Long-acting cloxacillin benzathine breast injectant and preparation method thereof

Abstract

The invention relates to a long-acting cloxacillin benzathine breast injectant. The long-acting cloxacillin benzathine breast injectant is prepared from the following raw materials in parts by weight: 3-20 parts of cloxacillin benzathine, 30-90 parts of ethyl oleate, 10-30 parts of beewax and 1-3 parts of tween-80. The invention also provides a preparation method of the long-acting cloxacillin benzathine breast injectant. The long-acting cloxacillin benzathine breast injectant has the advantages that the inclusion rate of active ingredients of the long-acting cloxacillin benzathine breast injectant is high, a cellular structure of beewax is small, a good sustained release effect can be realized, effective minimal inhibitory concentration can be prolonged to 58 days, breast tissues are more elastic after the long-acting cloxacillin benzathine breast injectant is applied, scar tissues are stable and non-infiltration, functions of smooth muscles of nipples can be effectively restored, and treatment effect on subclinical mastitis is good compared with that of the prior art. The preparation method of the long-acting cloxacillin benzathine breast injectant has the advantages that active ingredients of the beewax are effectively reserved and are processed into microcapsules, so that the contact area between the beewax and the breast tissues is increased, and the medical effect of the beewax can be fully played.

Description

technical field [0001] The invention belongs to the technical field of benzathine cloxacillin breast injection, in particular to a long-acting benzathine cloxacillin breast injection and a preparation method thereof. Background technique [0002] Dairy cows are modernized and the dry period is 60 days. The dry period is the best treatment period for mastitis and an important stage to prevent infection. During the dry period, antibiotics are usually injected into the breast chamber once. How to maintain the effective antibacterial concentration of intramammary antibiotics for a longer period of time and repair breast tissue damage up to 300 days during lactation is the focus of research on topical administration of intramammary drugs during dry lactation. [0003] Through clinical application, it was found that the effective antibacterial concentration of traditional medicine was only 21 days, and after the application of traditional medicine, the scar tissue infiltrated, wi...

AI Technical Summary

Problems solved by technology

[0003] Through clinical application, it was found that the effective antibacterial concentration of traditional medicine was only 21 days, and after the application of traditional medicine, the scar tissue was infiltrated, with unclear boundaries, poor tissue elasticity, regional inflammatory infiltration, and poor recovery of papillary smooth muscle

Images