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A kind of bone cement and preparation method thereof

A technology of bone cement and ammonium phosphate, applied in medical science, prosthesis, etc., can solve problems such as difficulty in achieving the expected purpose, difficulty in removing auxiliary materials completely, and difficulty in obtaining porosity, etc., and achieves large adhesion surface and good mechanical properties. , the effect of excellent biocompatibility and bioactivity

Active Publication Date: 2015-09-02
NINGBO HICREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the porous bone cements prepared by the above methods all have certain shortcomings: first, the formulation process is relatively complicated, often need to add some auxiliary materials, and the auxiliary materials are difficult to completely remove; secondly, its degradation time is difficult to match with the cell growth cycle, It makes it difficult for cells to grow into it, and it is difficult to achieve the expected purpose; again, the obtained micropores have different pore sizes, and it is difficult to obtain a relatively stable porosity; the biodegradability is poor, etc.

Method used

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  • A kind of bone cement and preparation method thereof
  • A kind of bone cement and preparation method thereof
  • A kind of bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Weigh 2.7g of magnesium oxide powder with a particle size of 10μm-80μm, 2.15g of ammonium dihydrogen phosphate powder, and 0.15g of sodium tetraborate powder. Grind and disperse the above three powders evenly in a mortar, add 0.4ml of normal saline, blend into a uniform mud mass with a dental knife, and then put it into a 37°C, 100% humidity environment for 2 hours to cure. The strength of the cured body is good.

Embodiment 2

[0063] Weigh 2.585g (51.7%) of magnesium oxide powder with a particle diameter of 30 μm-50 μm, 2.355 g (47.1%) of ammonium dihydrogen phosphate powder, 0.059 g (1.18%) of boric acid powder, and 0.001 g (0.02%) of magnesium metal powder ). Grind and disperse the above four powders in a mortar evenly, add 3ml of magnesium chloride solution, use a dental knife to blend into a uniform mud mass, then put it in a 37°C 100% humidity environment for 2 hours, and use a microscope to detect the pore size distribution of the sample Uniform, the pore size is about 250+20μm, the porosity is 75%, and the compressive strength is about 8.8MPa. figure 1 The reaction exothermic temperature curves of the ordinary MPC prepared according to Example 1 and the MPC-Mg bone cement prepared according to Example 2 are shown. From figure 1 It can be seen that compared with ordinary MPC bone cement, the exothermic temperature of MPC bone cement mixed with metal magnesium powder is slightly higher than t...

Embodiment 3

[0067] Weigh 3.12g (60.89%) of magnesium oxide powder, 1.804g (35.2%) of diammonium hydrogen phosphate powder, 0.03g (0.59%) of sodium tetraborate powder, and 0.17g of magnesium metal powder with a particle size of 60 μm-80 μm (3.32%). Grind and disperse the above four powders in a mortar evenly, add 2ml of deionized water solution, use a dental knife to blend into a uniform mud mass, and then put it into a 370 (2100% humidity environment) to cure for 2 hours, and use a microscope to detect. The sample pore size The distribution is uniform, the pore size is about 150+20μm, the porosity is 55%, and the compressive strength is about 4.5MPa.

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Abstract

The invention relates to novel bone cement and a preparation method thereof. The novel bone cement consists of the following components in percentage by weight: 47-78wt% of magnesium oxide, 20-50wt% of ammonium phosphate, 0.5-10wt% of retarder, 0.01-10wt% of magnesium powder and a solidifying liquid, wherein the liquid-solid ratio of the solidifying liquid to the mixture of the materials is 0.06-1.0ml / g. According to the novel bone cement and the preparation method thereof disclosed by the invention, the system is accelerated to generate ammonia gas to form pores by adding the magnesium powder into the system of ammonium phosphate and magnesium oxide. The preparation process provided by the invention is simple and convenient. According to the porous structure obtained by the method, the pore size is uniform and the porosity is great, so that cell adsorption and climbing are facilitated, thereby promoting the growth of bone cells. The novel bone cement provided by the invention has good mechanical properties, biocompatibility and biocompatibility and can be widely applied to the field of medical materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a novel bone cement and a preparation method thereof, more specifically, to a porous degradable magnesium phosphate bone cement containing metal magnesium powder and a preparation method thereof. Background technique [0002] Magnesium Phosphate Bone Cement (MPC) has been studied as a biological material, and reports at home and abroad are mainly used as dental cement, artificial joint adhesive, bone stabilizer, etc. Magnesium phosphate bone cement has been praised by many experts and scholars due to its biocompatibility and bioactivity, and is considered to be one of the most potential bone repair and replacement materials at present. The material has no toxic reaction and good biocompatibility when implanted in animals. After solidification, it is closely connected with the bone and gradually absorbed, which promotes the growth of bone cells and guides the growth of new bone. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/04A61L27/58A61L27/56A61L27/54
Inventor 张鹏云王陈毛克亚徐嘉麟
Owner NINGBO HICREN BIOTECH
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