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Block polymer with pH/temperature/light triple responsiveness and preparation method thereof

A block polymer, responsive technology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of cumbersome preparation methods of PAMAM, and achieve the effect of simplifying the synthesis process and steps, mild conditions and simple steps

Active Publication Date: 2014-04-09
SKSHU PAINT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of PAMAM is cumbersome

Method used

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  • Block polymer with pH/temperature/light triple responsiveness and preparation method thereof
  • Block polymer with pH/temperature/light triple responsiveness and preparation method thereof
  • Block polymer with pH/temperature/light triple responsiveness and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 A kind of preparation method of pH / temperature / fluorescent triple corresponding block polymer, comprises the following steps:

[0036] (1) Preparation of active monomer p-nitrophenoxycarboxyethyl methacrylate (NPCEMA):

[0037] Add 100mmol HEMA, 120mmol pyridine and 100mL dichloromethane into a 2-necked flask, and lower the temperature with an ice-water bath. Dissolve 120mmol of p-nitrophenyl chloroformate in 40mL of dichloromethane, and add it dropwise into the flask, and gradually rise to room temperature for reaction. Washed three times with dilute hydrochloric acid and saturated brine respectively, and anhydrous Na 2 SO 4 After drying, filtering, concentration, and passing through a basic alumina column, the obtained crude product was recrystallized in n-hexane, and then precipitated in cold methanol, and the precipitate was dried in a vacuum oven to obtain the white powder product NPCEMA.

[0038] (2) Preparation of poly-p-nitrophenoxycarbonoxyethyl...

Embodiment 2

[0044] Embodiment 2 A preparation method of a pH / temperature / fluorescent triple corresponding block polymer, comprising the following steps:

[0045] (1) Preparation of active monomer p-nitrophenoxycarboxyethyl methacrylate (NPCEMA):

[0046] Add 80mmol HEMA, 100mmol pyridine and 150mL N,N-dimethylformamide into a two-necked flask, and lower the temperature with an ice-water bath. Dissolve 100mmol of p-nitrophenyl chloroformate in 30mL of N,N-dimethylformamide, and slowly add it dropwise into the flask, and gradually rise to room temperature for reaction. Washed three times with dilute hydrochloric acid, saturated brine, anhydrous Na 2 SO 4 After drying, filtering, concentration, and passing through a basic alumina column, the obtained crude product was recrystallized in n-hexane, and then precipitated in cold methanol. After filtering, the product was dried in a vacuum oven to obtain a white powder product NPCEMA.

[0047] (2) Preparation of poly-p-nitrophenoxycarbonoxyeth...

Embodiment 3

[0053] Embodiment 3 A preparation method of a pH / temperature / fluorescent triple corresponding block polymer, comprising the following steps:

[0054] (1) Preparation of active monomer p-nitrophenoxycarboxyethyl methacrylate (NPCEMA):

[0055] Add 150mmol HEMA, 120mmol pyridine and 100mL dichloromethane into a two-necked flask, and lower the temperature with an ice-water bath. Dissolve 150mmol of p-nitrophenyl chloroformate in 50mL of dichloromethane, and slowly drop it into the flask, and gradually rise to room temperature for reaction. Washed three times with dilute hydrochloric acid, saturated brine, anhydrous Na 2 SO 4 After drying, filtering, concentration, and passing through a basic alumina column, the obtained crude product was recrystallized in n-hexane, and then precipitated in cold methanol. After filtering, the product was dried in a vacuum oven to obtain a white powder product NPCEMA.

[0056] (2) Preparation of poly-p-nitrophenoxycarbonoxyethyl methacrylate mac...

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Abstract

The invention relates to a block polymer with pH / temperature / light triple responsiveness and a preparation method thereof. The block polymer is prepared by applying RAFT (Reversible Addition Fragmentation chain Transfer) polymerization, and a product can be obtained after being treated by ethidene diamine and being purified. The preparation method disclosed by the invention is simple to operate and controllable in process; the prepared block polymer with triple responsiveness has wide application prospect in fields such as functional paint, drug controlled release and bio-imaging.

Description

technical field [0001] The invention relates to the field of polymer chemical synthesis, in particular to a block polymer with pH / temperature / light triple responsiveness and a preparation method thereof. technical background [0002] At present, in the research on temperature-responsive polymers, poly-N-isopropylacrylamide (PNIPAAm) is the most researched. When the ambient temperature is lower than its LCST, PNIPAAm exhibits random stretching in aqueous solution and is water-soluble. ; And when the temperature is above LCST, PNIPAAm shrinks and forms micelles. In recent years, with the continuous deepening of research work, people have combined the temperature sensitivity of PNIPAAm polymers with other environmental responses to obtain block polymers with multiple responsiveness. For example, the papers such as Li YY Biomacromolecules, 2006, 7 (11): 2956-2960; the papers such as Suchaoin N, Polymer, 2009, 50 (17): 4151-4158; Chinese patent CN101838375A and Chinese patent CN...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08F220/36C08F220/54C08F8/32C09K11/06
Inventor 洪杰魏川吴金梅叶映林
Owner SKSHU PAINT
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