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Compound skin mucous membrane disinfectant, preparation method and application thereof

A disinfectant and compound technology, which is applied in the field of compound skin and mucous membrane disinfectant, can solve the problems of difficult to obtain effect and difficult to kill microorganisms, and achieve the effect of convenient use, fast action and reliable effect

Active Publication Date: 2014-09-24
INST OF PLA FOR DISEASE CONTROL & PREVENTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These skin and mucous membrane disinfectants can generally achieve the effect of killing bacteria within 5 minutes, but it is difficult for microorganisms with strong resistance (such as disinfection index virus-poliomyelitis virus) to achieve the killing effect, even if the action time is prolonged Difficult to achieve results

Method used

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  • Compound skin mucous membrane disinfectant, preparation method and application thereof
  • Compound skin mucous membrane disinfectant, preparation method and application thereof
  • Compound skin mucous membrane disinfectant, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, preparation compound skin mucous membrane disinfectant

[0040] The composition of the disinfectant is as follows:

[0041]

[0042] Preparation: First weigh polyethylene glycol and heat it until completely melted, then cool it below 50°C, slowly add dissolved iodine and potassium iodide while stirring, after stirring for 1 hour, add didecyldimethylammonium chloride, benzene Zalkonium chloride and polyethylene glycol 6000, and then add deionized water to prepare the total amount.

Embodiment 2

[0043] The evaluation test of the compound skin mucous membrane disinfectant that embodiment 2, embodiment 1 make

[0044] The disinfectant described in Example 1 of the present invention has carried out microbial killing effect test, field test, and safety evaluation according to "Disinfection Technical Specification" (2002 edition).

[0045] Test one, the experimental research that the disinfectant of the embodiment of the present invention 1 kills virus

[0046] The experimental virus strains and their sensitive cells used were poliovirus type I (PV-I) vaccine strain and Vero-E6 cells.

[0047] Neutralizer used: phosphate buffer saline (PBS, 0.03mol / L, pH7.2) containing 5.0g / L sodium thiosulfate, 30.0g / L Tween-80 and 3.0g / L lecithin;

[0048] Organic Interfering Substance (BSA): 3.0% Bovine Serum Albumin;

[0049] Cell digestion solution: 1:250 trypsin (1.0g trypsin, 25ml 0.02% EDTA disodium and 225ml D-Hanks solution);

[0050] Cell maintenance medium: 1640 dry powder m...

Embodiment 3

[0123] Embodiment 3, preparation compound skin mucous membrane disinfectant

[0124] The composition of the disinfectant is as follows:

[0125]

[0126] Wherein, the quaternary ammonium salt is: alkyl dimethyl benzyl ammonium chloride ((trade name: 3350; C1450%, C1240%, C1610%), octyl-decyl-dimethyl ammonium chloride, di Octyl-dimethylammonium chloride and didecyldimethylammonium chloride compound (trade name: 208M) prepared in a mass ratio of 40:30:12:18.

[0127] The preparation method is the same as in Example 1.

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Abstract

The invention provides a compound disinfectant and a preparation method, the compound disinfectant comprises the following components: 0.5-10.0g / L of iodine, 0.5-2.0g / L of quaternary ammonium salt, 0.2-3.0g / L of potassium iodide, 10g / L-30g / L of polyethylene glycol, 2.5-25.0g / L of nonionic surfactant and the balance of deionized water. The quaternary ammonium salt preferably selects a mixture of single chain quaternary ammonium salt and double-chain quaternary ammonium salt. The invention also provides an application of the compound disinfectant for killing virus and bacteria on skin, mucous membrane, wound, hand and object surface. While in use, the compound skin mucous membrane disinfectant has no irritation on skin mucous membrane, no toxic and side effect, no anaphylactic reaction, convenient usage, wide application scope and rapid effect, and has microbe killing effect. The compound skin mucous membrane disinfectant has reliable effect for various pathogenic microorganism, can kill envelope-free virus in 3 minutes, and is an important means for preventing and controlling various infectious diseases.

Description

technical field [0001] The invention relates to a compound skin and mucous membrane disinfectant and its preparation method and application. Background technique [0002] Viruses have continued to feature prominently among the human pathogenic microorganisms that have been identified over the past few decades. More than 70% of human infectious diseases are caused by viruses, that is, viral infectious diseases. Even minor outbreaks of viral infectious diseases can have serious consequences for troops and civilians. At present, infectious diseases such as smallpox and polio have been eradicated by effective vaccines; hepatitis A and B have been brought under control; measles was originally scheduled to be completely eliminated in 2012, but the incidence of measles is still high; new and more serious infections Diseases, such as AIDS, mad cow disease, Creutzfeldt-Jakob disease, SARS, hand, foot and mouth disease (listed as a legal infectious disease in 2007), avian influenza,...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61P31/02A61P31/04A61P31/10A61P31/12A61P17/00A01N59/12A01P1/00A01P3/00A61K31/14
CPCY02A50/30
Inventor 帖金凤张文福苏裕心袁国刚张哲王长德
Owner INST OF PLA FOR DISEASE CONTROL & PREVENTION
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