Benzofuran compounds and their medicinal uses
A technology for benzofuran and compound, which is applied in the field of benzofuran compounds and their medicinal uses, can solve problems such as difficulty in controlling intestinal symptoms, and achieve the effects of inhibiting fat absorption, preventing catalytic decomposition, and being highly selective.
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Embodiment 1
[0056] Example 1: Preparation of 4-[2-(benzofuran-7 base)ethoxy]benzamide (Compound No. 01)
[0057] 1. Preparation of 7-(2-bromoethyl)benzofuran
[0058]Add 18.00g (0.13mol) of 7-hydroxybenzofuran, 22.68g (0.14mol) of 1,2-dibromoethane, 6.00g (0.04mol) of potassium iodide, and 49.63g (0.36mol) of potassium carbonate into the reaction flask. Acetone was used as solvent and heated to reflux for 3.5h. Suction filtration, rotary evaporation to remove acetone, add an appropriate amount of petroleum ether to dissolve, extract once with 5% NaOH aqueous solution, collect the organic layer and dry it with anhydrous magnesium sulfate. Filtrate, and remove petroleum ether by rotary evaporation to obtain a light yellow oil, add a small amount of petroleum ether to freeze, and a white solid precipitates out. Filter and dry to obtain 22.36g of white solid, yield 69.13%, mp: 72.7-74.5°C. GC-MS m / z: 239.9; 1 H-NMR (CDCl 3 )δ(ppm): 1.98(2H,m), 2.20(2H,m), 2.71(2H,t), 3.72(2H,t), 4.06(2H,...
Embodiment 2
[0065] Example 2: Preparation of N,N-dimethyl-4-[2-(benzofuran-7yl)ethoxy]benzamide (Compound No. 02)
[0066] According to the method of example 1, by 4-[3-(chroman-7-oxygen) propoxyl group] benzoic acid 0.66g (0.002mol), dimethylamine 0.09g (0.002mol), EDC0.42g (0.0022 mol), HOBt0.03g (0.0002mol), triethylamine 1.00g (0.01mol) to give 0.51g of white solid, yield 78.46%, mp: 118.4-119.2℃. LC-MS m / z: 326.1 ([M+H] + ),348.1([M+Na] + ),364.1([M+K] + ); 1 H-NMR (CDCl 3 )δ (ppm): 3.10 (6H, s), 4.28 (2H, m), 4.32 (2H, m), 6.52 (2H, d, J =8.4Hz),6.82(2H,d, J =7.5Hzt),6.98(2H,d, J =8.7Hz),7.08(2H,m),7.20(1H,d, J =7.8Hz),7.45(1H,d, J =8.4Hz),7.66(2H,d, J =8.7Hz); IR(KBr)υ / cm -1 : 3318, 2719, 1642, 1153, 1046, 1153, 1122, 1008, 831, 612.
Embodiment 3
[0067] Example 3: Preparation of N,N-diethyl-4-[2-(benzofuran-7yl)ethoxy]benzamide (Compound No. 03)
[0068] According to the method of example 1, by 4-[3-(chroman-7-oxygen) propoxyl group] benzoic acid 0.66g (0.002mol), diethylamine 0.15g (0.002mol), EDC0.42g (0.0022 mol), HOBt0.03g (0.0002mol), triethylamine 1.00g (0.01mol) to give 0.53g of white solid, yield 74.65%, mp: 129.3-131.2℃. LC-MS m / z: 354.2 ([M+H] + ),376.1([M+Na] + ),392.2([M+K] + ); 1 H-NMR (CDCl 3 )δ(ppm): 1.02(6H,t, J =2.4Hz),2.98(4H,q, J =2.4Hz),4.27(2H,m),4.34(2H,m),6.54(2H,d, J =8.4Hz),6.85(2H,d, J =7.5Hzt),7.02(2H,d, J =8.7Hz),7.12(2H,m),7.21(1H,d, J =7.8Hz),7.55(1H,d, J =8.4Hz),7.69(2H,d, J =8.7Hz); IR(KBr)υ / cm -1 : 3326, 2765, 1621, 1415, 1354, 1115, 1098, 1096, 1060, 732.
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