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An imaging method for MRI contrast enhancement

An imaging method and contrast technology, applied in the field of magnetic resonance imaging and medical imaging, can solve problems such as adverse allergic reactions, and achieve the effect of solving the problem of excessive scanning time

Active Publication Date: 2016-06-15
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Problems solved by technology

However, this imaging enhancement method has certain safety issues. For example, although gadolinium contrast agents for magnetic resonance imaging have been proven to be safer in clinical use compared with iodine contrast agents for X-ray imaging or CT imaging, There are still 0.03-0.1% adverse allergic reactions

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  • An imaging method for MRI contrast enhancement
  • An imaging method for MRI contrast enhancement
  • An imaging method for MRI contrast enhancement

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Embodiment Construction

[0031] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0032] refer to figure 1 and figure 2 As shown, the specific steps are:

[0033] Step 1: Fix the two kinds of biological tissue samples in the central detection area of ​​the magnetic resonance imager, and measure the T 1 and T 2 relaxation time;

[0034] Step 2: At the same time when layer selection gradient 2 is turned on, the optimized inversion pulse 11 and the 90° excitation pulse 12 are sequentially applied to the biological tissue sample; the optimized inversion pulse 11 is a key component of the present invention, and numerical optimization based on gradient ascent can be used The method is obtained, and the specific description is as follows: Based on the T of different tissues obtained in step 1 1 and T 2 For relaxation time, the α-β model of the uncoupled two-spin system is established, which is characterized in tha...

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Abstract

The invention discloses an imaging method for MRI contrast enhancement, which uses an optimized inversion pulse to replace the inversion pulse and its recovery delay time of the conventional inversion recovery sequence in magnetic resonance imaging. Under the precise control of the optimized pulse, different The spin of the tissue will evolve towards the trend of maximizing the longitudinal magnetic moment difference, and the maximum longitudinal magnetic moment difference will be obtained at the end of the pulse; on this basis, applying a 90° excitation readout pulse will maximize the magnetic moment difference between tissues Turn over to the transverse plane, collect gradient echo signals to form k-space data, and use the improved phase-sensitive image reconstruction method to finally achieve the purpose of enhancing the contrast between tissues. The invention solves the problem that the scanning time of the conventional inversion recovery sequence is too long, fully utilizes the advantages of the flexibility of the optimized pulse waveform and the flexibility of the phase-sensitive image reconstruction method, avoids the use of expensive magnetic resonance contrast agents, and has excellent performance and cost. Outperforms current MRI contrast enhancement methods.

Description

technical field [0001] The invention relates to the field of medical imaging, in particular to the field of magnetic resonance imaging, in particular to an imaging method for MRI contrast enhancement. Background technique [0002] Magnetic resonance imaging (MRI) has developed into a very powerful medical diagnostic method, which is especially suitable for the diagnosis and detection of brain tissue, nervous system and human soft tissue. In magnetic resonance imaging, pulse sequences play a central role in manipulating the magnetic moments of atomic spins to generate desired magnetic resonance signals. The inversion recovery (IR) sequence is a commonly used traditional pulse sequence, which consists of a 180° inversion pulse, a certain delay time and a 90° excitation pulse to obtain T 1 Weighted imaging. Due to its simple structure, traditional IR sequences are widely used clinically, especially in pediatrics. However, the above-mentioned traditional pulse sequences are a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/055
Inventor 常严魏达秀杨晓冬
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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