Composition for treating atherosclerosis

Abstract

The invention discloses a composition for treating atherosclerosis. The composition is characterized by comprising geranialdehyde used as an effective component, wherein the geranialdehyde is from lemon myrtle, litsea cubeba, cubeb litsea tree, lemon grass and lemon tea tree, wherein the concentration of the geranialdehyde is 1-51g / ml. The pharmaceutical composition containing the geranialdehyde has an unequal inhibition effect on hyperplasia of human aortic smooth muscle cells stimulated by lipopolysaccharide. Compared with the geranialdehyde and other flavonoid compounds, the composition has the best activity, can inhibit hyperplasia of human aortic smooth muscle cells caused by oxidized low-density lipoprotein, does not have toxicity on cells, and can inhibit inflammatory response.

Description

technical field [0001] The invention relates to a composition for preventing and treating atherosclerosis. Background technique [0002] Cardiovascular disease is a syndrome of the heart and blood vessels. Cardiovascular disease can be divided into coronary heart disease, cerebrovascular disease, peripheral arterial occlusive disease, rheumatic heart disease, congenital heart disease, deep vein thrombosis and pulmonary embolism. Coronary arteriosclerosis may cause angina, myocardial infarction or sudden death, cerebral or carotid arteriosclerosis may lead to renal hypertension or even uremia, and peripheral arteriosclerosis may lead to aneurysm or obliterative arteriosclerosis. Therefore, arteriosclerosis is inseparable from cardiovascular disease. [0003] Because the cause of atherosclerosis is hyperlipidemia or blood coagulation, such as lipopolysaccharide activated cytokine TNF-α, This in turn stimulates smooth muscle cell proliferation and increases the production ...

AI Technical Summary

Problems solved by technology

(1) Bile acid binding resin prevents the absorption of bile acid in the gastrointestinal tract, so as to increase the compensatory use of cholesterol in the liver to produce bile acid, and reduce the content of cholesterol in liver cells, but side effects such as gastrointestinal discomfort (diarrhea, constipation) may occur

(2) Fibrous acid derivatives reduce the concentration of triglycerides in the blood, which may cause side effects such as abdominal pain, diarrhea, nausea, vomiting, and increased liver function index

(3) Nicotinic acid derivatives can reduce the concentration of low-density lipoprotein, triglyceride, and cholesterol, and increase the concentration of high-density lipoprotein, but have gastrointestinal discomfort, high uric acid, gout, rash, liver function Side effects such as index increase, if taken for a long time may increase the chance of gallstones

(1) Vitamin K antagonists include Warfarin (former rodenticide), dicoumarol, etc., whose chemical structure is similar to vitamin K, and whose mechanism of action is to antagonize vitamin K-dependent blood coagulation factors II, VII, IX, Active reaction of X, but side effects such as hematuria, gastrointestinal tract and intracerebral hemorrhage will occur

(2) Heparin is composed of D-glucosamine, L-iduronic acid and D-glucuronic acid alternately, which first binds to the third anticoagulant factor, thereby accelerating the deactivation of thrombin, and then To achieve anticoagulant effect, it can also combine with various coagulation factors IIa, Xa, XIa, and XIIa to inactivate them, but may cause side effects such as bleeding, allergic reactions, and thrombocytopenia

(3) Direct thrombin inhibitors include hirudin and bivalirudin, etc., wherein hirudin is a protein with 65 amino acids from the leech salivary gland, which plays a key role in hemostasis and inhibition of thrombus formation, although Hirudin is the strongest natural thrombin inhibitor, but it is difficult to extract from leeches and must be prepared by recombinant biotechnology

Terutroban among blood coagulation lipid inhibitors can block platelet aggregation reaction and vasoconstriction caused by blood coagulation lipids, promote endothelial function and have anti-atherosclerosis effect, but it has hemorrhagic risk

[0010] The effect of thrombolytic agents is to activate cytoplasmin and promote fibrinolysis. It is suitable for the treatment of deep vein embolism, pulmonary embolism, acute myocardial infarction and acute arterial embolism, but it will cause bleeding and allergic reactions

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