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Preparation method of Qingmei cold-treatment tablet and use of Qingmei cold-treatment tablet in drug for inhibiting leukemia cell L1210 proliferation

A green plum cold tablet and extraction technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of large dosage for patients, many impurities, and rough process, so as to achieve small dosage and reduce dosage , The effect of taking the dose without bitterness

Inactive Publication Date: 2014-04-30
侯玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingmei Ganmao Granules. However, the method of extracting volatile oil and decocting in water is rough and backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affected the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of fenugreek, 200g of dog liver dish, 134g of licorice, 134g of Centella asiatica, 267g of Gangmei, and add Artemisia annua and lavender to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. For 8 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduce...

Embodiment 2

[0033] Take 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of fenugreek, 200g of dog liver dish, 134g of licorice, 134g of Centella asiatica, 267g of Gangmei, and add Artemisia annua and lavender to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent, the extraction pressure is 30MPa, the temperature is 50°C, and CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. Combine the extracts for 5 minutes each time, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure...

Embodiment 3

[0036] Take 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of fenugreek, 200g of dog liver dish, 134g of licorice, 134g of Centella asiatica, 267g of Gangmei, and add Artemisia annua and lavender to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. For 10 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under re...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and relates to a preparation method and a use of a Qingmei cold-treatment tablet. Through supercritical extraction and microwave extraction, the Qingmei cold-treatment tablet is prepared from 200g of sweet wormwood, 267g of fingered citron, 134g of Chinese mosla herb, 200g of Strobilanthes tetraspermus, 134g of licorice root, 134g of herba centellae and 267g of holly root. The glycyrrhizic acid content of the Qingmei cold-treatment tablet is greatly improved. The invention also provides the use of the Qingmei cold-treatment tablet in preparation of the drug for inhibiting mouse leukemia cell L1210 proliferation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Qingmei Ganmao tablet and its application in a drug for inhibiting the proliferation of mouse leukemia cells L1210 cells. Background technique [0002] The standard number of Qingmei Ganmao Granules is WS-11318 (ZD-1318)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made from 200g of Artemisia annua, 267g of Five Fingers Mandarin, 134g of Carrot, 200g of Dog Liver, 134g of Licorice, 134g of Centella asiatica, and 267g of Gangmei, which has cooling and antipyretic effects. For Fengreganmao, headache, cough, stuffy nose. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingmei Ganmao Granules. However, the method of extracting volatile oil and decocting ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K36/85A61K9/20A61P35/02
Inventor 孙波
Owner 侯玲
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