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Superparamagnetic nanosphere and preparation method thereof

A superparamagnetic and nanosphere technology, applied in the field of nanomaterials, can solve the problems of low particle loading density, uneven particle distribution, uneven particle size, etc., and achieve the effect of improving stability, overcoming uneven distribution, and improving loading density.

Active Publication Date: 2017-10-13
SHENZHEN INST OF ADVANCED TECH
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  • Abstract
  • Description
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Problems solved by technology

[0006] The purpose of the present invention is to provide a superparamagnetic nanosphere with excellent superparamagnetic properties, uniform particle size, rapid magnetic separation, and stable dispersion in water and its preparation method, aiming at solving the problem of existing SiO 2 / Fe 3 o 4 The active ingredient of nanocomposite Fe 3 o 4 Particle distribution is uneven, and Fe 3 o 4 The disadvantage of low particle loading density avoids the disadvantages of non-uniform particle size and low crystallinity of the aqueous phase synthesis method in the existing preparation method, and simplifies the complex process of particle surface modification, assembly and phase transfer

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  • Superparamagnetic nanosphere and preparation method thereof

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preparation example Construction

[0024] Correspondingly, the embodiment of the present invention also provides a preparation method of the above-mentioned superparamagnetic nanospheres, the process flow of the preparation method is as follows figure 1 shown. The preparation method of the superparamagnetic nanosphere comprises the following steps:

[0025] S01. Obtain the above SiO 2 nanoparticles;

[0026] S02. On SiO 2 In situ growth of Fe on the outer surface of nanoparticles 3 o 4 Nanoparticles: the SiO in step S01 2 The nanoparticles are miscible with the polyol solution, then the organic iron compound is added, and heated to reflux to obtain the above SiO 2 In situ growth of nanoparticles as templates to form Fe 3 o 4 Shell SiO 2 @Fe 3 o 4 nanospheres;

[0027] S03. In Fe 3 o 4 The outer surface of the layer is coated with SiO 2 Shell: SiO2 in step S02 2 @Fe 3 o 4 The composite nanospheres are dispersed in a surfactant-solution, and tetraethyl orthosilicate is added under alkaline condi...

Embodiment 1

[0042] A superparamagnetic nanosphere and a preparation method thereof. The preparation method of this superparamagnetic nanosphere is as follows

[0043] S11. Obtain SiO 2 Nanoparticles: Mix 75mL of cyclohexane, 18mL of n-hexanol and 17.7mL of Triton X-100, add 4.2mL of water and 600 μL of ammonia to form an inverse microemulsion; then add 1.5mL of TEOS, and the inverse microemulsion was stirred at room temperature for 48 h; then 70 mL of ethanol was added to break the emulsion, centrifuged at 6000 rpm for 5 min, and the precipitate was washed with isopropanol, ethanol and water in sequence to obtain SiO with a diameter of 82 nm. 2 ball;

[0044] S12. In situ growth of Fe 3 o 4 Nanoparticles: 75 mg of SiO obtained in step S11 2 Dissolve the ball in 500 μL of ethanol, add it into a two-necked round-bottomed flask containing 5ml triethylene glycol and 66mg iron acetylacetonate; drain the ethanol in the solution under vacuum, raise the temperature to 110°C and keep it for 2...

Embodiment 2

[0047] A superparamagnetic nanosphere and a preparation method thereof. The preparation method of this superparamagnetic nanosphere is as follows

[0048] S21. Obtain SiO 2 Nanoparticles: Mix 75mL of cyclohexane, 18mL of n-hexanol and 17.7mL of Triton X-100, add 4.2mL of water and 600 μL of ammonia to form an inverse microemulsion; then add 1.5mL of TEOS, and the inverse microemulsion was stirred at room temperature for 48 h; then 70 mL of ethanol was added to break the emulsion, centrifuged at 6000 rpm for 5 min, and the precipitate was washed with isopropanol, ethanol and water in sequence to obtain SiO with a diameter of 82 nm. 2 ball;

[0049] S22. In situ growth of Fe 3 o 4 Nanoparticles: 375 mg of SiO obtained in step S21 2Dissolve the ball in 2.5ml of ethanol, add it into a two-necked round-bottomed flask containing 25ml of triethylene glycol and 330mg of iron acetylacetonate; drain the ethanol in the solution under vacuum, raise the temperature to 110°C and keep i...

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Abstract

The invention provides a superparamagnetic nanosphere and a preparation method thereof, comprising SiO2 nanoparticles, a Fe3O4 layer and a SiO2 layer, the Fe3O4 layer uses SiO2 nanoparticles as a template to form a shell layer by in-situ growth of Fe3O4 nanoparticles, and the SiO2 layer is deposited on the outer surface of the Fe3O4 layer to form a cladding layer. The superparamagnetic nanospheres use colloidal SiO2 nanoparticles as templates, so that the size of SiO2@Fe3O4@SiO2 nanospheres can be adjusted by changing the size of template SiO2 nanoparticles; by in-situ growth on the surface of template SiO2 nanoparticles Coating Fe3O4 nanoparticles by means of a method greatly increases their loading density and simplifies the synthesis conditions. At the same time, the stability of Fe3O4@SiO2 nanospheres can be significantly improved by coating the outer surface of Fe3O4 layer with SiO2.

Description

technical field [0001] The invention belongs to the field of nanomaterials, in particular to a superparamagnetic nanosphere and a preparation method thereof. Background technique [0002] Magnetic separation technology is a new type of separation technology for the comprehensive separation of biomolecules and cells based on solid phase carriers. The principle is to use the specific interaction between the ligand (or receptor) on the surface of the functionalized magnetic particles and the receptor (or ligand), such as: antibody-antigen interaction or avidin-biotin and other systems to achieve Rapid separation of targeted biological target molecules. Based on the principle of hydrodynamics, the magnetic particles can quickly contact the target biomolecules to be separated so that the target molecules to be separated are bound to the surface of the magnetic particles. Then, under the action of an external magnetic field, the target biomolecules or cells are rapidly enriched ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/11B01J13/02A61K49/08A61K47/04C12N5/00C07K1/14
Inventor 粟武黄亮敖丽娇
Owner SHENZHEN INST OF ADVANCED TECH
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