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Styrene system ion exchange resin as well as preparation method and application thereof

An ion-exchange resin and styrene-based technology, applied in chemical instruments and methods, other chemical processes, blood circulation treatment, etc., can solve the problems of nephrotoxicity, side effects, and high price of polymyxin B, and achieve adsorption The effect of remarkable effect and simple preparation method

Inactive Publication Date: 2014-08-13
李涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polymyxin B is expensive and has nephrotoxicity. If it falls off from the carrier and enters the human blood, it will have direct toxic and side effects

Method used

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  • Styrene system ion exchange resin as well as preparation method and application thereof
  • Styrene system ion exchange resin as well as preparation method and application thereof
  • Styrene system ion exchange resin as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0036] The preparation method of above-mentioned styrene-based ion-exchange resin, concrete preparation steps are as follows:

[0037] (1) Prepare cross-linked styrene-divinylbenzene copolymer by free radical suspension copolymerization of styrene monomer and divinylbenzene monomer:

[0038] 1. styrene 40g and divinylbenzene 10g mixture that contains initiator benzoyl peroxide 0.4g are suspended in the aqueous phase that contains dispersant, and described dispersant is polyvinyl alcohol or carboxyl-containing polymer;

[0039] ②Under stirring conditions, make most of the suspended droplets within the range of 30-70 mesh, and the organic phase (the state of a solution formed by mixing styrene and divinylbenzene) is dispersed into beads;

[0040] ③Heat to 95°C to decompose benzoyl peroxide (initiator) to initiate polymerization to obtain beaded styrene-divinylbenzene copolymer; add toluene, and remove toluene by distillation after polymerization to form a macroporous type Cross...

Embodiment 2

[0045] A kind of preparation example of styrene ion exchange resin

[0046] The preparation method of above-mentioned styrene-based ion-exchange resin, concrete preparation steps are as follows:

[0047] (1) Prepare cross-linked styrene-divinylbenzene copolymer by free radical suspension copolymerization of styrene monomer and divinylbenzene monomer:

[0048] 1. styrene 40g and divinylbenzene 10g mixture that contains initiator benzoyl peroxide 0.4g are suspended in the aqueous phase that contains dispersant, and described dispersant is polyvinyl alcohol or carboxyl-containing polymer;

[0049] ②Under stirring conditions, make most of the suspended droplets within the range of 30-70 mesh, and the organic phase disperses into beads;

[0050] ③Heating to 95°C to decompose benzoyl peroxide (initiator) to initiate polymerization to obtain beaded styrene-divinylbenzene copolymer;

[0051] ④ After the polymerization is completed, wash the polymer cross-linked polystyrene beads with ...

experiment example

[0055] 1. The experimental steps adopted for the realization of human in vitro experiments and animal model experiments are as follows:

[0056] (1) In vitro experiment on human body

[0057] Accurately measure 10 parts of the styrene-based ion-exchange resin described in Example 1, 1ml per part, mix the resin with the blood plasma of endotoxin-positive patients at a ratio of 1:10 (v / v), place in a 37°C constant temperature water bath and shake for 150min, according to the adsorption The plasma endotoxin and cytokine concentrations before and after were calculated to calculate the adsorption rate.

[0058] Adsorption rate L (%) = (C 0 -C) / C 0 ×100%

[0059] In the formula, C 0 and C are the concentrations before and after adsorption, respectively.

[0060] (2) Animal model experiments

[0061] The animal model of severe endotoxemia infection was prepared by bacterial infection (the rabbits used for the experiment were fed, and the model was prepared by injecting endotoxi...

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Abstract

The invention provides a styrene system ion exchange resin as well as a preparation method and application thereof. The styrene system ion exchange resin is prepared by taking styrene and toluylene as monomers and is a milk-white nontransparent spherical particle; the diameter is 0.05-1.20 mm; the density is as follows: the true wet density is 1.06-1.10 g / ml, and the apparent wet density is 0.65-0.75 g / ml; the strength (attrited sphericity) is more than or equal to 95%; the surface active group is -N+(CH3)2; the aperture is 80-100 nanometers; the porosity is 45%-22%; the pore volume is 0.75-0.84 ml / g; the specific area is 850-1000 m<2> / g; the full exchange capacity of dry resin is 3.7 mmol / g, and the full exchange capacity of wet resin is 1.1 mmol / g. The styrene system ion exchange resin provided by the invention is an effective cell factor adsorbing material, achieves outstanding adsorption effect on endotoxins and inflammatory factors which are contained in blood and can be applied to the aspect of resin hemoperfusion apparatus.

Description

technical field [0001] The invention relates to a copolymer material and its preparation method and application, in particular to a styrene-based ion exchange resin and its preparation method and application. Background technique [0002] Severe infection can cause a variety of human diseases, such as endotoxemia, which can lead to organ necrosis, irreversible shock and even death in severe cases, seriously endangering the health and life of patients. The treatment of severe infection is an important subject of medical clinical research. [0003] In recent years, some progress has been made in the treatment of severe infection by hemoperfusion (HP) at home and abroad. Researchers in Japan coated polymyxin B (Polymyxin B, PMB) on the inner wall of the hollow fiber of the blood filter to make a PMB blood fiber adsorption column (PMX-F, trade name Toraymyxin, Toray Industries Inc. Japan), The results of its clinical trials show that PMX-F can effectively treat severe infectio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F212/36C08F2/20C08F8/24C08F8/32C08J9/28B01J20/26B01J20/30A61M1/38
Inventor 李涛
Owner 李涛
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