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Dural/spinal dural biological patch material, preparation method and application thereof

A technology of biological patch and meninges, which is applied in the field of tissue engineering medical biomaterials, can solve the problems of excessive degradation and unfavorable repair, improve safety and effectiveness, and reduce the risk of side effects, complications and side effects The risk reduction effect of

Active Publication Date: 2014-11-05
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] For this reason, the technical problem to be solved by the present invention is that in the prior art, the dural / spinal replacement material degrades too fast or too slow after being implanted into the human body, which is not conducive to repairing the dura / spinal defect, and then provides a Dural / spinal biopatch material suitable for the degradation requirements of dura / spinal defect repair, and discloses its preparation method and application

Method used

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  • Dural/spinal dural biological patch material, preparation method and application thereof
  • Dural/spinal dural biological patch material, preparation method and application thereof
  • Dural/spinal dural biological patch material, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0041] The preparation method of the dura / spinal biopatch described in this implementation comprises the steps:

[0042] (1) Take out the membrane tissue of cows less than 6 months old as raw materials, clean them, remove unsuitable parts for processing, and set aside;

[0043] (2) Take the above-mentioned cleaned membrane tissue and add it to a TritonX_100 solution with a mass concentration of 0.1 wt%, soak it, shake it overnight, and control the solution temperature to 0°C;

[0044] (3) Take the membrane tissue soaked in the above steps and add it to a sodium hydroxide solution with a concentration of 5 mol / L for 2 hours, and control the temperature of the solution to 15°C;

[0045] (4) Take the membrane tissue soaked in the above steps and add it into a hydrogen peroxide solution with a mass concentration of 1 wt% for soaking for 1 hour;

[0046] (5) Take the membrane tissue soaked in the above steps and add it to a concentration of 1 wt% glycerol glycidyl ether and soak f...

Embodiment 2

[0050] The preparation method of the dura / spinal biopatch described in this implementation comprises the steps:

[0051] (1) take out the membrane tissue of the cow under 6 months old as raw material, clean it, and set it aside;

[0052] (2) Take the above-mentioned cleaned membrane tissue and add it into a Tween80 solution with a mass concentration of 5 wt%, soak it, shake it overnight, and control the solution temperature to 25°C;

[0053] (3) Take the membrane tissue soaked in the above steps and add it to a potassium hydroxide solution with a concentration of 0.1mol / L for 4 hours, and control the temperature of the solution to 5°C;

[0054] (4) Take the membrane tissue soaked in the above steps and add it into a peroxide solution with a mass concentration of 5wt% for soaking for 5 hours;

[0055] (5) Take the membrane tissue soaked in the above steps and add the mass concentration to be 1wt% ethylene glycol glycidyl ether and soak for 15 hours;

[0056] (6) Then take the...

Embodiment 3

[0059] The preparation method of the dura / spinal biopatch described in this implementation comprises the steps:

[0060] (1) take out the membrane tissue of the cow under 6 months old as raw material, clean it, and set it aside;

[0061] (2) Take the above-mentioned cleaned membrane tissue and add it into a solution containing TritonX_100 and Tween40 with a mass concentration of 2wt% for soaking, shake overnight, and control the solution temperature to 8°C;

[0062] (3) Take the membrane tissue soaked in the above steps and add it to a sodium hydroxide solution with a concentration of 1mol / L to soak for 2 hours, and control the solution temperature to 8°C;

[0063] (4) Take the membrane tissue soaked in the above steps and add it into a peroxide solution with a mass concentration of 2wt% for soaking for 3 hours;

[0064] (5) Take the membrane tissue soaked in the above steps and add it into a mixed cross-linking agent containing glycerol glycidyl ether and ethylene glycol gly...

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Abstract

The invention provides a dural / spinal dural biological patch material, a preparation method and application thereof. The obtained biological patch material is especially suitable for repair of dural / spinal dural defect, can maintain stable and non-degradable within 6 months-2 years after being implanted into the human body or animals, and can degrade gradually after more than 2 years. While ensuring certain mechanical properties and liquid seepage resistance, the biological patch material also has biocompatibility, has greatly reduced risks of postoperative complications and side effects, and meets the special requirements for dural / spinal dural defect repair materials.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering medical biomaterials, in particular to a dura / spinal biopatch material and its preparation method and application. Background technique [0002] The dura mater and dura mater are important functional membrane tissues between the brain and skull, spine and spinal cord respectively, and have the same biological characteristics and functions. The dura mater is attached to the inner surface of the cranial cavity, loosely connected with the calvaria, and tightly combined with the skull base; the dura mater extends outward at the cranium of the cranial nerve, migrates and combines with the capsule of the nerve, and extends downward to the dura mater around the foramen magnum . The function and structure of the dura mater and the dura mater are consistent, the dura mater is used to protect the brain tissue, and the dura mater is used to protect the spinal cord tissue. [0003] Trauma, tumor,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12A61L27/36A61L31/00
Inventor 孙先昌徐秀董佳桓郭松郭刚王彬
Owner YANTAI ZHENGHAI BIO TECH
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