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A kind of carbon phosphorus chiral dihydrocarbyl phosphine oxide and its synthesis method

A synthesis method and technology of charged phenyl phosphine oxide are applied in the synthesis field of carbon phosphorus chiral dihydrocarbyl phosphine oxide, and can solve the problem of low stereoselectivity of chiral phosphorus atom reaction, difficult compound acquisition, and tedious and tedious resolution process. And other issues

Inactive Publication Date: 2015-11-25
LIAOCHENG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the difficulty in obtaining phosphorus-chiral compounds, cumbersome and lengthy resolution processes are often required, and the stereoselectivity of the reaction to form chiral phosphorus atoms is not high, the research and application of corresponding phosphorus-chiral phosphine ligands have been restricted

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  • A kind of carbon phosphorus chiral dihydrocarbyl phosphine oxide and its synthesis method
  • A kind of carbon phosphorus chiral dihydrocarbyl phosphine oxide and its synthesis method
  • A kind of carbon phosphorus chiral dihydrocarbyl phosphine oxide and its synthesis method

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preparation example Construction

[0030] The present invention provides ( R P )-the synthetic method of menthyl phenyl phosphine oxide, its generalized steps are as follows:

[0031]

[0032] (1) Preparation of menthyl magnesium halide or menthyl lithium. According to the conventional preparation method, use ( L )-(-)-menthyl chloride or ( L )-(-)-menthyl bromide reacts with metal magnesium or metal lithium in ether solvents such as diethyl ether, tetrahydrofuran, etc. (for 0.1 molar scale reactions, use 50-300 ml of solvent) to obtain menthyl magnesium chloride or menthyl Magnesium bromide; use ( L )-(-)-menthyl chloride reacts with lithium metal in ether solvents such as diethyl ether or tetrahydrofuran, or hydrocarbon solvents such as petroleum ether, hexane, pentane or cyclohexane, etc. (0.1 molar scale reaction, Using 50-300 ml of solvent), a solution of menthyllithium was prepared.

[0033] (2) The menthyl magnesium halide reagent or lithium reagent solution prepared above is reacted with phenyl...

Embodiment 1

[0038] In a three-necked round-bottom flask equipped with a reflux condenser and a constant pressure dropping funnel, a magnetic stirrer was placed. The whole device was fully dried in advance and filled with nitrogen, and metal magnesium chips (2.4 g, 0.1 mol) and iodine ( 5 mg). Menthyl chloride (17.4 g, 0.1 mol) was added to a constant-pressure dropping funnel, and anhydrous tetrahydrofuran (200 ml) was added dropwise to the solution of menthyl chloride in tetrahydrofuran while stirring. After the reaction was initiated, the tetrahydrofuran solution of menthyl chloride was dropped in at a rate of 1 drop / second. After all of the menthyl chloride in tetrahydrofuran had been added, the reaction mixture was stirred and refluxed for 2 hours.

[0039] Freshly distilled phenylphosphine dichloride (14.1 ml, 0.1 mol) was dissolved in anhydrous tetrahydrofuran (200 ml). The solution was cooled in an ice-water bath, and the menthyl magnesium chloride solution prepared above was slowl...

Embodiment 2

[0045] In a three-necked round-bottom flask equipped with a reflux condenser and a constant pressure dropping funnel, a magnetic stirrer was placed. The whole device was fully dried in advance and filled with nitrogen, and metal magnesium chips (2.4 g, 0.1 mol) and iodine ( 5 mg), and immerse the round bottom flask in an oil bath. Menthyl bromide (21.8 g, 0.1 mol) was added to a constant-pressure dropping funnel, dissolved in anhydrous ether (200 ml), and the ether solution of menthyl bromide was added dropwise while stirring. After the reaction was initiated, the diethyl ether solution of menthyl bromide was dripped in at a rate of 1 drop / second. After all of the ethereal solution of menthyl bromide had been added, the reaction mixture was stirred and refluxed for 2 hours.

[0046] Dissolve freshly distilled phenylphosphine dichloride (14.1 ml, 0.1 mol) in anhydrous ether (100 ml), and cool the solution with an ice-water bath, then slowly add the menthyl magnesium bromide so...

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Abstract

The invention provides (RP)-menthyl phenyl oxygen phosphine and a synthesis method thereof. The synthesis method comprises the following steps of (1) preparing a menthyl magnesium halide or a menthyl lithium solution; (2) enabling the menthyl magnesium halide or the menthyl lithium solution to react with phenyl phosphine dichloride; (3) hydrolyzing the phenyl menthyl phosphine chloride; (4) performing post-treatment. According to the method, the obtained phenyl menthyl oxygen phosphine has a better asymmetric induction effect as containing a large-volume of mint group; besides, the chiral menthyl facilitates the stabilization of phosphorus atom configuration.

Description

technical field [0001] The present invention is a synthesis method of carbon-phosphorus chiral dihydrocarbyl phosphine oxide, which involves the compound itself, and the details of the reaction operation of synthesizing the compound, such as materials, feeding sequence, temperature, time, post-treatment, etc., including the purification process of the product , The type, amount, temperature, etc. of the solvent. Background technique [0002] As an excellent ligand and metal combination, trihydrocarbylphosphine is widely used in the production process of chemical industry. The chiral trihydrocarbylphosphine ligand, combined with a metal, can be used as a chiral catalyst in the field of asymmetric synthesis, and is an essential key material in the production process of many drugs, drug intermediates, and biologically active substances. At present, the chiral phosphine ligands used in industrial production are mostly carbon-skeleton chiral ligands, such as bis(diphenylphosphin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/53B01J31/24C07B53/00
Inventor 赵长秋张贺姬嗣玉
Owner LIAOCHENG UNIV
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