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Method for extracting paeonol by use of CO2 supercritical extraction technology

An extraction technology, the technology of paeonol, which is applied in the field of extraction of traditional Chinese medicine components, can solve the problems of easy volatilization, low content and yield of paeonol, low melting point of paeonol, achieve low extraction temperature, short extraction time, overcome volatile effect

Inactive Publication Date: 2014-05-14
XUANCHENG BAICAO PLANT IND & TRADE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low melting point of paeonol and its volatility, the higher the temperature and the longer the time in the extraction process, the lower the content and yield of paeonol, so the existing extraction methods have obvious deficiencies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) Take the raw material peony cortex, wash it, ventilate and dry it to remove the moisture in the peony cortex, make the moisture content lower than 10%, then send it to the pulverizer and pulverize it into a raw material powder with a particle size of 40 mesh, add 3 times the amount of anhydrous Ethanol, at a frequency of 20Hz and a power of 500W, sonicate for 15s, intermittently for 15s, and process for a total of 30min. After filtering, dry and mix with β-cyclodextrin at a mass ratio of 2:1, granulate, pass through a 20-mesh sieve, and dry ,stand-by;

[0014] (2) Take emu oil equivalent to 10% of the weight of the raw material powder as an entrainer and mix it evenly with the raw material powder, send the granulated particles into a supercritical extraction kettle, and input CO at a flow rate of 2 l / h 2 The fluid is extracted under the conditions of extraction pressure 20MPa, extraction temperature 45°C, extraction time 2h;

[0015] (3) Refrigerate the paeonol ext...

Embodiment 2

[0017] (1) Take the raw material peony cortex, wash it, ventilate and dry it to remove the moisture in the peony cortex, make the moisture content lower than 10%, then send it to the pulverizer and pulverize it into a raw material powder with a particle size of 60 mesh, add 4 times the amount of anhydrous Ethanol, at a frequency of 25Hz and a power of 600W, sonicate for 10s, intermittently for 10s, and process for 20min in total. After filtering, dry it and mix it with β-cyclodextrin at a mass ratio of 3:1, granulate, pass through a 40-mesh sieve, and dry ,stand-by;

[0018] (2) Take emu oil equivalent to 15% of the weight of the raw material powder as an entrainer and mix it evenly with the raw material powder, send the granulated particles into a supercritical extraction kettle, and input CO at a flow rate of 3 l / h 2 The fluid is extracted under the conditions of extraction pressure 30MPa, extraction temperature 50°C, extraction time 3h;

[0019] (3) Refrigerate the...

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Abstract

The invention discloses a method for extracting paeonol by use of the CO2 supercritical extraction technology. The method comprises the following steps: washing cortex moutan, drying, grinding, seiving and performing ultrasonic treatment; adding an appropriate amount of beta-cyclodextrin, granulating and drying; uniformly mixing emu oil serving as an entrainer with the raw material powder; feeding the granulated particles into a supercritical extraction kettle for CO2 supercritical extraction; refrigerating the paeonol extract liquid in the supercritical extraction kettle and taking out to obtain an automatic-layering extract, wherein the upper layer is light yellow liquid, and the lower layer is light red brown solid; and separating the liquid to obtain high-purity active monomer paeonol. The method disclosed by the invention has the advantages of simple extraction process, high extraction rate, low extraction temperature, short extraction time and the like; the yield of paeonol can exceed 1.4%; and moreover, CO2 is non-toxic and residue-free, the energy consumption is reduced, cyclic use can be realized, the shortcomings of the traditional extraction method that the paeonol is easily volatilized and the yield is low are overcome, and the application prospect is broad.

Description

technical field [0001] The present invention relates to a method using CO 2 The invention discloses a method for extracting paeonol by supercritical extraction technology, which belongs to the technical field of extraction of traditional Chinese medicine components. Background technique [0002] Cortex Moutan is the dry root bark of the tree peony of Ranunculaceae. Produced in Anhui, Shandong and other places. The roots are excavated in autumn, the fine roots are removed, the root bark is stripped, and dried in the sun. Use raw or fried. "Compendium of Materia Medica": "Nourishing yin and reducing fire, detoxifying spot poisoning, benefiting throat, clearing blood stagnation in urination. Later generations use yellow tiller to treat phase fire, but they don't know that the power of paeonol is better. The red flower is beneficial, and the white flower is nourishing. , People are also rarely aware of it, so it is advisable to separate them." Its main components include pae...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/84C07C45/78
CPCC07C45/78C07C45/79C07C49/84Y02P20/54
Inventor 徐家龙
Owner XUANCHENG BAICAO PLANT IND & TRADE CO LTD
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