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Application of phloretin in preparation of medicine for preventing and/or treating diabetes

Technology of a diabetes drug, phloretin, applied in the field of medicine

Inactive Publication Date: 2014-11-19
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are dozens of drugs to treat diabetes, it has not been able to change the status quo of the sixth cause of death in developed countries

Method used

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  • Application of phloretin in preparation of medicine for preventing and/or treating diabetes
  • Application of phloretin in preparation of medicine for preventing and/or treating diabetes
  • Application of phloretin in preparation of medicine for preventing and/or treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The following are some pharmacodynamic tests and results of phloretin anti-diabetes.

[0015] 1 experimental animal

[0016] 100 SPF-grade healthy kkay mice, weighing 18-22 g, provided by Chengdu Dashuo Biotechnology Co., Ltd.; 20 clean-grade healthy C57BL / 6J mice, weighing 18-22 g, provided by the Experimental Animal Center of Fourth Military Medical University Provided; all experimental animals were used for experiments after adaptive feeding for 3 days.

[0017] 2 Animal modeling methods

[0018] The kkay mice were fed with common feed for 1 week in a sterile environment, and the blood sugar was measured to meet the diabetes standard, and a high-fat diet was started to maintain a high blood sugar state.

[0019] 3 Grouping and handling of animals

[0020] The hyperglycemic kkay mice were completely randomly divided into 5 groups, namely: the control group, the phloretin 5mg / kg group, the 10mg / kg group, the 20mg / kg group and the glimepiride group. Dosage of drugs;...

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Abstract

The invention relates to application of phloretin in preparation of medicine for preventing and treating diabetes. A spontaneous diabetes animal model kkay mouse for transferring Ay genes is introduced, the influence of phloretin on related indexes such as blood glucose and blood fat of diabetes in the mouse is researched, an antidiabetic effect of the phloretin is proved, and a basis is provided for applying the phloretin to the medicine for preventing and treating diabetes.

Description

technical field [0001] The invention relates to the use of phloretin in the preparation of drugs for preventing and / or treating diabetes, and belongs to the technical field of medicine. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia due to defects in insulin secretion and / or insulin action. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. Severe cases can cause acute complications such as dehydration, electrolyte disturbance and acid-base imbalance, ketoacidosis and hyperosmolar coma. The symptoms of diabetes can be divided into two categories: one category is related to metabolic disorders, especially the "three excesses and one deficiency" related to hyperglycemia, and the other category is the manifestations of various acute and chronic complica...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P3/10
Inventor 刘雪英马李杰王庆伟段鸿涛王力彬弥乐沈歆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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