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Preparation method of paclitaxel dressing bin and prepared paclitaxel dressing bin

The technology of paclitaxel and dressing chamber, which is applied in the field of drug preparation, can solve the problems of paclitaxel insolubility, limit the clinical application of paclitaxel, and increase the toxicity and side effects, and achieve the effects of low cost, overcoming toxicity and side effects, and simple process

Active Publication Date: 2014-05-07
安徽爱喆生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing dosage form of paclitaxel is mainly an injection type, but paclitaxel is insoluble in water, and its injection needs to add a cosolvent, and the toxic and side effects increase with the increase of the dose
These characteristics limit the clinical application of paclitaxel, and the study of new dosage forms has become a hot spot of paclitaxel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] A preparation method of paclitaxel dressing chamber, is characterized in that, comprises the following steps:

[0022] (1) Weigh paclitaxel 2 and lecithin S80 20 by weight (g);

[0023] (2) Measure 10ml of Tween 80 and 10ml of absolute ethanol and mix them into an emulsifier;

[0024] (3) Fully stir and mix the above materials to make material A;

[0025] (4) Weigh yellow vaseline 8, liquid paraffin 1.0, and lanolin 1.0 by weight (g), stir and mix well to make material B;

[0026] (5) Measure 4ml of water-soluble laurocapram, 12ml of glycerin, add 8ml of purified water, stir and mix to make material C;

[0027] (6) Select non-woven fabric as the bottom cotton, and coat the material B on the bottom cotton with a coating thickness of 2ml;

[0028] (7) Fix the absorbent cotton in the middle of the bottom cotton, and alternately spray material C and material A on the absorbent cotton through the sugar coating machine, with an interval of 1 minute each time;

[0029] (8)...

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PUM

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Abstract

The invention provides a preparation method of a paclitaxel dressing bin. The preparation method comprises the steps: after uniformly mixing paclitaxel, lecithin and various accessories, coating on bottom cotton and medicine cotton, finally preparing the bin, and applying to a focus position by using an ultrasonic 3 MHZ guide instrument during use. The preparation method is low in cost, and simple in process; the prepared paclitaxel dressing bin is used for preventing and controlling breast cancer, and applied to the focus position by arranging the ultrasonic 3 MHZ guide instrument. The toxic and side effects of an existing paclitaxel injection are overcome.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a method for preparing a paclitaxel dressing chamber and the prepared paclitaxel dressing chamber. Background technique [0002] Paclitaxel is a natural product with antitumor activity, which has a novel chemical structure and a unique mechanism of action. Experimental studies have shown that it has obvious toxic effects on the mitosis of cancer cells, and it is a newly discovered mitosis inhibitor. Its mechanism of action is different from that of commonly used anticancer chemotherapeutic drugs, mainly in that taxol induces and promotes the formation of microtubules in cancer cells, prevents the normal physiological aggregation of microtubules, inhibits the mitosis and spindle formation of cancer cells, and then Hinder the proliferation of cancer cells, resulting in fast-dividing cancer cells being limited to the mitotic stage, thereby blocking the replication of cancer ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/337A61P35/00
Inventor 卢开朗杨冬雪
Owner 安徽爱喆生物医药科技有限公司
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