A kind of long-acting benzathine cloxacillin breast injection and preparation method thereof

Abstract

A long-acting cloxacillin benzathine breast injection, consisting of the following raw materials: calculated by weight, cloxacillin benzathine: 3‑20 parts, ethyl oleate: 30‑90 parts, beeswax: 10‑30 parts , Tween‑80: 1‑3 servings. The invention also provides a preparation method of the long-acting benzathine cloxacillin breast injection. A long-acting benzathine cloxacillin breast injection of the present invention has a high effective ingredient inclusion rate, and the microporous structure of beeswax is small, which can play a good slow-release effect, and can extend the effective bacteriostatic concentration to 58 days. The posterior mammary tissue is more elastic, the scar tissue is stable without infiltration, and the smooth muscle function of the nipple is effectively restored. Compared with the existing technology, the treatment effect of mastitis is better. The preparation method effectively retains the effective components of the beeswax, and processing it into microcapsules increases the contact area between the beeswax and breast tissue, and can fully exert the effect of the traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the technical field of benzathine cloxacillin breast injection, in particular to a long-acting benzathine cloxacillin breast injection and a preparation method thereof. Background technique [0002] Dairy cows are modernized and the dry period is 60 days. The dry period is the best treatment period for mastitis and an important stage to prevent infection. During the dry period, antibiotics are usually injected into the breast chamber once. How to maintain the effective antibacterial concentration of intramammary antibiotics for a longer period of time and repair breast tissue damage up to 300 days during lactation is the focus of research on topical administration of intramammary drugs during dry lactation. [0003] Through clinical application, it was found that the effective antibacterial concentration of traditional medicine was only 21 days, and after the application of traditional medicine, the scar tissue infiltrated, wi...

AI Technical Summary

Problems solved by technology

[0003] Through clinical application, it was found that the effective antibacterial concentration of traditional medicine was only 21 days, and after the application of traditional medicine, the scar tissue was infiltrated, with unclear boundaries, poor tissue elasticity, regional inflammatory infiltration, and poor recovery of papillary smooth muscle

Images