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Method for producing carrier-free highly pure 177lu compounds and carrier-free 177lu compounds

A compound and high-purity technology, applied in chemical instruments and methods, separation methods, solid adsorbent liquid separation, etc., can solve the problems of adverse effects on the quality of radiopharmaceuticals, adverse effects on the production of radiopharmaceuticals, failure to achieve high specific radioactivity and purity, etc. , to achieve the effect of improving the quality

Active Publication Date: 2014-04-09
아이티엠이소토페테크놀로지스뮌헨에스이
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Failure to achieve high specific activity and purity can lead to, among other problems, adverse effects on the production of the radiopharmaceutical or on the quality of the radiopharmaceutical itself

Method used

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  • Method for producing carrier-free highly pure 177lu compounds and carrier-free 177lu compounds
  • Method for producing carrier-free highly pure 177lu compounds and carrier-free 177lu compounds
  • Method for producing carrier-free highly pure 177lu compounds and carrier-free 177lu compounds

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Embodiment

[0086] The present invention is where radiation from a reactor 176 Extract from Yb 177 Method of manufacture of Lu n.c.a. For this purpose, the irradiated ampoules are opened in the ampoule cup and transferred into the transformation vessel (F1). 176 Yb may exist as an insoluble oxide. for extraction during irradiation 177 Lu, the substrate must be converted to a soluble form. In this example, this can be achieved by using 1M to 12M HNO 3 To achieve, can be heated when needed.

[0087] By adding HNO 3 Diluted to lower acid concentrations between 0.01M and 1.5M, the solution can be loaded onto the pre-column system (VS1) as the first column. By loading, the column material in the pre-column system, the polystyrene-based macroporous cation exchanger, is converted into negative H for separation. + form (protonated form). By using NH 4 Cl, the column material of the pre-column system is converted to its NH 4 + form. Subsequently, the precolumn system VS1 was washed wi...

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Abstract

The present invention relates to a column chromatography method for producing carrier-free, highly pure 177Lu compounds for medical purposes. In the method according to the invention, a cation exchanger and a suitable complexing agent are used. The method according to the invention for the first time permits for carrier-free, highly pure 177Lu compounds to be made available in highly pure form in milligram amounts for pharmaceutical-medical purposes from 176Yb compounds which are irradiated with thermal neutrons, wherein the radionuclides 177Lu and 176Yb are present for the purification in a mass ratio of approximately 1:102 to 1:1010.

Description

technical field [0001] The present invention relates to the manufacture of substantially carrier-free high-purity 177 The method of Lu compound, and according to claim 12 added without carrier 177 Lu compounds. Background technique [0002] Due to the promising prospects of basic clinical methods of radionuclide therapy and radionuclide 177 Lu's demand is increasing. As having a short half-life T 1 / 2 = 6.71 days for low energy beta emitters, 177 Lu constitutes an excellent carrier for the specific deposition of large amounts of energy in a small volume. These physical properties are largely used in the form of radioimmuno-radionuclide therapy and peptide receptor radionuclide therapy in oncology, especially for the treatment and diagnosis of tumors. [0003] As we all know, 177 Lu can be produced via the following nuclear reactions: [0004] Direct method: 176 Lu(n,y) 177 Lu (1) [0005] Indirect method: 176 Yb(n,y) 177 Yb → 177 Lu (2) [0006] The nuclear rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G21G1/00A61K33/244
CPCB01D15/1871G21G2001/0094G21G1/001A61K33/24B01D15/362B01D15/166C22B59/00A61P35/00A61K33/244
Inventor 塞巴斯蒂安·马克斯马克·哈尔芬施特勒康斯坦丁·哲诺斯科夫托墨·尼古拉
Owner 아이티엠이소토페테크놀로지스뮌헨에스이
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