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Application of lettuce glucoside B in preparation of medicines for prevention and treatment of kidney transplant

A technology of lettucoside and kidney transplantation, which is applied in the field of application of raptucoside B in the preparation of drugs for the prevention and treatment of kidney transplantation, can solve the problems of no reports on the application of raptucoside B in the prevention and treatment of kidney transplantation, and achieve good application prospects and prolong Survival time, effect of improving renal function

Active Publication Date: 2014-06-25
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is no report on the application of lettucoside B in the prevention and treatment of kidney transplantation

Method used

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  • Application of lettuce glucoside B in preparation of medicines for prevention and treatment of kidney transplant
  • Application of lettuce glucoside B in preparation of medicines for prevention and treatment of kidney transplant
  • Application of lettuce glucoside B in preparation of medicines for prevention and treatment of kidney transplant

Examples

Experimental program
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Effect test

experiment example 1

[0031] Experimental Example 1: Effects of Lactucoside B on Renal Function and Survival Time after Kidney Transplantation in Rats

[0032] 1. Experimental animals: 50 male Wistar rats and 50 SD rats each, weighing 200-250 g, purchased from the Experimental Animal Center of Zhengzhou University.

[0033] 2. Experimental reagents and instruments:

[0034] Lactucoside B, prepared by the School of Pharmacy, Xinxiang Medical College, with a purity greater than 95%;

[0035] The blood urea nitrogen detection kit, blood creatinine detection kit, urine protein detection kit, heparin (25IU / mL) balance solution, and 1% ketamine injection were all provided by Weijia Technology Co., Ltd.

[0036] 3. Drug configuration

[0037] Weigh the required dose of Lactucoside B, dissolve it in sterile double-distilled water, prepare it freshly before each administration, and store it away from light.

[0038] 4. Experimental grouping and experimental methods:

[0039] 4.1 Establishment of the ani...

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Abstract

The invention relates to a new application of lettuce glucoside B, and particularly relates to an application of the lettuce glucoside B in preparation of medicines for prevention and treatment of kidney transplant. Experiments show that the lettuce glucoside B can be used for improving the renal function of rats subjected to kidney transplant and prolonging the survival time of the transplant kidney, the effects take on dosage dependency relationship, and the lettuce glucoside has a treatment effect on the transplant kidney.

Description

technical field [0001] The present invention relates to the new application of Lactucoside B, in particular to the application of Lactucoside B in the preparation of medicines for preventing and treating kidney transplantation. Background technique [0002] Kidney transplantation is the transplantation of healthy kidneys to individuals with severe kidney disease or severely impaired kidney function. It is an effective means of treating severe kidney diseases such as renal failure and uremia. Although with the development of surgical techniques, the one-year survival rate of kidney transplant patients has reached over 90%, but the five-year survival rate is only 50%-80%, with an average survival rate of 60%, and kidney transplant patients need to take cyclosporine for life High-efficiency immunosuppressants such as factor A, and these immunosuppressants have relatively strong inhibitory effects on the body's immune system and other systems, seriously affecting the quality of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/365A61P13/12
Inventor 海广范郭兰青闫福林杨汇娟卢颖李品品韩金芬
Owner XINXIANG MEDICAL UNIV
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