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Method suitable for simultaneously detecting 9 N-nitrosamines in food contact rubber products

A technology for food contact and rubber products, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve problems such as the inability to meet the requirements of the N-nitrosamine limit

Inactive Publication Date: 2014-10-01
THE INSPECTION & QUARANTINE TECH CENT ZHEJIANG ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Obviously, my country's current national standards cannot meet the international requirements for the limit of N-nitrosamines in food contact rubber products

Method used

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  • Method suitable for simultaneously detecting 9 N-nitrosamines in food contact rubber products
  • Method suitable for simultaneously detecting 9 N-nitrosamines in food contact rubber products
  • Method suitable for simultaneously detecting 9 N-nitrosamines in food contact rubber products

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Experimental program
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Embodiment 1

[0122] Embodiment 1. A simultaneous detection method applicable to 9 kinds of N-nitrosamines in food contact rubber products, comprising the following steps:

[0123] 1), preparation of artificial simulated saliva:

[0124] Artificial simulated saliva (g / L) formula refers to GB / T18886-2002: lactic acid (CH 3 CH(OH)COOH) 3.0g; Urea (H 2 NCONH 2 ) 0.2g; Sodium chloride (NaCl) 4.5g; Potassium chloride (KCl) 0.3g; Sodium sulfate (NaCl) 2 SO 4 ) 0.3g; ammonium chloride 0.4g, dilute to 1L with distilled water;

[0125] 2) Establishment of migration system

[0126] Take the sample to be tested, cut it into small pieces of about 10mm×10mm, mix well, and use it as a sample.

[0127] Weigh 10.0g sample, accurate to 0.01g, place it in a stoppered Erlenmeyer flask, add 60.0mL artificial saliva to immerse the sample, and let it stand in a water bath at 37°C for 36 hours; filter to obtain a migration extract;

[0128] 3), prepare the sample solution to be tested

[0129] (1) Take al...

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Abstract

The invention discloses a method suitable for simultaneously detecting 9 N-nitrosamines in food contact rubber products. The method comprises the following steps: utilizing a sample to be tested to establish a migration system to obtain a migration extract; utilizing the migration extract to prepare a sample solution to be tested to obtain a supernatant / filtrate; preparing 9 N-nitrosamines into a standard solution to further prepare a standard working solution with the gradient of 0.01-0.40 [mu]g / mL; injecting the gradient standard solution and the supernatant / filtrate into a liquid Chromatogram-tandem mass spectrograph, and testing the cation multi-reaction monitoring model to finally obtain the respective contents of 9 N-nitrosamines in the sample to be tested. The 9 N-nitrosamines are N-Nitrosodimethylamine, N-Nitroso-ethyl methylamine, N-Nitrosomorpholine, N-Nitrosopiperidine, N-Nitrosopyrrolidine, N-Nitroso-diethylamine, N-Nitrosodibutylamine, N-Nitrosodi-n-propylamine and N-Nitroso-diphenylamine.

Description

technical field [0001] The invention relates to a detection method suitable for N-nitrosamine in food contact rubber products. Background technique [0002] Rubber products are widely used in various fields such as national defense, industry and agriculture, and service industries, and are often used in people's daily life. From pressure cooker gaskets in the food field, sealing gaskets for various glass bottle caps, suction rubber tubes for the production of various liquid condiments, etc., to latex gloves, hot water bottles, club covers, sports balls, etc. involved in daily necessities Plastic track, etc., condoms in family planning products, etc., and many children's appliances such as baby pacifiers, suction nozzles, rubber balls, armrests in strollers, rubber balls, balloons, Barbie dolls, erasers, plasticine, etc. Rubber products abound . [0003] In 1982, the U.S. Consumer Product Safety Commission revealed that baby rubber pacifiers and soothers on the market may c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 吴刚赵珊红王力君张明誉阮毅
Owner THE INSPECTION & QUARANTINE TECH CENT ZHEJIANG ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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