistanche deserticola phenylethanoid glycosides
  • Double-water-phase extraction method for cistanche deserticola phenylethanoid glycosides
  • Double-water-phase extraction method for cistanche deserticola phenylethanoid glycosides

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Effect test

Embodiment 1

[0038] 1) Crush Cistanche to 20 mesh, and keep it sealed.

[0039] 2) The establishment of a two-phase aqueous system. In this two-phase aqueous system, based on the two-phase aqueous system, the mass fraction of ethanol is 15%, and the fraction of dipotassium hydrogen phosphate is 30%. In the phase system, the ratio of solid to liquid is 1 / 20.

[0040] 3) Extract under stirring for 80 minutes, wherein the extraction temperature is 45°C.

[0041] 4) Take the phenylethanol glycoside-enriched phase, and carry out vacuum distillation on it. The temperature of the vacuum distillation is 40° C., and dipotassium hydrogen phosphate is recovered, and finally vacuum-dried at 40° C. to obtain 0.68 g of phenylethanol glycoside extract of Cistanche deserticola.

Embodiment 2

[0043] 1) Cistanche cistanche is crushed, passed through a 40-mesh sieve and sealed for storage.

[0044] 2) The establishment of a two-phase aqueous system. In this two-phase aqueous system, based on the two-phase aqueous system, the mass fraction of ethanol is 40%, and the fraction of dipotassium hydrogen phosphate is 14%. In the water phase system, the ratio of solid to liquid is 1 / 5.

[0045] 3) Extract under stirring for 80 minutes, wherein the extraction temperature is 45°C.

[0046] 4) Take the phenylethanol glycoside-enriched phase, and carry out vacuum distillation on it, the temperature of the vacuum distillation is 50°C, recover dipotassium hydrogen phosphate, and finally dry it in vacuum at 50°C to obtain the phenylethanol glycoside extract of Cistanche cistanche 1.97g.

Embodiment 3

[0048] 1) Crush Cistanche to 80 meshes, and keep it sealed.

[0049] 2) The establishment of a two-phase aqueous system. In this two-phase aqueous system, based on the two-phase aqueous system, the mass fraction of ethanol is 23%, and the fraction of dipotassium hydrogen phosphate is 22%. 5g of cistanche powder is added to the two-phase aqueous phase In the system, the ratio of solid to liquid is 1 / 40.

[0050] 3) Ultrasonic-assisted extraction for 80 minutes, wherein the extraction temperature is 20°C.

[0051] 4) Take the phenylethanol glycoside-enriched phase and carry out vacuum distillation on it. The temperature of the vacuum distillation is 60° C. to recover dipotassium hydrogen phosphate, and finally vacuum-dry it at 60° C. to obtain 0.99 g of the phenylethanol glycoside extract of Cistanche deserticola.

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Abstract

The invention discloses a double-water-phase extraction method for cistanche deserticola phenylethanoid glycosides. The method comprises the following steps: 1) adding a cistanche deserticola raw material powder into a double-water-phase system; 2) extracting; and 3) transferring a phenylethanoid glycosides enriching phase, concentrating and drying, so as to obtain the cistanche deserticola phenylethanoid glycosides. The method for extracting phenylethanoid glycosides from cistanche deserticola is simple, high in extraction yield, easy for amplified continuous production operation, low in energy consumption, high in phenylethanoid glycosides content in the extract product, and overcomes the disadvantages that conventional method for extracting phenylethanoid glycosides from cistanche deserticola is tedious in operation, time-consuming, low in extraction yield, not high in extracted phenylethanoid glycosides quality, and the like.

Description

technical field [0001] The invention belongs to the field of separation and purification of effective components of natural products, and in particular relates to a process for two-phase extraction of phenylethanol glycosides from Cistanche deserticola. Background technique [0002] Cistanche deserticola Y.C.Ma, also known as Desert Cistanche, Cistanche or Dayun, Sweet Dayun, Cunyun, Haloxylon Dayun, etc., is a perennial parasitic plant of the genus Cistanche (Cistanche Hoffmg.et Link) in the family Orobanchaceae. There are about 20 species of Cistanche, which are distributed in the warm dry or semi-arid regions of Eurasia. Historical research has found 8 species and 1 variant in my country. After the research and investigation by Tu Pengfei and others, it is determined that the current Cistanche in my country is Divided into 4 species including Cistanche tubulosa (Schrenk) Wight, Cistanche deserticola (C.deserticola, Y.C.Ma), Cistanche salsa (C.A.Mey.) G.Beck), Cistanche des...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61K8/97A61P39/06A61P31/12A61P31/04A61P35/00A61P9/00A61P17/16A61P17/14A61P1/10
Inventor 赵兵董贝涛赵庆生袁晓凡
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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