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Method for preparing chitosan-based silver-loaded composite antimicrobial superfine fiber membrane

A composite antibacterial and microfiber technology, applied in the field of medical materials, can solve the problems of easy sealing of silver, large silver-loaded particle size, and weak adsorption capacity of silver-containing dressings, etc. The effect of drug resistance

Inactive Publication Date: 2014-04-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the electrospinning film forming technology, the chelating, reducing and stabilizing effects of chitosan on silver ions are used to solve the problems of large particle size, uneven distribution and unstable antibacterial effect of silver-loaded particles in the prior art; The fiber has the characteristics of large specific surface area and high porosity, which solves the problem of weak adsorption capacity of silver-containing dressings and easy sealing of silver; at the same time, the small pore size between microfiber membrane fibers can prevent the erosion of external bacteria to a certain extent, and achieve silver Gradual sustained release effect of

Method used

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  • Method for preparing chitosan-based silver-loaded composite antimicrobial superfine fiber membrane
  • Method for preparing chitosan-based silver-loaded composite antimicrobial superfine fiber membrane
  • Method for preparing chitosan-based silver-loaded composite antimicrobial superfine fiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Measure glacial acetic acid and distilled water to prepare an aqueous solution of acetic acid with a mass fraction of 90%, measure 9.6 g of an aqueous solution of acetic acid with a mass fraction of 90%, add 470 μL of 0.1 mol / L silver nitrate solution to it, stir to dissolve it, and weigh Dissolve 0.1g of PEO and 0.3g of CS powder in the above solution, place it on a magnetic stirrer and keep stirring continuously for 10 hours in the dark, and let it stand for one hour to defoam to obtain a uniform and transparent viscous spinning solution.

[0031] The above spinning solution was added to the electrospinning device, and the electrospinning was carried out under the conditions of voltage 10kv, injection speed 0.24mL / h, receiving distance 25cm, ambient temperature 20°C, and relative humidity 30%.

[0032] The obtained white nanofiber membrane was vacuum-dried for 24 hours to remove the residual solvent to obtain a chitosan-based silver-loaded composite antibacterial micro...

Embodiment 2

[0034] Measure 9.6 g of acetic acid aqueous solution with a mass fraction of 90%, add 940 μL of 0.1 mol / L silver nitrate solution to it, stir evenly, weigh 0.04 g of PEO and 0.36 g of CS powder and dissolve them in the above solution, place them on a magnetic stirrer to avoid Stir continuously for 10 hours, let it stand for one hour to defoam, and obtain a uniform and transparent viscous spinning solution.

[0035] The above spinning solution was added to the electrospinning device, and the electrospinning was carried out under the conditions of voltage 12kv, injection speed 0.5mL / h, receiving distance 20cm, ambient temperature 20°C, and relative humidity 40%.

[0036] The obtained white nanofiber membrane was vacuum-dried for 24 hours to remove the residual solvent to obtain a chitosan-based silver-loaded composite antibacterial microfiber membrane, which was stored in a desiccator away from light. Such as figure 2 As shown, the fiber diameter of the obtained chitosan-based...

Embodiment 3

[0038] Measure 9.6 g of acetic acid aqueous solution with a mass fraction of 90%, add 940 μL of 0.1 mol / L silver nitrate solution to it, stir evenly, weigh 0.1 g of PEO and 0.3 g of CS powder and dissolve in the above solution, place on a magnetic stirrer to avoid Stir continuously under light for 10 h, place the solution under ultraviolet light for 20 min, and then place it on a magnetic stirrer to stir for 1.5 h to obtain a brown viscous spinning solution.

[0039] The above spinning solution was added to the electrospinning device, and the electrospinning was carried out under the conditions of voltage 15kv, injection speed 0.5mL / h, receiving distance 30cm, ambient temperature 20°C, and relative humidity 40%.

[0040]The obtained white nanofiber membrane was vacuum-dried for 24 hours to remove the residual solvent to obtain a chitosan-based silver-loaded composite antibacterial microfiber membrane, which was stored in a desiccator away from light. Such as image 3 As shown...

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Abstract

The invention provides a method for preparing a chitosan-based silver-loaded composite antimicrobial superfine fiber membrane. The method is characterized by particularly comprising the following steps: 1, adding silver nitrate powder into an acetic acid aqueous solution with the mass fraction of 50-90%, stirring to dissolve to obtain a solution, weighing and adding chitosan and polyoxyethylene or polyvinyl alcohol powder into the solution, and stirring to obtain a spinning solution; and 2, adding the spinning solution into an electrostatic spinning device, carrying out electrostatic spinning under the conditions that the voltage is 10-20kv, the spinning solution injecting speed is 0.1-1.0mL / h, the receive distance is 8-30cm, the spinning temperature is 20-50 DEG C and the relative humidity is 10-55%, carrying out vacuum drying on the obtained white nanofiber membrane for 12-36 hours, and removing the residual solvent to obtain the chitosan-based silver-loaded composite antimicrobial superfine fiber membrane. The electrospun fiber membrane has the advantages of a certain mechanical property, good antimicrobial property and water absorbing ability and can be used for the fields of wound surface nursing and medical dressings with different anti-infection requirements through designing the compositing ratio of the chitosan and the nanometer silver.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an antibacterial microfiber film for medical dressings and a preparation method thereof. Background technique [0002] Studies have shown that wound infection is one of the most common complications in the field of burn care, which can lead to delayed wound healing, increase nursing costs and patient suffering, and may even lead to death of burn patients. Therefore, it is of great clinical significance to develop high-efficiency antibacterial medical dressings. [0003] At present, traditional medical dressings have single performance and cannot meet the requirements of antibacterial, moisturizing, wound protection and healing promotion; hydrogel, hydrocolloid or sponge dressings in new dressings can create a moist microenvironment for the wound, but they do not contain antibacterial ingredients, unable to resist the invasion of external microorganisms into the wound. ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44D04H1/4382D04H1/728
Inventor 高晶王晓丽王璐程凤孙立军徐海燕
Owner DONGHUA UNIV
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