Cefuroxime axetil composition and preparation method thereof

A cefuroxime axetil and composition technology, which is applied in the field of cefuroxime axetil composition and its preparation, can solve the problems of destroying the integrity of the drug package and not effectively covering the bitter taste of the drug, and achieve high bioavailability of the drug. The effect of short time and uniform drug content

Active Publication Date: 2014-05-28
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method also uses stearic acid as a taste-masking agent to coat the drug, but it is granulated in a pulverized manner, which seriously damages the integrity of the drug package, and the bitter taste of the drug is not effectively masked

Method used

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  • Cefuroxime axetil composition and preparation method thereof
  • Cefuroxime axetil composition and preparation method thereof
  • Cefuroxime axetil composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of cefuroxime axetil composition and its dry suspension (based on 1000 parts, each containing 0.125 g of cefuroxime)

[0031] Element Dosage (g) Cefuroxime axetil (calculated as cefuroxime) 125 stearic acid 500 Sucrose stearate 33

[0032] (1) Preparation of the cefuroxime axetil composition: Heat and melt stearic acid and sucrose stearate in the prescribed amount in the above table, mix well, add cefuroxime axetil in the prescribed amount, mix evenly, and atomize The pressure is 0.18~0.24bar, and the inlet air temperature is -4~1℃ for spray granulation.

[0033] The micrograph (10×10 times) of raw material cefuroxime axetil is as figure 1 And the cefuroxime axetil composition particle diameter micrograph (10 * 10 times) that the present embodiment makes is as figure 2 shown. From figure 1 It can be seen that the particle size of cefuroxime axetil particles is small, and its average particle size is 7.4um. ...

Embodiment 2

[0035] Example 2 Preparation of cefuroxime axetil composition and its dry suspension (based on 1000 parts, each containing 0.125 g of cefuroxime)

[0036] Element Dosage (g) Cefuroxime axetil (calculated as cefuroxime) 125 stearic acid 500 Sucrose stearate 69

[0037] (1) Preparation of the cefuroxime axetil composition: Heat and melt stearic acid and sucrose stearate in the prescribed amount in the above table, mix well, add cefuroxime axetil in the prescribed amount, mix evenly, and atomize The pressure is 0.2~0.24bar, and the inlet air temperature is -1~3℃ for spray granulation.

[0038] (2) Preparation of dry suspension of cefuroxime axetil composition: mix the cefuroxime axetil composition prepared in step (1) with 15g xanthan gum and 2960g sucrose evenly, granulate in a fluidized bed, dry, add 20g of blackcurrant essence, mixed evenly to obtain a dry suspension product.

Embodiment

[0039] Example 3 Preparation of cefuroxime axetil composition and its granules (based on 1000 parts, each containing 0.125 g of cefuroxime)

[0040] Element Dosage (g) Cefuroxime axetil (calculated as cefuroxime) 125 stearic acid 250 Glyceryl behenate 250 Sucrose Palmitate 15

[0041] (1) Preparation of the cefuroxime axetil composition: Heat and melt the stearic acid, glyceryl behenate and sucrose palmitate in the prescribed amount in the above table, mix well, add the prescribed amount of cefuroxime axetil, mix evenly Finally, spray granulation with the atomization pressure at 0.18~0.25bar and the inlet air temperature at -2~3°C.

[0042] (2) Preparation of cefuroxime axetil composition granules: mix the cefuroxime axetil composition prepared in step (1) with 15g xanthan gum and 2900g sucrose evenly, granulate in a fluidized bed, dry, add 20g black Gallon essence, mix evenly to get granule product.

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Abstract

The invention discloses a cefuroxime axetil composition and a preparation method thereof. The cefuroxime axetil composition can effectively cover bitter taste of a cefuroxime axetil medicine so as to improve the delivery compliance of the patient. Meanwhile, the medicine containing the cefuroxime axetil composition has higher dissolution rate and high bioavailability. The composition disclosed by the invention can be further used for preparing dry suspensions or granules which are more beneficial for infants, children and patients without the ability of swallowing to take. The composition disclosed by the invention is simple in preparation method, free from any solvents, uniform in medicine content, short in heating time, small in energy consumption and easy to realize continuous large-scale production.

Description

technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to a cefuroxime axetil composition and a preparation method thereof. Background technique [0002] Cefuroxime Axetil is white or off-white powder with extremely bitter taste. It has the advantages of broad antibacterial spectrum, strong antibacterial effect, high curative effect, low toxicity, and small side effects, and is a commonly used antibiotic in clinical practice. Its bactericidal mechanism is to inhibit the synthesis of bacterial cell walls, resulting in cell death. At present, the oral dosage forms of cefuroxime axetil include tablets, capsules, granules and suspensions. However, tablets and capsules are obviously not suitable for infants, children and other patients who have difficulty swallowing. The dosage forms such as granules or suspensions are considered to be ideal dosage forms due to their advantages of convenient administration and ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/14A61K31/546A61K47/26A61P31/04
Inventor 余楚钦林华庆石忠峰邓艳斌林的仕林苏娜
Owner GUANGDONG PHARMA UNIV
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