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A traditional Chinese medicine composition for treating irritable bowel syndrome and its preparation method

A technology for irritable bowel syndrome and composition, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of lack of drugs, limitation, and unsatisfactory curative effect, etc., and achieve the effect of good curative effect.

Active Publication Date: 2017-07-28
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the in-depth research on enteric nervous system mediators and their receptors, 5-HT receptor modulators can not only regulate colon motility response but also reduce visceral hypersensitivity, but they can also cause severe constipation and dyspepsia in patients with diarrhea-type IBS. Clinical use is limited due to bloody enteritis
In addition, the therapeutic effect of drugs on IBS-D will decrease over time, and the disease is prone to relapse. For example, trimebutine maleate can significantly improve the symptoms of abdominal pain and diarrhea in patients with diarrhea-type IBS. The total effective rates at one month were 79.5% and 51.4%, respectively. The short-term curative effect was better, but the mid-term and long-term curative effect was not ideal, and the total effective rate decreased significantly at 3 months, only 31.4%.
The current clinical treatment is still unsatisfactory. All in all, there is still a lack of completely effective drugs for the treatment of IBS, and an ideal and effective treatment plan has not yet been formed.
[0004] However, these drug treatments cannot fundamentally solve the problem. For details, see Bian Liqun et al.'s article "Thoughts on Constructing a Curative Effect Evaluation System of Traditional Chinese Medicine for Irritable Bowel Syndrome" (World Chinese Journal of Digestion, 2010, 18(21): 2221-2224 )

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of Chang'an No. 1 Prescription of Chinese Medicine Composition for the Treatment of Irritable Bowel Syndrome

[0021] 1) Weigh 500 grams of astragalus, 500 grams of fried Atractylodes macrocephala, 650 grams of fried white peony root, 250 grams of Fangfeng, 160 grams of Coptis chinensis, 160 grams of paojiang charcoal, 250 grams of nutmeg, 250 grams of Qing Pinellia, 320 grams of simmering wood fragrance, 160 grams of roasted licorice, 250 grams of tangerine peel;

[0022] 2) Extract Astragalus and Coptidis with 8 times the amount of 70% ethanol for 3 times, each time for 2 hours; combine the ethanol extracts, recover ethanol, concentrate properly, and dry; nutmeg, simmering wood and tangerine peel are properly crushed, and added 10 times Measure water, extract volatile oil with steam distillation, extraction time is 8 hours. Collect the volatile oil, wrap it with cyclodextrin, refrigerate overnight, dry at low temperature, and use the mother liqu...

Embodiment 2

[0023] Embodiment 2: the preparation of decoction

[0024] 1) Weigh 90 grams of astragalus, 90 grams of fried Atractylodes macrocephala, 120 grams of fried white peony root, 45 grams of Fangfeng, 30 grams of Coptis chinensis, 30 grams of paojiang charcoal, 45 grams of nutmeg, 45 grams of Qing Pinellia, 60 grams of simmering wood fragrance, 30 grams of roasted licorice, 45 grams of tangerine peel;

[0025] 2) Add water to decoct the medicinal material for 2-3 times, combine the medicinal liquid, filter and concentrate to obtain a decoction.

Embodiment 3

[0026] Embodiment 3: the preparation of capsule

[0027] 1) Weigh 250 grams of astragalus, 250 grams of fried Atractylodes macrocephala, 320 grams of fried white peony root, 120 grams of Fangfeng, 80 grams of Coptis chinensis, 80 grams of paojiang charcoal, 120 grams of nutmeg, 120 grams of Qing Pinellia, 160 grams of simmering wood fragrance, 80 grams of roasted licorice, 120 grams of tangerine peel;

[0028] 2) Extract Astragalus and Coptidis with 8 times the amount of 70% ethanol for 3 times, each time for 2 hours; combine the ethanol extracts, recover ethanol, concentrate properly, and dry; nutmeg, simmering wood and tangerine peel are properly crushed, and added 10 times Measure water, extract volatile oil with steam distillation, extraction time is 8 hours. Collect the volatile oil, wrap it with cyclodextrin, refrigerate overnight, dry at low temperature, and use the mother liquor for later use; extract Atractylodes macrocephala, fried white peony root, Paojiang charcoa...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating irritable bowel syndrome of liver stagnation and spleen deficiency type. Fragrance, roasted licorice, and tangerine peel Chinese medicinal materials are used as medicinal components, which can be added with commonly used pharmaceutical excipients to make various oral dosage forms. Since its clinical use, it has a remarkable curative effect on improving symptoms. The invention also discloses a preparation method of the composition.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating irritable bowel syndrome of liver stagnation and spleen deficiency type, and also relates to a preparation method of the composition. Background technique [0002] Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with a high incidence worldwide, and its main symptoms are abdominal pain or discomfort accompanied by changes in bowel habits. IBS is one of the most common functional gastrointestinal diseases clinically. Although it is not life-threatening, it can affect work and life to varying degrees, occupy a large amount of medical resources, and cause a serious decline in quality of life. In recent years, it has become a research topic at home and abroad. hotspot. [0003] At present, there are many drugs for the treatment of IBS clinically, which can be roughly classified into the following four categories: drugs that regulate intestinal motility...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/00A61K33/12A61K35/618
Inventor 唐旭东
Owner SHIJIAZHUANG YILING PHARMA
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