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A drug-loading method for a drug-eluting balloon catheter

A balloon catheter and drug technology, applied in the field of medical devices, can solve problems such as infirmity, difficulty in quick release, easy to fall off, etc., and achieve the effect of uniform drug coating and rapid and stable drug release

Active Publication Date: 2016-07-06
LIAONING YINYI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned drug loading methods have the problems of uneven drug loading, looseness, easy fall off, and difficulty in rapid release. In order to improve the performance of drug balloons, it is necessary to seek a breakthrough in the combination of the balloon surface and the drug coating.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A drug-loading method for a drug-eluting balloon catheter, comprising the following steps:

[0024] ① Swell the balloon first: put the balloon in the solution and immerse it for 1 hour to make it swell. The solutions used for balloon swelling were methyl formate, ethyl acetate, ethyl formate, methyl acetate, propyl formate, methyl propionate, ethyl propionate, phenyl acetate, octyl acrylate and benzene Any one of methyl formate, or a mixture of two or more of them.

[0025] ② Prepare a mixed solution containing therapeutic drugs, additives, and solvents; place the swollen balloon on a vacuum spraying device, apply the mixed solution on the surface of the balloon using vacuum spraying technology, and let it dry naturally for 10 minutes. in:

[0026] The weight-number ratio of solvent, therapeutic drug and additive in the mixed liquid is 10-90:0.5-30:5-60.

[0027] The therapeutic drug is any one of paclitaxel, rapamycin and derivatives of the two drugs, or a mixture o...

Embodiment 2

[0034] The difference between this embodiment and embodiment 1 is:

[0035] The solution used for swelling the balloon in step ① is methyl acetate, and the immersion time for swelling is 30 minutes.

[0036] The solvent of the mixed solution prepared in step ② is acetonitrile aqueous solution, the fat-soluble drug is rapamycin, the additive is acrylic acid, and the natural air-drying time is 30 minutes. The mass concentration of acetonitrile aqueous solution is 90%.

[0037] The weight-number ratio of the acetonitrile aqueous solution, rapamycin, and acrylic acid is 90:0.5:5.

Embodiment 3

[0039] The difference between this embodiment and embodiment 1 is:

[0040] The solution used for swelling the balloon in step ① is ethyl acetate, and the immersion time for swelling is 1 hour.

[0041] The solvent of the mixed solution prepared in step ② is acetone aqueous solution, the fat-soluble drug is paclitaxel, the additive is UV glue, and the natural air-drying time is 25 minutes. The mass concentration of acetone aqueous solution is 60%.

[0042] The ratio of parts by weight of acetone aqueous solution, paclitaxel and UV glue is 50:15:30.

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Abstract

The invention relates to a drug-loading method for a drug-eluting balloon catheter, which comprises the following steps: ① Swelling the balloon first, and the swelling treatment time is 0.5h-3h; Spray the mixture of solvent and solvent on the surface of the swollen balloon, and let it dry naturally for 10-30 minutes. The weight-number ratio of solvent, therapeutic drug and additive in the mixed liquid is 10-90:0.5-30:5-60. Step ① The solution used for swelling the balloon is methyl formate, ethyl acetate, ethyl formate, methyl acetate, propyl formate, methyl propionate, ethyl propionate, phenyl acetate, octyl acrylate and any one of methyl benzoate, or a mixture of two or more of them. The drug-loading method of the drug-eluting balloon catheter of the invention can make the drug coating uniform and firm, and the drug release is rapid and stable.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug-loading method for a drug-eluting balloon catheter used in angioplasty. Background technique [0002] Since the first clinical application of percutaneous transluminal coronary angioplasty by Gruntzig in 1977, intravascular restenosis has been the main focus of debate in the treatment of PTCA. The application of drug-eluting stents has effectively solved this problem and has become another milestone in the history of percutaneous coronary intervention. However, in-stent restenosis caused by drug-eluting stents is extremely difficult to treat. If drug-eluting stents are inserted again, the probability of secondary restenosis is as high as 43%, and patients treated with drug-eluting stents need to take longer Dual antiplatelet drugs can prevent stent thrombosis; in addition, in special lesions such as small-diameter vascular lesions, long vascular lesions, and bifurcation vas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/16
Inventor 董何彦徐立霞卢春兰杜旭东杨刚
Owner LIAONING YINYI BIOTECH CO LTD
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