Pharmaceutical composition for treating rhinitis

A composition and drug technology, applied in the field of medicine, can solve problems such as ineffective treatment and capillary atrophy, and achieve the effect of facilitating drug absorption

Active Publication Date: 2014-04-30
SHANDONG TIANSHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitations of the excipients used in nasal drops, its therapeutic effect is not obvious, and it also causes serious side effects such as capillary atrophy inside the nasal cavity

Method used

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  • Pharmaceutical composition for treating rhinitis
  • Pharmaceutical composition for treating rhinitis
  • Pharmaceutical composition for treating rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Naphthalene Naphthalene Nasal Spray

[0024] Prescription: 1000 sticks

[0025]

[0026] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate in an appropriate amount of container, add purified water, and place at room temperature Stir under low pressure, after the above materials are dissolved, add purified water to the full amount, filter through a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution with a pH value of 6.4, and distribute it in a qualified container under the condition of avoiding bacteria. In a spray bottle, inspected, packaged.

[0027]

Embodiment 2

[0028] Embodiment 2 Naphthalene Naphthalene Nasal Spray

[0029] Prescription: 1000 sticks

[0030] sodium cromolyn 150.0g Naphazoline Hydrochloride 5g Chlorpheniramine maleate 30g Polyethylene glycol (PEG) lauryl hydroxystearate 100g purified water Add to 10000ml

[0031] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate in an appropriate amount of container, add purified water, and place at room temperature Stir under low pressure, after the above materials are dissolved, finally add purified water to the full amount, filter through a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution with a pH value of 5.7, and pack it in a qualified container under the condition of avoiding bacteria. spray bottle, inspection, packaging.

[0032]

Embodiment 3

[0033] Example 3 Naphthalene Naphthalene Nasal Spray

[0034] Prescription: 1000 sticks

[0035] sodium cromolyn 100.0g Naphazoline Hydrochloride 2.5g Chlorpheniramine maleate 25.0g Polyethylene glycol (PEG) lauryl hydroxystearate 55g purified water Add to 10000ml

[0036] Preparation process: Take the prescribed amount of sodium cromoglycate, naphazoline hydrochloride, chlorpheniramine maleate, polyethylene glycol (PEG) lauryl hydroxystearate in an appropriate amount of container, add purified water, and place at room temperature Stir under low pressure, after the above-mentioned materials are dissolved, add purified water to the full amount, filter with a 0.22 μm microporous membrane to obtain a chromagannaphthylamine solution with a pH value of 5.6, and distribute it in a qualified container under the condition of avoiding bacteria. In a spray bottle, inspected, packaged.

[0037]

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating rhinitis. The pharmaceutical composition contains sodium cromoglycate, naphazoline hydrochloride and chlorpheniramine maleate. The composite is a spraying agent, active ingredients in the preparation can realize fast onset of action by rapid absorption through nasal mucosa, and the composition has the advantages of high bioavailability, good compliance, convenience in carrying and use and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating rhinitis, which belongs to the field of medicine. Background technique [0002] Rhinitis is a common and frequently-occurring disease in the current market, among which allergic rhinitis is more common. Allergic rhinitis, also known as allergic rhinitis, is a local symptom of systemic allergic reaction occurring in the nasal mucosa. factors. Because the time of exposure to allergens and the patient's body reaction are different, it is clinically divided into perennial allergic rhinitis and seasonal allergic rhinitis. The former can occur at any time; the latter occurs in allergen seasons, such as spring and autumn when there is pollen. When the disease breaks out, symptoms such as nasal congestion, runny nose, hyposmia, and slurred speech often occur. These symptoms often affect normal rest and sleep, and hinder people's health and normal work. When infants and young children have bl...

Claims

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Application Information

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IPC IPC(8): A61K31/4402A61P11/02A61P37/08A61K31/352A61K31/4174
Inventor 秦庆福李本超徐宜铁梁霞马志国
Owner SHANDONG TIANSHUN PHARMA
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