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Nux vomica total alkali micro-emulsion, preparation thereof and preparation methods of nux vomica total alkali micro-emulsion and preparation

A technology of total alkaloids and microemulsions of Strychnium chinensis, applied in anti-inflammatory agents, pharmaceutical formulas, emulsion delivery, etc., can solve the problems of large irritation, limited clinical application of Strychnium chinensis, and difficulty in ensuring curative effect

Active Publication Date: 2014-03-26
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these common external preparations are highly irritating and have a small amount of penetration, so it is difficult to guarantee the curative effect, which severely limits the clinical application of Nuxebra chinensis.

Method used

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  • Nux vomica total alkali micro-emulsion, preparation thereof and preparation methods of nux vomica total alkali micro-emulsion and preparation
  • Nux vomica total alkali micro-emulsion, preparation thereof and preparation methods of nux vomica total alkali micro-emulsion and preparation
  • Nux vomica total alkali micro-emulsion, preparation thereof and preparation methods of nux vomica total alkali micro-emulsion and preparation

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0130] Experimental example 1: Effect of microemulsion gel of strychnium total alkaloids on acute swelling and pain response index of paw and plantar of rats induced by complete Freund's adjuvant

[0131] 1. Experimental method

[0132] 1.1 Rat AA model induction

[0133] After inactivating BCG at 80°C for 1 hour, make 10mg.ml with high-pressure sterilized liquid paraffin -1 The emulsion was thoroughly ground and mixed to obtain Freund's complete adjuvant (FCA), and 0.1ml of FCA was injected into the endothelium of the left hind foot of each mouse to cause inflammation.

[0134] 1.2 Animal grouping and dosing regimen

[0135] Rats were randomly divided into 8 groups: normal group; AA model group; high dose of total strychnium microemulsion gel (25 mg. kg -1 ) group; the dose of total strychnium microemulsion gel (12.5 mg.kg -1 ) group; low dose of total alkaloid microemulsion gel (6.25 mg.kg -1 ) group; high dose of total alkaloid gel of strychnium (25 mg.kg -1 ) group; ...

experiment example 2

[0155] Experimental example 2: In vitro transdermal study of microemulsion gel of strychnium total alkaloids

[0156] 1. Experimental method

[0157] Six healthy SD rats were randomly divided into two groups (microemulsion gel group and ordinary gel group), with 3 rats in each group. After the rat was anesthetized, it was fixed on the rat fixed board in a supine position, the rat’s knee joint was depilated, disinfected with alcohol, and the probe catheter was carefully inserted into the joint cavity of the rat, leaving a section of the catheter in the joint cavity to protect the probe. Needle implantation. Insert the linear probe from one end of the catheter and slowly pull it out from the other end of the catheter. After the membrane of the linear probe enters the joint cavity, carefully pull the probe catheter out of the joint cavity so that the membrane of the linear probe remains in the joint cavity. Adjust the speed of the perfusion pump to perfuse the perfusate at a f...

Embodiment 1

[0165] Take 22g of polyoxyethylene castor oil EL-35, 26g of PEG400, add 2g of total alkali of strychnium, mix and stir to make it fully dissolved, then mix with 40g of ethyl oleate, stir evenly, slowly add 12g of water for injection, Stir at the same time to obtain microemulsion of total strychnium alkali.

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Abstract

The invention discloses a nux vomica total alkali micro-emulsion, a preparation method thereof, a preparation containing the nux vomica total alkali micro-emulsion and a preparation method of the preparation, and belongs to the field of medicinal preparations. The nux vomica total alkali micro-emulsion is prepared from nux vomica total alkali, oil phase, emulsifying agent, co-emulsifier and water phase. The nux vomica total alkali is preferably prepared to be external gel. The nux vomica total alkali transdermal drug delivery external preparation has special advantage to the medicine; a novel micro-emulsion medicine-delivery system is applied, so that the transdermal absorption of the medicine is increased, the clinical effect is enhanced, the toxic and side effect when the medicine is take orally and injected is avoided. The external preparation can be used for preparation of anti-inflammatory and analgesic medicine.

Description

technical field [0001] The invention relates to a strychnium total alkaloid microemulsion and a preparation method thereof, a preparation containing strychnium total alkaloid microemulsion and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] Nuxychnos is the mature seed of Strychno6 nux-vomica L or S Pierriana A.w.Hil1, which has the effects of dredging collaterals, relieving pain, dispelling stagnation and swelling, and is good at treating rheumatism and other diseases. Clinical application has nearly a thousand years of history. "Surgery Quansheng Ji" said that it "can search the rheumatism of the muscles and bones, and remove the phlegm poison that condenses outside the inner membrane of the skin." Nuxychnium total alkaloids are the effective parts extracted, separated and purified from the seeds of Nuxychnium, which have the functions of analgesia, anti-inflammation, promotion of chondrocyte proliferati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/56A61K9/00A61K9/107A61P29/00
Inventor 张保献吴珍珍
Owner BEIJING INCREASEPHARM CORP LTD
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