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Combinatorial drug of ceftazidime

A ceftazidime and drug technology, applied in the field of ceftazidime combination medicine and its preparation, can solve the problems of increased product storage cost and transportation cost, inconvenient storage and transportation, unstable storage, etc. Effect, curative effect stable effect

Inactive Publication Date: 2014-05-07
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, because ceftazidime for injection is not stable in the greenhouse, it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience to storage and transportation, and also increases the cost of product storage and transportation. cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Invent a kind of combination medicine of ceftazidime, be made up of the effective medicinal ingredient of following parts by weight:

[0025] Ceftazidime 80

[0026] Glutathione 20

[0027] Arginine 8

[0028] Lysine 10

[0029] The method of described ceftazidime combination medicine, its preparation method and steps are as follows:

[0030] (1). Take water for injection whose weight is 5-15 times that of the ceftazidime, and under stirring, respectively dissolve the ceftazidime, glutathione, arginine, and lysine completely to obtain a combined drug solution of ceftazidime ;

[0031] (2). The liquid medicine obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D, and the filtrate is adjusted to a pH value of 6.3-7.4 with 8% sodium hydroxide solution;

[0032] (3). The liquid medicine obtained in step (2) was steam...

Embodiment 2

[0038] Invent a kind of combination medicine of ceftazidime, be made up of the effective medicinal ingredient of following parts by weight:

[0039] Ceftazidime 93

[0040] Glutathione 31

[0041] Arginine 19

[0042] Lysine 16

[0043] The method of described ceftazidime combination medicine, its preparation method and steps are as follows:

[0044] (1). Take water for injection whose weight is 5-15 times that of the ceftazidime, and under stirring, respectively dissolve the ceftazidime, glutathione, arginine, and lysine completely to obtain a combined drug solution of ceftazidime ;

[0045] (2). The liquid medicine obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D, and the filtrate is adjusted to a pH value of 6.3-7.4 with 8% sodium hydroxide solution;

[0046] (3). The liquid medicine obtained in step (2) was stea...

Embodiment 3

[0052] Invent a kind of combination medicine of ceftazidime, be made up of the effective medicinal ingredient of following parts by weight:

[0053] Ceftazidime 100

[0054] Glutathione 40

[0055] Arginine 29

[0056] Lysine 26

[0057] The method of described ceftazidime combination medicine, its preparation method and steps are as follows:

[0058] (1). Take water for injection whose weight is 5-15 times that of the ceftazidime, and under stirring, respectively dissolve the ceftazidime, glutathione, arginine, and lysine completely to obtain a combined drug solution of ceftazidime ;

[0059] (2). The liquid medicine obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D, and the filtrate is adjusted to a pH value of 6.3-7.4 with 8% sodium hydroxide solution;

[0060] (3). The liquid medicine obtained in step (2) was ste...

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Abstract

The invention provides a combinatorial drug of ceftazidime. The combinatorial drug is characterized by being prepared from the pharmacodynamic components: ceftazidime, glutathione, arginine and lysine, of which the ratio in parts by weight is (80-110):(20-60):(8-55):(10-40). A preparation method of the combinatorial drug is provided. The combinatorial drug of the ceftazidime disclosed by the invention is superior to the prior art in safety, stability and curative effect, and the preparation method is energy-saving and environment-friendly.

Description

technical field [0001] The invention relates to a combination medicine of ceftazidime and a preparation method thereof. Background technique [0002] Ceftazidime is a semi-synthetic third-generation cephalosporin. The product is free acid (pentahydrate), and a certain amount of anhydrous sodium carbonate is added to make injection for use. It is suitable for sepsis caused by sensitive Gram-negative bacilli, lower respiratory system infection, abdominal cavity and biliary system infection, complicated urinary tract infection and severe skin and soft tissue infection. At present, because ceftazidime for injection is not stable in the greenhouse, it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience to storage and transportation, and also increases the cost of product storage and transportation. cost. In addition, those with drug allergies, adverse reactions to the gastrointestinal tract, liver syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K47/18A61P31/04A61P1/16
Inventor 邓学峰
Owner 邓学峰
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