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A kind of biocompatible bile acid chelating agent and its preparation method and application

A technology of biocompatibility and chelating agent, applied in the fields of gel synthesis and medical polymer synthesis, can solve the problems of container bursting, unfavorable biological discharge, and difficult degradation of bile acid chelating agent.

Active Publication Date: 2016-08-24
山东慕尔斯新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The vapor of epichlorohydrin and air will form an explosive mixture, which will easily lead to safety accidents such as container bursting
In addition, commercially available bile acid sequestrants are difficult to degrade in the organism, which is not conducive to the excretion of the organism

Method used

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  • A kind of biocompatible bile acid chelating agent and its preparation method and application
  • A kind of biocompatible bile acid chelating agent and its preparation method and application
  • A kind of biocompatible bile acid chelating agent and its preparation method and application

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Embodiment Construction

[0006] Technical scheme of the present invention is as follows:

[0007] A biocompatible bile acid sequestrant has the following structural formula:

[0008]

[0009] The preparation method of the above-mentioned biocompatible bile acid sequestrant, the steps are as follows:

[0010] (1) Add anhydrous sodium carbonate to allylamine, the molar ratio of anhydrous sodium carbonate to allylamine is (1.2~1.5): 1, after stirring, drip Add hexyl bromide, the molar ratio of allylamine to hexane bromide is (10-30):1, in N 2 React under protection for 5-10 hours, and obtain N-hexylallylamine through filtration, washing, extraction, and vacuum distillation;

[0011] Under ice-water bath conditions, the prepared N-hexylallylamine was added dropwise to hydrochloric acid, and the reaction solution was concentrated, recrystallized, and vacuum-dried to obtain N-hexylallylamine hydrochloride;

[0012] (2) N-hexylallylamine hydrochloride prepared in step (1) is formulated into N-hexylally...

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Abstract

The invention relates to a biocompatible bile acid sequestrant and its preparation method and application. The preparation method steps are as follows: (1) N-hexylallylamine is added dropwise in hydrochloric acid to obtain N-hexylallylamine hydrochloride; (2) N-hexylallylamine hydrochloride aqueous solution and Allylamine hydrochloride aqueous solution is mixed uniformly, adding initiator, polymerization reaction, obtains polymer precursor; (3) methyl-α-D-glucopyranoside is dissolved in deionized water, adds oxidizing agent, avoids photoreaction to prepare a dialdehyde crosslinking agent; (4) adding a dialdehyde crosslinking agent solution to the polymer precursor aqueous solution, stirring and mixing, and standing at room temperature for reaction to prepare a biocompatible bile acid chelating agent. In the preparation method of the present invention, the cross-linking agent only uses the biocompatible dialdehyde cross-linking agent obtained by oxidizing glycosides. In addition, no other toxic cross-linking agents are used, which has good biocompatibility and reduces risks of in vivo application.

Description

technical field [0001] The invention relates to a biocompatible bile acid sequestrant and its preparation method and application, belonging to the technical fields of gel synthesis and medical polymer synthesis. Background technique [0002] With the improvement of people's living standards, hyperlipidemia has increasingly become one of the main diseases threatening human health, and the treatment of hyperlipidemia has also become a major urgent issue facing medicine. Among them, bile acid sequestrants are a class of effective drugs. The mechanism of action of this type of drug is to block the reabsorption of bile acid anions in the small intestine, break the enterohepatic circulation of bile acid, and promote the conversion of low-density lipoprotein-cholesterol in the blood to bile acid in liver cells, so as to achieve the purpose of lowering blood lipids . [0003] The bile acid chelating agent is usually a polymer chelating resin obtained by chemically crosslinking a c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08F226/02A61P3/06A61K31/785
Inventor 谭业邦王鑫王晓藜
Owner 山东慕尔斯新材料科技有限公司
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