Secnidazole vagina expansive suppository and preparation method and detection method thereof

Abstract

The invention relates to a secnidazole vagina expansive suppository and a preparation method and a detection method thereof. The secnidazole vagina expansive suppository comprises secnidazole, a matrix and an expansive carrier, wherein the medicine-containing matrix of the expansive suppository contains triethanolamine oleate so that the dispersion uniformity of the secnidazole in the matrix can be increased and the bioavailability of the suppository is increased; the thyme oil is capable of improving the lubricating property of the suppository and the dissolution rate of the secnidazole as an active ingredient, the absorption of a human body to the secnidazole is increased, and the bioavailability of the suppository is improved; the glucosan is capable of improving the treatment effect of the suppository on vulvovaginal candidiasis, promoting the recovery of the erosion and the anabrosis, and improving the immunity of the human body; the glucosan is capable of promoting the formation of the suppository, and improving the stability of the suppository; the secnidazole vagina expansive suppository is a hollow dual-layer expansive suppository, the medicine-containing matrix is wrapped in a matrix layer so that the suppository disclosed by the invention is more stable than a common suppository; meanwhile, the secnidazole vagina expansive suppository has the beneficial effects of preventing a medicine liquid from outflowing, being high in stability, remarkable in treatment effect, and the like by adopting six creative leading technologies.

Description

Technical field [0001] The invention belongs to the field of vaginal suppositories, and particularly relates to a secnidazole vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] Secnidazole is mainly used to treat trichomonas vaginitis. Trichomonas vaginitis is caused by Trichomonas. Trichomonas parasitizing the human body are Trichomonas vaginalis, Trichomonas hominis and Trichomonas oral cavity, which parasitize the urogenital system, intestines and oral cavity respectively, and are related to skin diseases. It is Trichomonas vaginalis, which causes trichomonas vaginitis. It is a parasitic disease that is spread mainly through sexual intercourse and is contagious. The preparations related to secnidazole in the prior art include tablets, injections and suppositories, etc. The tablets and injections generally have inconvenience to use, low dissolution of secnidazole, difficult absorption, and low bioavailability. ...

AI Technical Summary

Problems solved by technology

The preparations related to secnidazole in the prior art include tablets, injections and suppositories, etc. The tablets and injections generally have the disadvantages of inconvenient use, low dissolution rate of secnidazole, difficult absorption, and low bioavailability and other adverse reactions, while ordinary suppositories are easy to use, but they also have problems such as difficulty in absorption and low bioavailability; at the same time, the liquid medicine is easily excreted from the body, contaminates clothes, and is not easy to clean; the sliver in the suppository does not expand or expand disorderly, Reduce clinical application; Unreliable quality control methods lead to large variations in batch-to-batch content, stability, and melting time limit in the actual production process; active ingredients cannot fully exert their curative effects, etc.

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