Chinese medicinal composition for preventing radioactive oral mucosa reaction

An oral mucosa and composition technology, which is applied in the field of traditional Chinese medicine compositions for preventing radioactive oral mucosal reactions, can solve the problems of affecting curative effect, increased radiotherapy toxicity, increased radiotherapy mucosal damage, etc., and achieves the effects of good curative effect and no toxic and side effects.

Active Publication Date: 2014-04-09
华宇中研药业(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the curative effect of concurrent chemotherapy and radiotherapy is certain, the correlation and the increase of radiotherapy toxicity are also certain. Due to the increase of acute toxicity, the unplanned interruption of radiotherapy often affects the curative effect. At the same time, the additive effect of drug toxicity also affects the quality of life of patients, especially Although precise radiotherapy can reduce the damage of high-risk organs at present, the mucosal damage of radiotherapy increases due to the dose relationship, especially the operability of simultaneous radiochemical treatment for stage III / IV nasopharyngeal carcinoma is affected by the addition of chemotherapy.

Method used

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  • Chinese medicinal composition for preventing radioactive oral mucosa reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 oral liquid 1

[0086] 35g Shegan, 60g Coptidis Rhizoma, 30g Houttuynia cordata, 35g Zhimu, 30g Zhuru, 40g Agrimony, 40g Chrysanthemum, 30g Wintersweet, 30g Mulan, 35g Oxtail, 30g Goosegrass, 35g Baijiu, Yuanbao Grass 20g, Cat's Claw 30g, Bellflower 20g, Pueraria 25g, Bupleurum 25g, Scrophulariaceae 30g and Mingdangshen 35g were crushed respectively, mixed to obtain a mixture, added 4kg of water, soaked for 5 hours and then distilled for 5 hours to collect volatile oil. The slag is set aside, 60g of Acanthopanax, 75g of Codonopsis, 50g of Ligustrum lucidum, 30g of coix seed, 35g of dendrobium, 35g of madder, 25g of angelica, 35g of red peony, 30g of curcuma, 35g of selaginella, 40g of heterophylla, 35g of uncaria, and Chinese yam 25g, 25g of rhubarb, 25g of jujube and 35g of dodder were crushed respectively, put into the continuous extraction tank, then added the medicinal residues obtained above, added 4kg of water to extract for 5 hours, filtered the extr...

Embodiment 2

[0087] Embodiment 2 oral liquid 2

[0088]Shegan 40g, Coptidis 65g, Houttuynia cordata 35g, Anemarrhena 40g, Zhuru 35g, Agrimony 45g, Chrysanthemum 40g, Wintersweet 30g, Mulan 30g, Oxtail 35g, Goosegrass 30g, Liquor grass 35g, Yuanbao 20g grass, 25g cat's claw, 15g bellflower, 20g kudzu root, 20g bupleurum, 25g scrophulariaceae and 30g Mingdangshen were crushed and mixed to obtain a mixture, added 4.2kg of water, soaked for 5 hours and then distilled for 5 hours to collect volatile oil. The dregs of the medicine are set aside, 65g of Acanthopanax, 80g of Codonopsis, 55g of Ligustrum lucidum, 35g of coix seed, 40g of dendrobium, 40g of madder, 25g of angelica, 35g of red peony, 30g of curcuma, 35g of selaginella, 40g of heterophylla, 35g of uncaria, 25g of Chinese yam, 25g of rhubarb rhubarb, 25g of jujube and 35g of dodder were pulverized respectively, put into the continuous extraction tank, then added the dregs obtained above, added 4kg of water to extract for 5 hours, filte...

Embodiment 3

[0089] Embodiment 3 oral liquid 3

[0090] Will shoot 35g, Coptidis 60g, Houttuynia cordata 30g, Anemarrhena 35g, Zhuru 30g, Agrimony 40g, Chrysanthemum 35g, Wintersweet 25g, Mulan 25g, Oxtail 30g, Goosegrass 25g, Liquor grass 30g, 15g Yuanbaocao, 30g Cat's Claw, 20g Campanulaceae, 25g Pueraria Radix, 25g Bupleurum, 30g Scrophulariaceae and 35g Mingdangshen were crushed and mixed to obtain the mixture, added 4kg of water, soaked for 5 hours and then distilled for 5 hours to collect the volatile oil. The dregs of the medicine are set aside, 60g of Acanthopanax, 75g of Codonopsis, 50g of Ligustrum lucidum, 30g of coix seed, 35g of dendrobium, 35g of madder, 20g of angelica, 30g of red peony, 25g of curcuma, 30g of Selaginella, 35g of heterophylla, 30g of uncaria, 20g of Chinese yam, 20g of rhubarb rhizome, 20g of jujube and 30g of dodder were pulverized respectively, put into the continuous extraction tank, then added the medicinal residues obtained above, added 4kg of water to ...

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Abstract

The invention provides a Chinese medicinal composition for preventing a radioactive oral mucosa reaction. The Chinese medicinal composition comprises the raw materials including acanthopanax root, radix codonopsis, fructus ligustri lucidi, rhizoma belamcandae, semen coicis, herba dendrobii, coptis root, herba houttuyniae, rhizoma anemarrhenae, madder, caulis bambusae in taenian, herba agrimoniae, angelica, radix paeoniae rubra, chrysanthemum, zedoary, herba selaginellae, heterophylly falsestarwort root, uncaria, yam, chimonanthus nitens, indigofera tinctoria, meadow fescue, eleusine indica, conyza japonica, hypericum sampsonii hance, franzenbach rhubarb root and rhizome, jujube, semen cuscutae, buttercup root, balloonflower root, kudzu root, radix bupleuri, figwort and radix changii. The Chinese medicinal composition has a good treatment effect, does not have toxic or side effect, can be used as an auxiliary treatment medicament for radiotherapy and chemotherapy of nasopharyngeal cancer, can be quite beneficial to enhancing the curative effect of radiotherapy and chemotherapy, relieving the radioactive oral mucosa reaction after radiotherapy and improving the quality of life when being simultaneously used in radiotherapy and chemotherapy of a nasopharyngeal cancer patient, and also shows a good prospect for combined treatment of malignant tumors at the same time.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing radioactive oral mucosal reaction. Background technique [0002] Nasopharyngeal carcinoma is a high incidence of head and neck tumors in southern my country and Asian Chinese. The etiology is related to factors such as Epstein-Barr virus infection, genetics, and environmental pollution. Radiation therapy is currently the first choice for effective treatment. The 5-10-year survival rate of nasopharyngeal carcinoma patients treated with single radiotherapy is only about 40%. The treatment of stage III / IV nasopharyngeal carcinoma has become a standard method to improve the curative effect. At present, platinum-based drug combination therapy is mostly used. The combination of radiotherapy and chemotherapy can improve the survival rate, reduce local recurrence and reduce the incidence of distant metastasis....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61P1/02
Inventor 陈朝晖闫莉
Owner 华宇中研药业(北京)有限公司
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