Nanosilicon dioxide/ferroferric oxide shell-core particle surface modifying method and magnetic nano material

Abstract

The invention relates to a 'nanosilicon dioxide / ferroferric oxide shell-core particle surface modifying method and a magnetic nano material' and belongs to the technical field of medicines. A microemulsion method is adopted, ferroferric oxide superparamagnetic nanoparticles with the particle size of about 15nm are added in a system of a surfactant NP-5 and cyclohexane, TEOS (Tetraethyl Orthosilicate) is introduced into a system of 30% ammonia water, so that silicon dioxide-coated ferroferric oxide superparamagnetic nanoparticles are formed, then amination is carried out on the silicon dioxide-coated ferroferric oxide superparamagnetic nanoparticles, and near infrared functional groups and polyethylene glycol sulfydryl functional groups are introduced under the action of covalence. The nanosilicon dioxide / ferroferric oxide shell-core particle surface modifying method comprises preparation of the nanosilicon dioxide / ferroferric oxide shell-core particles, amination on the near infrared functional groups on the surface of magnetic silicon dioxide pellets and polyethylene glycol sulfydrylation; the magnetic nano material prepared by adopting the method provided by the invention can be used for multimode imaging according to combination of molecular chemical substances different in size, proteins, short peptides, antibodies and radioactive elements, and diagnosis, treatment and monitoring on diseases are realized.

Description

Technical field [0001] The invention belongs to the field of material synthesis and application, and relates to a preparation method of a multifunctional nano material for molecular imaging, in particular to a preparation method of surface-modified nano-silica / ferroferric oxide shell core particles. Background technique [0002] Multi-modal molecular imaging technology is a multi-functional imaging technology developed on the basis of a single imaging technology that uses targeting groups such as small molecule chemicals, short peptides, proteins, antibodies, and macromolecules as functional groups. With the considerable progress made in nanotechnology in the past few decades, multimodal molecular imaging technology has also developed together. The superparamagnetic nanomaterials of nanometer ferroferric oxide that can be used for nuclear magnetic resonance imaging have been widely used in biomedicine, biological separation, magnetic fluid, photocatalysis, etc., and become a rese...

AI Technical Summary

Problems solved by technology

Ferroferric oxide nanoparticles are a popular magnetic material. However, due to the large surface area and high surface energy of the nanoparticles themselves, and the influence of the dipole interaction between the magnetic particles, it is relatively difficult to Non-magnetic nanoparticles are more likely to agglomerate and settle in the dispersion

Conventional solid silica-coated ferric oxide has no targeting and stable properties, making it difficult to carry out further functionalization reactions

Images