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Water-soluble carbon composite nano-material for double phototherapy, as well as preparation method and application thereof

A composite, water-soluble technology for biomedical applications

Active Publication Date: 2014-06-25
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation method is too complicated. In addition, the photosensitivity of phthalocyanine is not fully exerted by putting phthalocyanine into the interior of carbon nanohorns.

Method used

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  • Water-soluble carbon composite nano-material for double phototherapy, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0028] (1) Dissolve tetrasulfonic acid-based copper phthalocyanine with secondary water, prepare an aqueous solution with a mass concentration of 10%, and add single-walled Carbon nanohorns were ultrasonically ultrasonicated for 60 minutes.

[0029] (2) Centrifuge the ink-colored dispersion prepared above to remove large particle aggregates, filter the obtained liquid with a microporous membrane with a pore size of 220 nm, and wash with secondary water until the filtrate is colorless to remove free phthalocyanine. The obtained black solid was redispersed in water to obtain a single-wall carbon nanohorn-phthalocyanine complex with a total concentration of 1.4 mg / mL, of which phthalocyanine was 0.49 mg / mL and single-wall carbon nanohorn was 0.91 mg / mL .

[0030] The obtained single-wall carbon nanohorn-phthalocyanine complex can be uniformly dispersed in the water system and exist stably for at least 3 months.

[0031] Preparation Example 2

preparation Embodiment 2

[0033] (1) Dissolve tetrasulfonate-based aluminum phthalocyanine with secondary water, prepare an aqueous solution with a mass concentration of 12%, and add single-wall Carbon nanohorns were ultrasonically ultrasonicated for 60 minutes.

[0034] (2) Centrifuge the above-prepared dispersion to remove large particle aggregates, and filter the obtained liquid with a microporous membrane with a pore size of 220 nm, and wash it with secondary water until the filtrate is colorless to remove free phthalocyanine. After drying, the single-walled carbon nanohorn-phthalocyanine composite is obtained.

[0035] Preparation Example 3

preparation Embodiment 3

[0037] (1) Dissolve tetrasulfonic acid-based copper phthalocyanine with secondary water, prepare an aqueous solution with a mass concentration of 15%, and add a single layer of uncurled graphene, and ultrasonicated for 60 minutes with a sonicator.

[0038] (2) Centrifuge the above-prepared dispersion to remove large particle aggregates, filter the resulting liquid with a 200 nm pore filter, and wash with secondary water until the filtrate is colorless to remove free phthalocyanine. After drying, a single-layer uncurled graphene-phthalocyanine composite was obtained.

[0039] Preparation Example 4

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Abstract

The invention provides a water-soluble carbon composite nano-material for double phototherapy. The composite nano-material is a pi-pi planar conjugated complex formed by single-walled carbon nano-horns or monolayer curl-free graphene and water-soluble phthalocyanine. A preparation method of the water-soluble carbon composite nano-material comprises the following steps (1) dissolving the water-soluble phthalocyanine with secondary water to prepare a 10-15% aqueous solution, adding the single-walled carbon nano-horns or monolayer curl-free graphene accounting for 45-65 percent of the mass of the water-soluble phthalocyanine, and performing ultrasonic treatment for 30-180 minutes by using an ultrasonic device; and (2) centrifuging, carrying out suction filtering, washing and drying the prepared dispersant. The composite material has photo-thermal and photodynamic double treatment effects in the action of an infrared source, so that the efficiency for killing tumor cells can be strengthened; the preparation method is simple and convenient; the one-step ultrasonic method not only can solve the problem of water solubility of single-walled carbon nano-horns or monolayer curl-free graphene, but also enables the photodynamic treatment preparation to be loaded, and the surface characteristics of the carbon composite nano-material cannot be destroyed by adopting non-covalent modification.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a phototherapy agent, more specifically to a dual phototherapy water-soluble carbon nanocomposite material and its preparation method and application. Background technique [0002] Phototherapy is a non-invasive treatment technology using visible light or near-infrared light irradiation. It has unique advantages such as remote controllability, high selectivity and low systemic toxicity. It has broad application prospects in the treatment of malignant tumors. Photothermal therapy and photodynamic therapy are two different forms of phototherapy currently widely used in tumor treatment. Photothermal therapy is the use of photothermal reagents to absorb light of specific wavelengths, and convert the absorbed energy into heat through non-radiative attenuation, resulting in an increase in local environmental temperature and irreversible damage to diseased cells. Photother...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/48A61P35/00
Inventor 沈星灿胡兰芳蒋邦平
Owner GUANGXI NORMAL UNIV
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