Amphiphilic pillar [5] arene self-assembled vesicle and depolymerization reversibility and controllability control method thereof

Abstract

The invention discloses a synthesis method of low-polyethylene-glycol functional amphiphilic pillar [5] arene compound (AP5-glycol), wherein AP5-glycol is self-assembled in water to form a vesicle, and the vesicle can generate responsive depolymerization (the vesicle becomes small or gradually disappears) after being affected by external physical stimulation such as heating, ultrasonic treatment, violent stirring and the like and can be rapidly formed again after the external stimulation is stopped, i.e., the two processes including vesicle formation and vesicle depolymerization are reversible and controllable. Therefore, the vesicle has excellent thermodynamic reversibility and controllability. In addition, KPF6 and benzo-18-crown-6 can be respectively used as a switch for depolymerizing and forming a vesicle self-assembly again. The characteristics can ensure that the vesicle has outstanding recyclability in application such as drug release or transfer and the like.

Description

technical field [0001] The present invention relates to the synthesis of oligoethylene glycol-functionalized amphiphilic pillar [5] arene, its self-assembly to form vesicles and its depolymerization reversibility and controllability control method Background technique [0002] Supramolecular compounds such as crown ethers, cyclodextrins, cucurbits, calixarenes, etc., have attracted great attention of researchers due to their fascinating properties and wide range of applications. Supramolecular chemistry, which takes supramolecular compounds as the research object, is an important extension of the chemical research field. Up to now, the research content of supramolecular chemistry includes molecular recognition, molecular self-assembly, catalysis and selective bonding. The formation of functional supramolecular systems through molecular self-assembly is one of the goals of supramolecular chemistry. Therefore, molecular self-assembly plays the most important role in host-gues...

AI Technical Summary

Problems solved by technology

However, the research on the self-assembly application of pillararenes still has the following deficiencies: First, the species of amphiphilic pillar[5]arenes are very rare. The research on the self-assembly behavior of amphiphilic pillar[5]arenes in aqueous solution is still in its infancy, and the research on the self-assembly behavior of amphiphilic pillar[5]arenes in aqueous solution is especially rare. , medicine and other fields of application prospects

2. In aqueous media, the research and application of the self-assembly system of amphiphilic pillar aromatics is rarely reported at home and abroad

The research and application of the reversible process of the formation and depolymerization of self-assembly systems of amphiphilic pillararenes can be controlled by a simple method.

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