Biomimetic peritoneum for abdominal cavity open treatment and repairing, and preparation method thereof

Abstract

The invention relates to a biomimetic peritoneum for abdominal cavity open treatment and repairing, and a preparation method thereof. The biomimetic peritoneum comprises hydrogel, polylactic acid-glycolic acid micro beads, which are carried on the hydrogel, and a nano fiber membrane that covers the hydrogel and the polylactic acid-glycolic acid micro beads. The polylactic acid-glycolic acid micro beads carried by the hydrogel are the origin of growth factors required by the wound healing. A layer of nano fiber membrane is covered on the micro beads to form a two-layer membrane so as to construct an artificial biomimetic peritoneum, which can be applied to abdominal cavity open wound repairing. The biomimetic peritoneum can protect the intestinal canals, can also be used a carrier for releasing micro beads, organically integrates the functions of wound protection and drug release, and promotes the wound healing. The mimetic peritoneum probably promotes the healing process by participating in the formation of newborn tissues through differentiation or secreting cell factors to promote the formation of newborn tissues through paracrine. The artificial peritoneum and the micro beads generate a synergetic effect, can directly participate in the regeneration of damage tissue, moreover, can trigger the self regeneration and repairing mechanism of athletes, and finally achieve the rapid repairing of abdominal cavity open wound.

Description

technical field [0001] The invention relates to the technical field of open treatment and repair of the abdominal cavity, in particular to a bionic peritoneum for open treatment and repair of the abdominal cavity and a preparation method thereof. Background technique [0002] The repair of open wounds in the abdominal cavity is one of the important issues of wound repair. Trauma, infection and major abdominal surgery may lead to relative and absolute defects of the abdominal wall, which in turn may cause intestinal exposure and intestinal rupture, resulting in extremely high mortality and disability rates , Severe intra-abdominal infection is a common complication of abdominal trauma, gastrointestinal perforation, and severe pancreatitis. According to research at home and abroad, the treatment of abdominal infection is divided into the following stages: in the 1930s, surgical treatment reduced the mortality rate of patients with abdominal infection from 90% to about 50%; us...

AI Technical Summary

Problems solved by technology

In the early years, various patches were mainly used, such as polyester cloth, polypropylene mesh, absorbable mesh, decellularized human skin or pig skin, but the common feature of these patches is that the intestinal wall is gradually worn away, resulting in rupture of the intestinal tube

Although the addition of epidermal growth factor or the use of vacuum negative pressure suction technology can promote the growth of granulation tissue between intestinal tubes to a certain extent, it cannot restore normal intestinal microcirculatory blood flow, and eventually still leads to intestinal rupture and delayed wound healing.

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