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Pharmaceutical composition containing 17 amino acids

A composition and amino acid technology, which can be used in drug combinations, metabolic diseases, etc., can solve the problems of increased cost, high price, and reduced stability of liquid medicine, and achieve the effects of reduced cost, low production cost, and reduced material consumption.

Active Publication Date: 2013-03-13
湖北长联杜勒制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing 17 kinds of amino acid compositions contain hydrochloride, and a large amount of sodium hydroxide or other pH value regulators need to be added during preparation. The addition of these auxiliary materials also brings some inorganic metal ions, and the oxidation reaction of inorganic metal ions on amino acids Acts as Cuihua, reducing the stability of the liquid medicine during production and storage
At the same time, the high price of amino acid hydrochloride itself and the addition of pH regulators lead to unnecessary cost increases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1) Weigh the following raw and auxiliary materials in the composition:

[0046] Proline 2.9Kg, Serine 2.9 Kg,

[0047] Alanine 5.33 Kg, Isoleucine 0.87 Kg,

[0048] Leucine 1.18 Kg, Tyrosine 0.165 Kg,

[0049] Glutamic acid 2.28 Kg, phenylalanine 1.03 Kg,

[0050] Arginine 2.89 Kg, Lysine Acetate 1.96 Kg,

[0051] Valine 0.95 Kg, Threonine 1.12 Kg,

[0052] Histidine 0.725 Kg, Tryptophan 0.43 Kg,

[0053] Methionine 1.12 Kg, Acetylcysteine ​​0.22 Kg,

[0054] Glycine 3.23 Kg, Sorbitol 50 Kg,

[0055] Sodium bisulfite 0.5 Kg, add water for injection to full volume: 1000L.

[0056] 2) Add about 600L water for injection into the concentrated tank, fill it with nitrogen for more than 15 minutes, heat it up to 95°C while filling nitrogen, and add tyrosine, isoleucine, Valine, leucine, and methionine were stirred and boiled for 30 minutes until they were all dissolved to obtain a solution, and the whole process was protected by nitrogen.

[0057] 3) Under the protect...

Embodiment 2

[0063] 1) Weigh the following raw and auxiliary materials in the composition:

[0064] Proline 4.83 Kg Serine 4.83 Kg

[0065] Alanine 8.88 Kg Isoleucine 1.45 Kg

[0066] Leucine 1.97 Kg Tyrosine 0.28 Kg

[0067] Glutamic acid 3.80 Kg Phenylalanine 1.72 Kg

[0068] Arginine 4.82 Kg Lysine Acetate 3.27 Kg

[0069] Valine 1.58 Kg Threonine 1.87 Kg

[0070] Histidine 1.21 Kg Tryptophan 0.72 Kg

[0071] Methionine 1.87 Kg Acetylcysteine ​​0.37 Kg

[0072] Glycine 5.38 Kg Sorbitol 50 Kg

[0073] Sodium bisulfite 0.5 Kg Add water for injection to the full amount: 1000L.

[0074] 2) Add about 600L water for injection into the concentrated tank, fill it with nitrogen for more than 15 minutes, heat it up to 95°C while filling nitrogen, and add tyrosine, isoleucine, Valine, leucine, and methionine were stirred and boiled for 30 minutes until they were all dissolved to obtain a solution, and the whole process was protected by nitrogen.

[0075] 3) Under the protection of nitrog...

Embodiment 3

[0081] 1) Weigh the following raw and auxiliary materials in the composition:

[0082] Proline 4.5 Kg Serine 4.5 Kg

[0083] Alanine 7 Kg Isoleucine 1.1 Kg

[0084] Leucine 1.5 Kg Tyrosine 0.2 Kg

[0085] Glutamic acid 3.2 Kg Phenylalanine 1.3 Kg

[0086] Arginine 3.2 Kg Lysine Acetate 3.0 Kg

[0087] Valine 1.0 Kg Threonine 1.65Kg

[0088] Histidine 1.0 Kg Tryptophan 0.5 Kg

[0089] Methionine 1.5 Kg Acetylcysteine ​​0.3 Kg

[0090] Glycine 4.0 Kg Sorbitol 50 Kg

[0091] Sodium bisulfite 0.5 Kg Add water for injection to the full amount: 1000L.

[0092] 2) Add about 600L water for injection into the concentrated tank, fill it with nitrogen for more than 15 minutes, heat it up to 95°C while filling nitrogen, and add tyrosine, isoleucine, Valine, leucine, and methionine were stirred and boiled for 30 minutes until they were all dissolved to obtain a solution, and the whole process was protected by nitrogen.

[0093] 3) Under the protection of nitrogen, cool the soluti...

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Abstract

The invention relates to a pharmaceutical composition containing 17 amino acids. The pharmaceutical composition comprises the following raw materials and auxiliary materials: proline, serine, alanine, isoleucine, leucine, tyrosine, glutamic acid, phenylalanine, arginine, lysine acetate, valine, threonine, histidine, tryptophan, methionine, acetylcysteine, glycine, sorbitol, and sodium bisulfite. The product is free of chlorine ion, and is wider in application crowd range; in the production, an acid or a base is not additionally added for adjusting the pH value; and the product is prepared according to the component ratio, and has the pH value of 5.5-7.0. Therefore, the pharmaceutical composition meets the pharmaceutical registering requirements that the material consumption is reduced and the production cost is lower, and has equivalent or better quality and stability as compared with the commercially available products.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing 17 kinds of amino acids. Background technique [0002] The existing 17 kinds of amino acid compositions contain hydrochloride, and a large amount of sodium hydroxide or other pH value regulators need to be added during preparation. The addition of these auxiliary materials also brings some inorganic metal ions, and the oxidation reaction of inorganic metal ions on amino acids It plays the role of Cuihua, which reduces the stability of the liquid medicine in the process of production and storage. At the same time, factors such as the high price of amino acid hydrochloride itself and the addition of pH regulators lead to unnecessary cost increases. Contents of the invention [0003] In order to solve the above technical problems, the present invention provides a pharmaceutical composition containing 17 kinds of amino acids, canceling the arginine hydrochloride and histidine hydrochloride...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4172A61P3/02A61K31/198A61K31/401A61K31/405
Inventor 刘先言阙宗彬刘义
Owner 湖北长联杜勒制药有限公司
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