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Regenerated active artificial implant for osteoporosis therapy and preparation method thereof

A technology for osteoporosis and implants, applied in prosthetics, medical science, coatings, etc., can solve problems such as incomplete integration of materials and human bone interfaces, joint looseness, etc., to prevent loosening and falling off, and bone bonding force The effect of increasing and promoting bone mass formation

Inactive Publication Date: 2014-05-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has some problems. The incidence of prosthetic loosening can reach 2%-24%. The reason is that the interface between the material and the human bone cannot be perfectly combined, resulting in artificial joint problems such as osteolysis and joint loosening after replacement.

Method used

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  • Regenerated active artificial implant for osteoporosis therapy and preparation method thereof
  • Regenerated active artificial implant for osteoporosis therapy and preparation method thereof
  • Regenerated active artificial implant for osteoporosis therapy and preparation method thereof

Examples

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Effect test

Embodiment Construction

[0018] The present invention is used for the preparation method of the regenerative activity artificial implant of osteoporosis treatment, comprises the following steps:

[0019] 1. Grind the smooth titanium plate with 0.25-0.5mm large particle emery, then ultrasonically clean it with acetone, ethanol with a volume percentage of 75% and distilled water for 15 minutes each, and then use HF with a concentration of 1.375mol / L and a concentration of 1.97mol / L HN0 3 After soaking in the mixed solution for 2min, rinse with double distilled water, and then use H2O with a concentration of 3.73 mol / L 2 S0 4 After immersing in a mixture of HCl with a concentration of 3.2 mol / L at 37 °C for 30 min, rinse with double distilled water, and dry at 37 °C to obtain a frosted acid-etched roughened titanium plate.

[0020] 2. The above-mentioned frosted acid-etched titanium plate with a rough surface is soaked in a NaOH solution with a concentration of 5 mol / L at 60°C for 24 hours, rinsed wi...

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Abstract

The invention discloses a regenerated active artificial implant for osteoporosis therapy and a preparation method thereof. The regenerated active man-made implant comprises a tooth implant with titanium or titanium alloy as a base and an artificial bone joint medical hard tissue implant material. The base material surface is subjected to serial nano-micron treatment and simvastatin-containing improved bionic liquid treatment to form a nano bionic coating structure with regeneration activity and bone mass formation promoting effect; the nano coating crystal grains on the surface of the implant are bone-like hydroxyapatite substance rich in calcium and phosphorous; the nano-micron bionic coating implant has bone regeneration promoting activity and high affinity, and compared with coating-free materials, the nano-micron bionic coating implant has remarkably increased binding force with bone so as to effectively prevent the implant from loose and fallout phenomena; the simvastatin-containing calcium / phosphorus bionic coating implant is a novel medical implant material with bone mass formation promoting effect and regeneration activity.

Description

technical field [0001] The invention relates to a regenerative active artificial implant (such as a dental implant, artificial bone joint implant) medical material and a preparation method with the effect of treating osteoporosis. Background technique [0002] With the aggravation of the aging population and the increase of joint damage caused by various injuries, it often leads to changes in the joint structure. Medication alone can only partially relieve pain symptoms, and it is difficult to improve joint function. Artificial joint replacement can achieve the purpose of relieving pain, stabilizing joints, correcting deformities, and improving joint function. Such as pain caused by rheumatoid arthritis, old joint dislocation, etc., through artificial joint surgery, joint deformities can be significantly corrected, and the original stiff joints can return to normal functions. Joint pain and severe dysfunction caused by many diseases are suitable for artificial joint replace...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/54A61L27/32
Inventor 严伟祺齐义营
Owner ZHEJIANG UNIV
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