Chitosan gel and preparation method thereof

Abstract

The invention relates to the technical field of biogel, specifically to chitosan gel and a preparation method thereof. The gel comprises the following raw materials by weight: 0.5 to 4.5% of modified chitosan, 0.5 to 15% of glycerin, 0.5 to 5% of alum, 0.01 to 0.13% of menthol, 0.2 to 5% of carboxymethylcellulose sodium and 0.2 to 1% of carbomer. The gel is a drug delivery system with a controlled-release function, can improve availability of effective substances, can be tightly applied on an uneven wound without adhesion, avoids secondary harm, has good biocompatibility and strong antibiosis and antiphlogosis effects, incurs no local irritation and no adverse reaction, is capable of rapidly promoting wound healing and effectively treating hemorrhoids, enables hemorrhoids not to recur and is applicable to improvement of symptoms like hemorrhoidal bleeding, hyperemia and oedema of the mucous membranes of hemorrhoids, bearing-down swelling of the anus, constipation, prolapsus of hemorrhoid nuclear and the like caused by internal hemorrhoids, external piles and mixed hemorrhoids and control, nursing and the like after anal fissure and anorectal operations.

Description

technical field [0001] The invention relates to the technical field of biogel, in particular to a chitosan gel and a preparation method thereof. Background technique [0002] Hemorrhoids is a common disease located in the anus. It can occur at any age, but with age, the incidence rate gradually increases. It is known as "nine hemorrhoids in ten men" and "ten hemorrhoids in ten women". Hemorrhoids are usually incurable for a long time , Bring great inconvenience to normal life and work. [0003] The traditional treatment of hemorrhoids adopts injection therapy. The commonly used injections mainly include hardening atrophy agent and hemorrhoid necrosis shedding agent. The former is easy to relapse in the treatment of hemorrhoids, while the latter has more side effects. It is painful and does not require hospitalization, but it can only be applied to smaller hemorrhoids, and cannot treat fourth-degree hemorrhoids; surgical resection of hemorrhoids, although the treatment is co...

AI Technical Summary

Problems solved by technology

[0002] Hemorrhoids is a common disease located in the anus. It can occur at any age, but with age, the incidence rate gradually increases. It is known as "nine hemorrhoids in ten men" and "ten hemorrhoids in ten women". Hemorrhoids are usually incurable for a long time , bringing great inconvenience to normal life and work

[0003] The traditional treatment of hemorrhoids adopts injection therapy. The commonly used injections mainly include hardening atrophy agent and hemorrhoid necrosis shedding agent. The former is easy to relapse in the treatment of hemorrhoids, while the latter has more side effects. Pain, no need to be hospitalized, but it can only be applied to smaller hemorrhoids, and cannot treat fourth-degree hemorrhoids; surgical resection of hemorrhoids, although the treatment is complete and not easy to relapse, there are disadvantages such as postoperative pain, hospitalization, and recuperation

[0004] At present, various lotions, ointments, suppositories, etc. can achieve a certain therapeutic effect on patients with initial hemorrhoids, but the therapeutic effect is poor and cannot effectively treat hemorrhoids, and hemorrhoids are prone to relapse.